Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1997-05-28
2000-01-04
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
562 8, 435 721, 435 723, 435184, A61K 3166, C07F 928
Patent
active
06011021&
ABSTRACT:
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
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Jackson Paul F.
Maclin Keith M.
Slusher Barbara S.
Tays Kevin L.
Aulakh Charanjit S.
Guilford Pharmaceuticals Inc.
Juneau Todd L.
Nath Gary M.
Rotman Alan L.
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