Methods of cancer diagnosis using a chimeric toxin

Details Methods of cancer diagnosis using a chimeric toxin Methods of cancer diagnosis using a chimeric toxin

1998-03-24

2000-10-31

Huff, Sheela

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 72, 436 64, 530398, G01N 33574

Patent

active

061400661

ABSTRACT:
The present invention relates to methods for cancer diagnosis using a chimeric toxin. In particular, the invention relates to the use of a chimeric toxin composed of gonadotropin releasing hormone (GnRH) and Pseudomonas exotoxin A (PE) to detect a tumor-associated epitope expressed by human adenocarcinomas. Mutated GnRH-PE molecules that bind but do not kill tumor cells are exemplified.

REFERENCES:
Nechushtan et al J. Biol. Chem. vol. 272 p. 11597, 1997.
CA 127;16488, 1997.
CA 127:16487, 1997.
CA 126:1325, 1994.

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