Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-05
1999-12-21
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241331, 4241411, 4241431, 4241531, 4241731, A61K 39395
Patent
active
060045523
ABSTRACT:
Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
REFERENCES:
patent: 4355023 (1982-10-01), Ehrlich et al.
patent: 4689299 (1987-08-01), Insel et al.
patent: 4886796 (1989-12-01), Eichner et al.
patent: 4923872 (1990-05-01), Kostlan et al.
patent: 5068223 (1991-11-01), Lipsky et al.
patent: 5100899 (1992-03-01), Calne
patent: 5182368 (1993-01-01), Ledbetter et al.
patent: 5397703 (1995-03-01), De Boer et al.
patent: 5677165 (1997-10-01), De Boer et al.
patent: 5874082 (1999-02-01), De Boer
Buitlmann et al. J Clin Immunol 16: 83-89 (1996).
Resetkova et al. Thyroid 6: 267-273 (1996).
Biacone et al. Kidney Intl. 48: 458 468 (1995).
Larsen et al. Transplantation 61: 4-9 (1996).
Eerriste et al. PNAS 93: 2499-2504 (1996).
Armitage et al., "Molecular and Biological Characterization of a Murine Ligand for CD40", Nature, 357:80-82 (May 7, 1992).
Banchereau et al., "Growing Human B Lymphocytes in the CD40 System", Nature, 353:678-679 (Oct. 17, 1991).
Banchereau et al., "Long-Term Human B Cell Lines Dependent on Interleukin-4 and Antibody to CD40", Science, 251:70-72 (Jan. 4, 1991).
Chotia, et al., "Canonical Structures for the Hpervariable Regions of Immunoglobulins," J. Mol. Biol. 196, 901-917 (1987).
Clark and Shu, "Association Between IL-6 and CD40 Signaling IL-6 Induces Phosphorylation of CD40 Receptors", J. Immunol, 145(5):1400-1406 (Sep. 1, 1990).
Clark et al., "Activation of Human B Cells Mediated Through Two Distinct Cell Surface Differentiation Antigens, Bp35 and Bp50", Proc. Natl. Acad. Sci. USA, 83:4494-4498 (Jun. 1986).
Cosimi, et al., "Use of Monoclonal Antibodies To T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografats," N. Eng. J. Med., 305:308-313 (Aug. 6, 19881).
de Boer et al., "Generation of monoclonal antibodies to human lymphocyte cell surface antigens using insect cells expressing recombinant proteins", J. Immunol. Meth., 152:15-23 (1992).
DeFranco et al., "Separate Control of B Lymphoctye Early Activation and Proliferation in Response to Anti-IgM Antibodies", J. Immunol., 135(1):87-94 (Jul. 1985).
DiSanto et al., "Generation of Anti-human CD8.beta.-Specific Antibodies Using Transfectants Expressing Mixed CD8 Heterodimers," J. Immunol. Methods, 141:123-1312 (1991).
Freedman et al., "B7, A B Cell-Restricted Antigen that Identifies Preactivated B Cells", J. Immunol., 139(10):3260-3267 (Nov. 15, 1987).
Gascan et al., "Anti-CD40 Monoclonal Antibodies or CD4.sup.+ T Cell Clones and IL-4 Induce IgG4 and IgE Switching in Purified Human B Cells Via Different Signaling Pathways", J. Immunol., 147(1):8-13 (Jul. 1, 1991).
Gauchat et al., "Modulation of IL-4 Induced Germline .epsilon. RNA Synthesis in Human B Cells by Tumor Necrosis Factor-.alpha., Anti-CD40 Monoclonal Antibodies or Transforming Growth Factor-.beta. Correlates with Levels of IgE Production", Int. Immunol., 4(3):397-406 (1991).
Golub, Immunology A Synthesis, published by Sinauer Assoc. Inc., Sunderland, MA, pp. 19-20 (1987).
Gordon et al., "Resting B Lymphocytes Can Be Triggered Directly Through the CDw40 (BP50) Antigen", J. Immunol., 140(5):1425-1430 (Mar. 1, 1988).
Gruber et al., "Anti-CD45 Inhibition of Human B Cell Proliferation Depends on the Nature of Activation Signals and the State of B Cell Activation", J. Immunol., 142(12):4144-4152 (Jun. 15, 1989).
Harris et al., "Therapeutic antibodies--the coming of age", Tibtech, 11(2):42-44 (Feb. 1993).
Jabara et al., "CD4 and IgE: Synergism between Anti-CD40 Monoclonal Antibody and Interleukin 4 in the Induction of IgE Synthesis by Highly Purified Human B Cells", J. Exp. Med., 172:1861-1864 (Dec. 1990).
June et al., "Role of the CD28 Receptor in T-Cell Activation", Immunology Today, 11(6):211-216 (1990).
Jung and Fu, "Selective Inhibition of Growth Factor-Dependent Human B Cell Proliferation by Monoclonal Antibody ABI to an Antigen Expressed by Activated B Cells", J. Exp. Med., 160:1919-1924 (Dec. 1984).
Kabat et al., "Sequences of Proteins of Immunological Interest," "Tabulation and Analysis of Amino Acid and Nucleic Acid Sequences of Precursors, V-Regions, C-Regions, J-Chain, .beta..sub.2 -Microglobulins, Major Histocompatibility Antigens, Thy-1, Complement, C-Reactive Protein, Thymopoietin, Post-gamma Globulin, and .varies..sub.2 -Macroglobulin," sponsored through Contract N01-RR-8-2118 by components of the National Institutes of Health, Bethesda, MD 20205 (1983).
Kriegler et al., "A Novel Form of TNF/Cachectin Is a Cell Surface Cytotoxic Transmembrane Protein: Ramifications for the Complex Physiology of TNF," Cell 53:45-53 (1988).
Kwekkenboom et al., "CD40 plays an essential role in the activation of human B cells by murine EL4B5 cells", Immunology, 79:439-444 (1993).
Lane et al., "Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participated in T cell-dependent activation of B lymphocytes", Eur. J, Immunol., 22:2573-2578 (1992).
Ledman et al., "Anti-CD40 Monoclonal Antibody Blocks the Contact Dependent T Helper Signal Mediated by 5C8 Ag.", Clinical Research, 40:154A (1992).
Linsley et al., "CTLA-4 is a Second Receptor for the B Cell Activation Antigen B7", J. Exp. Med., 174:561-569 (Sep. 1991).
Muraguchi et al., "Sequential Requirements for Cell Cycle Progression of Resting Human B Cells After Activation by Anti-Ig", J. Immunol., 132(1):176-180 (1984).
Noelle and Snow, "T helper cells", Current Opinion in Immunology, 4:333-337 (1992).
Paulie et al., "The Human B Lymphocyte and Carcinoma Antigen, CDw40, Is a Phosphoprotein Involved in Growth Signal Transduction", J. Immunol., 142(2):590-595 (Jan. 15, 1989).
Ross et al., "Characterization of nerve growth factor in neural crest tumors using monoclonal antibodies", Proc. Natl. Acad. Sci. USA, 81:6681-6685 (Nov. 1984).
Rousset et al., "Cytokine-induced Proliferation and Immunoglobulin Production of Human B Lymphocytes Triggered Through Their CD40 Antigen", J. Exp. Med., 173:705-710 (Mar. 1991).
Sato et al., "Biological Effects in Vitro of Monoclonal Antibodies to Human Epidermal Growth Factor Receptors", Mol. Biol. Med., 1:511-529 (1983).
Splawski et al., "Immunoregulatory Role of CD40 in Human B Cell Differentiation", J. Immunol., 150(4):1276-1285 (Feb. 15, 1993).
Tanaka et al., "Distinct Reactivities of Four Monoclonal Antibodies with Human Interleukin 2 Receptor", Microbiol. Immunol., 29(10):959-972 (1985).
Uckun et al., "Temporal Association of CD40 Antigen Expression with Discreet Stages of Human B-Cell Ontogeny and the Efficacy of Anti-CD40 Immunotoxins Against Clonogenic B-Lineage Acute Lymphoblastic Leukemia as well as B-Lineage Non-Hodgkin's Lymphoma Cells", Blood, 76(12):2449-2456 (Dec. 15, 1990).
Valle et al., "mAb 104, A New Monoclonal Antibody, Recognizes the B7 antigen that is Expressed on Activated B Cells and HTLV-1-Transformed T Cells", Immunology, 69:531-535 (1990).
Webb, "Cell-surface Expression And Proliferation of Human CD4 Produced in Baculovirus-Infested Insect Cells", Proc. Natl. Acad. Sci. USA, 86:7731-7735 (Oct. 1989).
Wetzel et al., "Evidence for Two Distinct Activation States Available to B Lymphocytes", J. Immunol., 133(5):2327-2332 (Nov. 1984).
Yellin et al., "CD40 Molecules Induce Down-Modulation and Endocytosis of T Cell Surface T Cell-B Cell Activating Molecule/CD40-L", J. Immunol., 152:598-608 (1994).
Zhang et al., "CD40 Stimulation Provides an IFN-.gamma. Independent and IL-4-Dependent Differentiation Signal Directly to Human B Cells For IgE Production", J. Immunol., 146(6):1836-1842 (Mar. 15, 1991).
Gray et al. J Exp Med. 180 : 141-155 (1994).
Stuber et al. J Exp Med 183 : 693-698(1996).
Winter et al. Tips 14 : 139-143 (1993).
Kahan Curr. Opin. Immunol. 4: 553-560(1992).
Edgingt
Conroy Leah B
de Boer Mark
Blackburn Robert P.
Chan Christina Y.
Chiron Corporation
Gambel Phillip
Morley Kimberlin L.
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