Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-07
1997-10-21
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241431, 4241411, 4241331, 4241391, 4241531, 4241541, 4241731, A61K 39395
Patent
active
056793464
ABSTRACT:
A hybridoma cell line produced by the fusion of NS-1 myeloma cells with spleen cells obtained from mice immunized with Leukocyte Adhesion Molecule-1 (LAM-1) cDNA transfected cells. The cell line produces a monoclonal antibody reactive with human, monkey, cow, rabbit, sheep, dog, cat, pig and goat LAM-1. The monoclonal antibody produced by the cell line, anti-LAM1-3, may be clinically useful in blocking leukocyte entry into sites of inflammation or tissue injury.
REFERENCES:
patent: 5098833 (1992-03-01), Lasky et al.
patent: 5216131 (1993-06-01), Lasky et al.
Welpy et al. Biochimica et Biophysica Acta 1197:215-226 (1994).
Aruffo et al., "CD44 Is The Principal Cell Surface Receptor For Hyaluronate," Cell, 61, pp. 1303-1313 (1990).
Bevilacqua et al., "Identification of An Inducible Endothelial-Leukocyte Adhesion Molecule," Proc. Natl. Acad. Sci. USA 84:9238-9242 (1987).
Bevilacqua et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science 243:1160-1165 (1989).
Bevilacqua et al., "Selectins: A Family of Adhesion Receptors," Cell 67:233 (1991).
Bowen et al., "Characterization of a Human Homologue of the Murine Peripheral Lymph Node Homing Receptor," J. Cell Biol. 109:421-427 (1989).
Butcher et al., "Lymphocyte Adherence to High Endothelial Venules: Characterization of a Modified In Vitro Assay, and Examination of the Binding of Syngenic and Allogenic Lymphocyte Populations," J. Immunol. 123:1996-2003 (1979).
Camerini et al., "Leu-8/TQ-1 is the human equivalent of the Mel-14 lymph node homing receptor," Nature 342:78-82 (1989).
Carbone et al., "Expression of Leu-8 Surface Antigen in B-cell Lymphomas. Correlation with Other B-cell Markers," J. Pathol. 154:133-140 (1988).
Chin et al., "Lymphocyte Recognition of Lymph Node Endothelium. I. Inhibition of In Vitro Binding by a Component of Thoracic duct Lymph," J. Immunol. 125:1764-1769 (1980).
Chin et al., "Lymphocyte Recognition of Lymph Node High Endothelium. II. Characterization of an In Vitro Inhibitory Factor Isolated by Antibody Affinity Chromatography," J. Immunol. 125:1770-1774 (1980).
Chin et al., "Lymphocyte Recognition of Lymph Node High Endothelium. V. Isolation of Adhesion Molecules from Lysate of Rat Lymphocytes," J. Immunol. 131:1368-1374 (1983).
Flaherty et al., "A Monoclonal Antibody (MAB) To L-selectin Does Not Prevent Neutrophil (PMN) Emigration-Into An Inflamed Peritoneal Cavity," FASEB, 6, p. A1889 (1992).
Gatenby et al., "Dissection of Immunoregulatory Subpopulations of T Lymphocytes within the Helper and Suppressor Sublineages in Man," J. Immunol. 129:1997-2000 (1982).
Harlow et al., Antibodies: A Laboratory Manual, Cold Spring Harbor (1988); pp. 72-77, 92-97, 128-135, 141-157.
Harris et al., "Therapeutic Antibodies The Coming Of Age," TIBTECH, 3:99-121 (1993).
Jutila et al., "Characterization of a Functionally Important and Evolutionarily Well-Conserved Epitope Mapped to the Short Consensus Repeats of E-Selectin and L-Selectin," J. Exp. Med. 175:1565-1573 (1992).*
Kanof et al., "Induction of CD4 Suppressor T Cells With Anti-Leu-8 Antibody," J. Immunol. 139:49-64 (1987).
Kanof et al., "Leu-8 Antigen Expression is Diminished During Cell Activation But Does Not Correlate With Effector Function of Activated T Lymphocytes," J. Immunol. 140:3701-3706 (1988).
Kansas et al., "Maturational and Functional Diversity of Human. B Lymphocytes Delineated with Anti-Leu-8," J. Immunol. 134:3003-3006 (1985).
Kansas et al., "Molecular Mapping of Functional Domains of the Leukocyte Receptor for Endothelium, LAM-1," J. Cell Biol. 114:351-358 (1991).
Kishimoto et al., "Antibodies Against Human Neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 Antigen) and Endothelial Cell ELAM-1 Inhibit a Common CD18-Independent Adhesion Pathway In Vitro," Blood 78:805-811 (1991).
Kurk et al., "Characterization of an Endothelial Cell Antigen Recognized by an Anti-Leukocyte Homing Receptor (L-Selectin) Monoclonal Antibody," FASEB J. 6:A1192 (1992).
Morrison S.L., "Transfectomas Provide Novel Chimeric Antibodies" Science 229:1202-1207 (1985).
Ord et al., "Structure of the Gene Encoding the Human Leukocyte Adhesion Molecule-1 (TQ1, Leu-8) of Lymphocytes and Neutrophils," J. Biol. Chem. 265:7760-7767 (1990).
Picker et al., "The Neutrophil Selectin LECAM-1 Presents Carbohydrate Ligands to the Vascular Selectins ELAM-1 and GMP-140," Cell 66921-933 (1991).
Queen et al., "A Humanized Antibody that Binds to the Interleukin 2 Receptor" Proc. Natl. Acad. Sci. USA 86:10029-10033 (1989).
Reinherz et al., "Heterogeneity of Human T4 Inducer T cells Defined by a Monoclonal Antibody that Delineates Two Functional Subpopulations," J. Immunol. 128:463-468 (1982).
Spertini et al., "Regulation of Leukocyte Adhesion Molecule-1 (TQ1, Leu-8) Expression and Shedding by Normal and Malignant Cells," Leukemia 5:300-308 (1991).
Spertini et al., "Regulation of Leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin," Nature 349:691-694 (1991).
Spertini et al., "Function and Evolutionary Conservation of Distinct Epitopes on the Leukocyte Adhesion Molecule-1 (TQ,-1, Leu-8) that Regulate Leukocyte Migration," J. Immunol. 147:942-949 (1991).
Stoolman, "Adhesion Molecules Controlling Lymphocyte Migration," Cell 56:907-910 (1989).
Streeter et al., "Immunohistologic and Functional Characterization of a Vascular Addressin Involved In Lymphocyte Homing into Peripheral Lymph Nodes" J. Cell Biol. 107:1853-1862 (1988).
Tedder et al., "Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation," Eur. J. Immunol. 20:1351-1355 (1990).
Tedder et al., "Isolation and Chromosomal Localization of cDNAs Encoding a Novel Human Lymphocyte Cell Surface Molecule, LAM-1," J. Exp. Med. 170:123-133 (1989).
Tedder et al., "Expression of the Human Leukocyte Adhesion Molecule, LAM-1: Identity with the TQ1 and Leu-8 Differentiation Antigens," J. Immunol. 144:532-540 (1990).
Vedder et al., "Inhibition Of Leukocyte Adherence By Anti-CD18 Monoclonal Antibody Attenuates Reperfusion Injury In The Rabbit Ear," PNAS, 87, pp. 2643-2646 (1990).
Walcheck et al., "Characterization of the Bovine Peripheral Lymph Node Homing Receptor: A Lectin Cell Adhesion Molecule (LECAM)," Eur. J. Immunol., 22:469-476 (1992).
Waldmann T.A., "Monoclonal Antibodies In Diagnosis and Therapy" Science, 252:1657-1662 (1991). and
Wu et al., "Evolutionary Conversation of Tissue-specific Lymphocyte-Endothelial Cell Recognition Mechanisms Involved In Lymphocyte Homing," J. Cell Biol., 107:1845-1851 (1988).
Spertini Olivier G.
Tedder Thomas F.
Dana-Farber Cancer Institute
Feisee Lila
Gambel Phillip
Gunnison Jane T.
Haley, Jr. James F.
LandOfFree
Methods of blocking adhesion with anti-lami-3 antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of blocking adhesion with anti-lami-3 antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of blocking adhesion with anti-lami-3 antibody will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1004599