Methods of assessing the effect of a gene of interest on...

Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...

Reexamination Certificate

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C800S008000, C800S009000, C435S366000, C424S009200, C424S093210

Reexamination Certificate

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06949690

ABSTRACT:
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.

REFERENCES:
Liu, A. Y., et al., “Prostatic Cell Lineage Markers: Emergence of BCL2+Cells of Human Prostate Cancer Xenograft LuCaP 23 Following Castration,”Int. J. Cancer, 65:85-89 (1996).
Lubaroff, D. M., et al., “Survival of Human Prostate Carcinoma, Benign Hyperplastic Prostate Tissues, and IL-2-Activated Lymphocytes in SCID Mice,”The Prostate, 27:32-41 (1995).
Wainstein, M. A., et al., “CWR22: Androgen-Dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma,”Cancer Research, 54:6049-6052 (1994).
Pretlow, T.G., et al., “Xenografts of Primary Human Prostatic Carcinoma,”Journal of the National Cancer Institute, 85(5):394-398 (1993).
Pretlow, T. G., et al., “Transplantation of Human Prostatic Carcinoma into Nude Mice in Matrigel,”Cancer Research, 51:3814-3817 (1991).
Perez-Stable et al.,Cancer Research, vol. 57, pp. 900-906. (Mar. 1, 1997).
Sato et al.,Journal of Urology, vol. 155, 5, p. 338A. (May 4, 1996).
van Weerden et al.,American Journal of Pathology, vol. 149: 3, pp. 1055-1062. (Sep. 1996).
Aldrovandi, Grace M. et al., “The SCID-hu Mouse as a Model for HIV-1 Infection,”Nature, Jun. 24, 1993, 363:732-6.
Batson, Oscar V., “The Role of the Vertebral Veins in Metastatic Processes,”Ann. Int. Med., 1942, 16:38-45. (Exhibit 10).
Berrettoni, Beth A. and John R. Carter, “Current Concepts Review Mechanisms of Cancer Metastasis to Bone,”The Journal of Bone and Joint Surgery, 1986, 68A:308-312. (Exhibit 11).
Brandt, Burkhard et al., “Isolation of Prostate-Derived Single Cells and Cell Clusters From Human Peripheral Blood,”Cancer Research, Oct. 15, 1996, 56:4556-61. (Exhibit 12).
Coman, Dale Rex and Robert P. DeLong, “The Role of the Vertebral System in the Metastasis of Cancer to the Spinal Column,”Cancer, 1951, 4:610-8. (Exhibit 13).
Deguchi, T. et al., “Detection of Micrometastatic Prostate Cancer Cells in the Bone Marrow of Patients with Prostate Cancer,”British Journal of Cancer, 1997, 75(5):634-8. (Exhibit 14).
Ellis, William J. et al., “Characterization of a Novel Androgen-Sensitive, Prostate-Specific Antigen-Producing Prostatic Carcinoma Xenograft: LuCap 23,”Clinical Cancer Research, Jun. 1996, 2:1039-48. (Exhibit 15).
Fidler, Isaiah J., “Critical Factors in the Biology of Human Cancer Metastasis: Twenty-Eight G.H.A Clowes Memorial Award Lecture,”Cancer Research, Oct. 1, 1990, 50:6130-8. (Exhibit 16).
Ghossein, Ronald A. et al., “Detection of Circulating Tumor Cells in Patients with Localized and Metastatic Prostatic Carcinoma: Clinical Implications,”Journal of Clinical Oncology, May 1995, 13(5):1195-200. (Exhibit 17).
Gleave, Martin E. et al., “Serum Prostate Specific Antigen Levels in Mice Bearing Human Prostate LNCaP Tumors are Determined by Tumor Volume and Endocrine and Growth Factros,”Cancer Research, Mar. 15, 1992, 52:1598-605. (Exhibit 18).
Haq. Mahmudul et al., “Rat Prostate Adenocarcinoma Cells Disseminate to Bone and Adhere Preferentially to Bone Marrow-Derived Endothelial Cells,”Cancer Research, Sep. 1, 1992, 52:4613-9. (Exhibit 19).
Hsieh, J.T. et al., “An Androgen-Independent Model of Human Prostate Cancer Progression: Molecular and Cellular Characterization,”Proceedings of the American Association for Cancer Research, Mar. 1993, 34:248. (Exhibit 20).
Hsu, Su-Ming et al., “A Comparative Study of the Peroxidase-Antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies,”American Society of Clinical Pathologists, 1981, 75:734-8. (Exhibit 21).
Karp, Judith E. et al., “Prostate Cancer Prevention: Investigational Approaches and Opportunites,”Cancer Research, Dec. 15, 1996, 56:5547-56. (Exhibit 22).
Katz, Aaron E. et al., “Molecular Staging of Prostate Cancer with the Use of an Enhanced Reverse Transciptase-PCR Assay,”Urology, Jun. 1994, 43(6):765-75. (Exhibit 23).
Kjønniksen, Inge et al., “Validity and Usefulness of Human Tumor Models Established by Intratibial Cell Inoculation in Nude Rats,”Cancer Research, Apr. 1, 1994, 54:1715-9. (Exhibit 24).
Kozlowski, James M. et al., “Prostate Cancer and the Invasive Phenotype: Application of New In Vivo and In Vitro Approaches,”Tumor Progression and Metastasis, 1988, 189-231. (Exhibit 25).
Marcelli, Marco et al., “Definition of the Human Androgen Receptor Gene Structure Permits the Identification of Mutations that Cause Androgen Resistance: Premature Termination of the Receptor Protein at Amino Acid Residue 588 Causes Complete Androgen Resistance,”Molecular Endocrinology, 1990, 909:1105-16. (Exhibit 26).
Melchoir, Sebastian W. et al., “Clinical Relevance of Prostate Cells in the Bone Marrow of Patients with Clinically Localized Carcinoma of the Prostate (CAP),”The Journal of Urology, 1997, 157:1718. (Exhibit 27).
Nagabhushan, Moolky et al., “CWR22: The First Human Prostate Cancer Xenograft with Strongly Androgen-Dependent and Relapsed Strains Both In Vivo and in Soft Agar,”Cancer Research, Jul. 1, 1996, 56:3042-6. (Exhibit 28).
Netland, Peter A. and Bruce R. Zetter, “Metastatic Potential of B16 Melanoma Cells after In Vitro Selection for Organ-specific Adherence,”The Journal of Cell Biology, Sep. 1985, 101:720-4. (Exhibit 29).
Nishijima, Yukiko et al., “Clinical Significance of the Vertebral Vein in Prostate Cancer Metastasis,”Adv. Exp. Med. Biol., 1992, 324:93-100. (Exhibit 30).
Noel, A. et al., “Basement Membrane Components (Matrigel) Promote the Tumorgenicity of Human Breast Adenocarcinoma MCF7 Cells and Provide an In Vivo Model to Assess the Responsiveness of Cells to Estrogen,”Biochemical Pharmacology, 1992, 43(6):1263-7. (Exhibit 31).
Pang, Shen et al., “Prostate Tissue Specificity of the Prostate-Specific Antigen Promoter Isolated from a Patient with Prostate Cancer,”Human Gene Therapy, Nov. 1995, 6:1417-26. (Exhibit 32).
Saiki, Randall K. et al., “Enzymatic Amplification of Beta-Globulin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia,”Science, 1895, 230:1350-4. (Exhibit 33).
Seiden, Michael V. et al., “Detection of Circulating Tumor Cells in Men with Localized Prostate Cancer,”Journal of Clinical Oncology, Dec. 1994, 12(12):2634-9. (Exhibit 34).
Sutherland, Richard W. et al., “Androgen Receptor Gene Mutations are Rarely Associated with Isolated Penile Hypospadias,”The Journal of Urology, 1996, 156:828-31. (Exhibit 35).
Thalmann, George N. et al., “Androgen-Independent Cancer Progression and Bone Metastasis in the LNCaP Model of Human Prostate Cancer,”Cancer Research, May 15, 1994, 54:2577-81. (Exhibit 36).
Wang, Min and Mark E. Stearns, “Isolation and Characterization of PC-3 Human Prostatic Tumor Sublines Which Preferentially Metastasize to Select Organs in S.C.I.D. Mice,”Differentiation, 1991, 48:115-25. (Exhibit 37).
Wood, David P. Jr. et al, “Identification of Bone Marrow Micrometastases in Patients with Prostate Cancer,”Cancer, 1994, 74:2533-40. (Exhibit 38).
Wu, His-Chin et al., “Derivation of Androgen-Independent Human LNCaP Prostatic Cancer Cell Sublines: Role of Bone Stromal Cells,”Int. J. Cancer, 1994, 57:406-12. (Exhibit 39).
Zetter, Bruce R. et al., “The Cellular Basis for Prostate Cancer Metastasis,”Adv. Exp. Med. Biol., 1992, 324:39-43. (Exhibit 40).
Scott, Gerald A., et al., “Expression of Plasminogen Activator Inhibitor Type 1 by Human Prostate Carcinoma Cells Inibits Primary Tumor Growth, Tumor-associated Angiogenesis, and Metastasis to Lung and Liver in an Athymic Mouse Mode,”J. Clin. Invest. (Dec

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