Methods of angioplasty and cardiac catheterization

Details Methods of angioplasty and cardiac catheterization Methods of angioplasty and cardiac catheterization

1996-10-11

2000-06-27

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514 77, 514 78, 514824, A61K 9127, A61K 31685

Patent

active

06080422&

ABSTRACT:
The present invention provides an improved mode of operation of an apparatus for angioplasty or cardiac catheterization, apparatus for angioplasty and cardiac catheterization, and method of angioplasty or cardiac catheterization. The improvement and improved mode of operation includes the step of administering a therapeutically effective amount of a lipid acceptor during angioplasty or cardiac catheterization of a subject with the apparatus or component thereof. The lipid acceptor is selected from the group consisting of a large liposome comprised of phospholipids substantially free of sterol and small acceptors. The effective period of time is in the range of about less than 1 minute to about two years from the time of the angioplasty or cardiac catheterization. The improved angioplasty or cardiac catheterization apparatus includes means for administering a therapeutically effective amount of a lipid acceptor, and optional co-administration means for administering the lipid acceptor and a diagnostic agent. The improved mode of operating an angioplasty or cardiac catheterization apparatus includes administering a therapeutically effective amount of a lipid acceptor from the apparatus or component thereof into a vessel of a subject by administration means. The invention further provides a method of diagnosing a side-effect of reverse transport of cholesterol from peripheral tissues to the liver in vivo accompanying parenteral administration of a multiplicity of large liposomes and small liposomes during a treatment period. The method includes the step of periodically assaying plasma atherogenic lipoprotein concentrations with an assay to obtain an assayed atherogenic lipoprotein concentration.

REFERENCES:
patent: 4812314 (1989-03-01), Barenholz et al.
patent: 5077056 (1991-12-01), Bally et al.
patent: 5204112 (1993-04-01), Hope et al.
patent: 5252263 (1993-10-01), Hope et al.
patent: 5376452 (1994-12-01), Hope et al.
patent: 5489611 (1996-02-01), Lee et al.
patent: 5556637 (1996-09-01), Hager et al.
patent: 5622715 (1997-04-01), Barenholz et al.
patent: 5741514 (1998-04-01), Barenholz et al.
patent: 5741517 (1998-04-01), Hager et al.
Daida et al., Prevention Of Restenosis After Percutaneous Transluminal Coronary Angioplasty By Reducing Lipoprotein (a) Levels With Low-Density Lipoprotein Apheresis, Jun. 1, 1994, vol. 73, No. 15, pp. 1037-1040.
Desmarais et al., Elevated Serum Lipoprotein(a) Is A Risk Factor For Clinical Recurrence After Coronary Balloon Angioplasty, Cirulation, vol. 91, No. 5, Mar. 1, 1995, pp. 1403-1409.
Groop et al., Lipoprotein(a) In Type 1 Diabetic Patients With Renal Disease, Original Articles, May 11, 1994, pp. 961-967.
Kokoglu et al., Elevated Serum Lp(a) Levels In The Early And Advanced Stages Of Breast Cancer, Cancer Biochem, Biophys., 1994, vol. 14, pp. 133-136.
Kuriyama et al., Low Levels Of Serum Apolipoprotein A I And A II In Senile Dementia, The Japanese Journal Of Psychiatry And Neurology, vol. 48, No. 3, 1994, pp. 589-593.
Sachs, Bernard A., et al., In Vivo Effects Of Inositol Phosphatide (Lipositol) In Serum Lipids And Atherosclerosis Of Hyperlipemic Rabbits, J. Appl. Physiol., 15:983-986, 1960.
Takahashi et al., Increased Concentrations Of Serum Lp(a) Lipoprotein In Patients With Primary Gout, Annals Of The Rheumatic Diseases 1995, vol. 54, pp. 90-93.
Tenda et al., The Relationship Between Serum Lipoprotein(a) And Restenosis After Initial Elective Percutaneous Transluminal Coronary Angioplasty, Japanese Circulation Journal, vol. 57, Aug., 1993, pp. 789-795.
Williams et al., Uptake of Endogenous Cholesterol By A Synthetic Lipoprotein, Elsevier Science Publishers B.V. (Biomedical Division), 1986, pp. 183-194.
Yamamoto et al., Serum Lipoprotein (a) Levels Before And After Subtotal Thyroidectomy In Subjects With Hyperthyroidism, Metabolism, vol. 44, No. 1 (Jan.), 1995, pp. 4-7.
Bangham et al., "Diffusion of Univalent Ions across the Lamallae of Swollen Phospholipids" J.Mol.Biol. pp 238-252 (May 6, 1965).
Davidson, et al., "Association and release of prostaglandin EI from liposomes" Biochim. Biophys. Acta 1327(1), pp 97-106 (1997).
Davidson, W.S., et al., "The effect of high density lipoprotein phospholipid acyl chain composition on the efflux of cellular free cholesterol" J. Biol. Chem. 270(11), 5882-590 (Mar. 1995).
De Caterina and Lenzi, "Prevention and therapy of vascular damage and endothelial dysfunction with hypocholesteremic agents" G. Ital. Cardiol. 28(2), 168-177 (Feb. 1998).
Farnier and Davignon, "Current and future treatment of hyperlipidemia: the role of statins" Am. J. Cardiol. 82(4B), 3J-10J (Aug. 27, 1998).
Gould, "New concepts and paradigms in cardiovascular medicine: the noninvasive management of coronary artery disease" Am. J. Med. 104(6A), 2S-175 (Jun. 22, 1998).
Hernandez-Perera, et al., "Effects of the 3 -hydroxy-3 -methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin- 1 and endothelial nitric oxide synthase in vascular endothelial cells" J. Clin. Invest. 101(12), pp 2711-2719 (Jun. 15, 1998).
Isele, et al., "Pharmacokinetics and body distribution of liposomal zinc phthalocyanine in tumor-bearing mice: influence of aggregation state, particle size, and composition" J. Pharm. Sci. 84(2), pp 166-173 (Feb. 1995).
Luscher, et al., "Lipids and endothelial function: effects of lipid-lowering and other therapeutic interventions" Curr. Opin. Lipidol. 7(4), 234-240 (Aug. 1996).
Ravid, et al., "Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia" Arch. Intern. Med. 158(9), pp 998-1004 (May 11, 1998).
Rodrigueza et al., Large versus small unilamellar vesicles mediate reverse cholesterol transport in vivo into two distinct hepatic metabolic pools. Implications for the treatment of atherosclerosis. Artenolscle. Thromb. Vasc. Biol. 17(10), 2132-2139 (Oct. 1997).
Rodrigueza, et al., Cholesterol mobilization and regression of atheroma in cholestrol-fed rabbits inducted by large unilamellar vesicles. Biochim. Biophys. Acta 1368(2), pp 306-320 (Jan. 19, 1998).
Sparks, et al., "Effect of cholesterol on the charge and structure of apolipoprotein A-I in recombinant high density lipoprotein particles" J. Biol. Chem. 268(31), 23250-23257 (Nov. 5, 1993).
Sparks, et al., "The charge and structural stability of apolipoprotein A-I in discoidal and spherical recombinant high density lipoprotein particles" J. Biol. Chem. 267(36), 25839-25847 (Dec. 25, 1992).
Tricerri, et al., "Conformation of apolipoprotein AI in reconstituted lipoprotein particles and particle-membrane interaction: effect of cholesterol" Biochim. Biophys. Acta 1391(1), pp 67-78 (Mar. 6, 1998).
A.I. Soloviev, et al., Phospholipid Vesicles (Liposomes) Restore Endothelium-Dependent Cholinergic Relaxation In Thoracic Aorta From Spontaneously Hypertensive Rats, Journal of Hypertension 1993; vol. 11; No. 6; pp. 623-627.
Adams CWM, Abdulla YH, Bayliss OB, Morgan RS: Modification of aortic atheroma and fatty liver in cholesterol-fed rabbits by intravenous injection of saturated and polyunsaturated lecithins. J Pathol Bacteriol 94:77-87, 1967.
Altman RFA, de Mendonia JM, Schaeffer GMV, Ramos de Souza J, Bandoli JG, da Silva DJ, Lopes CRN: Phospholipids in experimental atherosclerosis. Arzneim Forsch 24:11-16, 1974.
Aviram M, Williams KJ, Deckelbaum RJ: Macrophage cholesterol removal by triglyceride-phospholipid emulsions. Biochem Biophys Res Commun 155:709-713, 1988.
Aviram M, Williams KJ, McIntosh RA, Carpentier YA, Tall AR, Deckelbaum RJ: Intralipid infusion abolishes ability of human serum to cholesterol-load cultured macrophages. Arteriosclerosis 9:67-75, 1989.
Bally MB, Hope MJ, Mayer LD, Madden TD, Cullis PR: Novel procedures for generating and loading liposomal systems. In: Gregoriadis G, ed. Liposomes as drug carriers: recent trends and progress. Chichester, England: John Wiley & Sons Ltd., 1988. pp. 841-853.
Bialecki RA, Tulenko TN, Colucci WS: Cholesterol enrichment increases basal and agonist-stimulated calcium influx in rat vascular smooth muscle cells. J C

Affiliated with

Also associated with

Rating

Methods of angioplasty and cardiac catheterization does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of angioplasty and cardiac catheterization, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of angioplasty and cardiac catheterization will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1782031