Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Boron containing doai
Reexamination Certificate
2011-04-26
2011-04-26
Padmanabhan, Sreeni (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Boron containing doai
C514S075000, C514S120000, C568S002000, C568S006000, C568S008000, C568S013000, C568S017000
Reexamination Certificate
active
07932239
ABSTRACT:
Methods and compositions involving a class of boron-protected phenylphosphine agents having increased cell permeability and having improved chemical stability for treating or for preventing neuronal cell death-related diseases or conditions in a human or a non-human animal.
REFERENCES:
patent: 6706926 (2004-03-01), Brown et al.
Imamoto et al. 1990, Synthesis and Reactions of phosphine-boranes. J. Am. Chem. Soc. vol. 112, pp. 5244-5252.
Gourdel et al. 1993, Activation of Phosphines with borane. Tetrahedron Letters, vol. 34, No. 6, pp. 1011-1012.
Leautey et al. 2001, Synthesis of alpha-substituted beta-amidophosphines by diastereoselective alkylation. J. Org. Chem. vol. 66, No. 16, pp. 5566-5571.
Cheng C, et al., “Intravitreal sustained-release dexamethasone device in the treatment of experimental uveitis,” Invest. Opthalmol. Vis. Sci. 36:442-453 (1995).
Chetoni P, et al., “Ocular mini-tablets for controlled release of timolol: evaluation in rabbits,” J. Ocul. Pharmacol. Ther. 129:245-252 (1996).
Feist R, et al., “Effectiveness of apraclonidine and acetazolamide in preventing postoperative intraocular pressure spikes after extracapsular cataract extraction,” J. Cataract Refract. Surg. 21:191-195 (1995).
Geiger L, et al., “Reduced redox state allows prolonged survival of axotomized neonatal retinal ganglion cells,” Neuroscience 109:635-642 (2002).
Imamoto T, et al., “Phosphine oxides and lithium aluminum hydride-sodium borohydride-cerium(III) chloride: synthesis and reactions of phosphine-boranes” J. Am. Chem. Soc. 107:5301-5303 (1985).
Imamoto T, “Synthesis and reactions of new phospine-boranes,” Pure & Appl.Chem. 65:655-660 (1993).
Joshi A, “Microparticulates for ophthalmic drug delivery,” J. Ocul. Pharmacol. 10:29-45 (1994).
Levkovitch-Verbin H, et al., “Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats,” Invest. Ophthalmol. Vis. Sci. 43:402-410 (2002).
McCalden T & Levy M, “Retention of topical liposomal formulations on the cornea,” Experientia 46:713-715 (1990).
Meseguer G, et al., “Gamma scintigraphic comparison of eyedrops containing pilocarpine in healthy volunteers,” J. Ocular. Pharm. Ther. 12:481-488 (1996).
Nelson M, et al., “Ocular tolerability of timolol in Gelrite in young glaucoma patients,” J. Am. Optom. Assoc. 67:659-663 (1996).
Rampal J, et al., “Carbon-phosphorus heterocycles. Synthesis and conformational analysis of alkyl-substituted 1,2,6-triphenyl-4-phosphorinanones and derivatives,” J Am. Chem. Soc. 46:1166-1172 (1981).
Levin Leonard A.
Raines Ronald T.
McMillian Kara R
Padmanabhan Sreeni
Quarles & Brady LLP
Wisconsin Alumni Research Foundation
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