Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-11-01
1994-12-20
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 79, 435 792, 435 7021, 43524027, 436501, 436503, 436530, 436531, 436548, 436811, 5303881, G01N 3353
Patent
active
053745299
ABSTRACT:
Methods of and compositions for early diagnosis, monitoring and treatment of osteoarthritis using monoclonal antibodies which specifically recognize antigenic determinants on atypical chondroitin sulfate/dermatan sulfate glycosaminoglycan chains in body tissues and fluids, which determinants are markers of osteoarthritis.
REFERENCES:
patent: 4704356 (1987-11-01), Thonar
patent: 4778768 (1988-10-01), Heinegard et al.
Rizkalla et al. , "Studies of the Articular Cartilage Proteoglycan Aggrecan in Health and Osteoarthritis," J. Clin. Invest., vol. 90 (1992) pp. 2268-2277.
Sorrell et al., J. Immunol., vol. 140, No. 12 (1988), pp. 4263-4270.
Sorrell et al., J. Cell. Biol., vol. 105, p. 298a, Abstract 1681, (1987).
Adams et al., Journal of Rheumatology, vol. 14, pp. 107-109 (1987).
Cox et al., Biochimica et Biophysica Acta, vol. 840(2), pp. 228-234 (1985).
Vasan, N., Biochem. Journal, vol. 187, pp. 781-787 (1980).
Hjertquist et al., Chemical Abstracts, vol. 77:99267s (1972).
Bollet, A. J., Chemical Abstracts, vol. 68:11148j (1968).
S. L. Carney et al., "Electrophoresis of .sup.35 S-Labeled Proteoglycans on Polyacrylamide-Agarose Composite Gels and Their Visualization by Fluorography", Analytical Biochemistry, 156, pp. 38-44 (1986).
B. Caterson et al., "Identification of a Monoclonal Antibody that Specifically Recognizes Corneal and Skeletal Keratan Sulfate", Journal of Biological Chemistry, 258 (14) pp. 8848-8854 (1983).
B. Caterson et al., "Monoclonal Antibodies as Probes for Elucidating Proteoglycan Structures and Function", Biology of Proteoglycans, ed., T. Wright and R. Mecham, Academic Press, N.Y., pp. 1-26 (1987).
B. Caterson et al., "Monoclonal Antibodies Against Cartilage Proteoglycan and Link Protein", Articular Cartilage Biochemistry, ed., K. Kuettner et al., Raven Press, New York, pp. 59-73 (1986).
B. Caterson et al., "Production Characterization of Monoclonal Antibodies Directed Against Connective Tissue Proteoglycans", Fed. Proc. 44, pp. 386-393 (1985).
J. E. Christner et al., "Immunological Determinants of Proteoglycans", The Journal of Biological Chemistry, 255, (15) pp. 7102-7105 (1980).
J. R. Couchman et al., "Mapping by Monoclonal Antibody Detection of Glycosaminoglycans in Connective Tissue", Nature, 307, pp. 650-652 (1984).
A. L. DeBlas et al., "Detection of Antigens on Nitrocellulose Paper Immunoblots with Monoclonal Antibodies", Analytical Biochemistry, 133, pp. 214-219 (1983).
R. W. Farndale et al., "A Direct Spectrophotometric Microassay for Sulfated Glycosaminoglycans in Cartilage Cultures", Connective Tissue Research, 9, pp. 247-248 (1982).
M. J. Pond et al., "Experimentally-Induced Osteoarthritis in The Dog", Annals of the Rheumatic Diseases, 32, pp. 387-388 (1973).
A. Ratcliffe et al., "Cartilage Proteoglycan Binding Region and Link Protein", Biochem J., 213, pp. 371-378 (1983).
J. M. Sorrel et al., "Immunochemical Characterization and Ultrastructural Localization of Chondroitin Silfates and Keratan Sulfate in Embryonic Chick Bone Marrow", Cell and Tissue Research, 252, pp. 523.gtoreq.531 (1988).
Caterson Bruce
Hardingham Timothy E.
Haley, Jr. James F.
Kepplinger Esther M.
McDonell Leslie A.
Wolski Susan C.
LandOfFree
Methods of and compositions for diagnosis, monitoring and treati does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of and compositions for diagnosis, monitoring and treati, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of and compositions for diagnosis, monitoring and treati will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2385678