Chemistry: analytical and immunological testing – Including sample preparation
Patent
1987-06-25
1989-01-31
Richman, Barry S.
Chemistry: analytical and immunological testing
Including sample preparation
422 99, 422102, 422 61, 422 58, 118429, 425117, 425110, 249 83, A23G 120, B01L 300, B22D 1900, G01N 130
Patent
active
048015539
ABSTRACT:
A cassette for holding a tissue specimen comprises a body portion (10) and a separable portion (12) which snap together to enclose a specimen (42) in a mould space (54) of the cassette. The specimen (42) is located and oriented in the mould space (54) between a compliant base portion (14) and the separable portion (12). The specimen is processed by the successive application of processing fluids before being embedded in paraffin wax. The specimen is held in its oriented position on the cassette during processing and embedding, there being no handling or re-positioning of the specimen between processing and embedding. During embedding, molten wax is supplied to a container (56) in which the cassette is placed. Wax surrounds and embeds the specimen, the container base is then cooled to solidify a base layer of wax, allowing the remaining wax to be drained from the container, leaving the wax within the cassette to solidify and cool. After removal of the cassette from the container, portions of the cassette are stripped away to leave the embedded specimen ready for microtome sectioning.
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North John R.
Nowinski Stefan
Owen Stephen
Richman Barry S.
Santiago Amalia L.
Spencer Alan H.
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