Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-08-29
2006-08-29
Goldberg, Jeanine A. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C435S287100, C435S287200, C536S023100, C536S024300
Reexamination Certificate
active
07097976
ABSTRACT:
Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to an array designed to interrogate individual alleles. Genes whose transcription products are present in amounts that vary from expected are candidates for allelic imbalance, imprinting and imprinting errors.
REFERENCES:
patent: 6251601 (2001-06-01), Bao et al.
patent: 6368799 (2002-04-01), Chee
patent: 2001/0007749 (2001-07-01), Feinberg
Weber et al. “Extensive tissue-specific variation of allelic methylation in the lfg2 gene during mouse fetal development: relation to expression and imprinting” Mechanisms of Development. vol. 101, p. 133-141, Mar. 2001.
Choi J.D. et al., Microarray expressiohn profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes. Mamalian Genome (2001) vol. 12, pp. 758-764.
Mizuno Y. et al., Asb4, Ata3 and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray. Biochem. Biophys. Res. Commun. 2002 vol. 290, Issue 5, pp. 1499-1505.
Mei R. et al., Genome-wide detection of allelic imbalance using human SNPs and high density DNA arrays. Genome Research, 2000, vol. 10, pp. 1126-1137.
Lindblad-Toh K. et al., Loss-of-heterozygosity analysis of small-cell lung carcinomas using single nucleotide polymorphisms arrays. Nature Biotechnology, 2000, vol. 18, pp. 10011005.
Lee M.P. Genome-wide search of imprinted genes. http://lpg.nci.nih.gov/LPG/lee/proj2.
Affymetrix Inc.
Goldberg Jeanine A.
Wells Sandra E.
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