Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-02
1997-10-21
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 435174, 536 221, 536 231, 536 243, 536 2432, 536 2433, 530300, C12Q 168, C12Q 170, C12P 1934, C07H 2104
Patent
active
056795220
ABSTRACT:
A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
REFERENCES:
patent: 4794075 (1988-12-01), Ford et al.
patent: 4818685 (1989-04-01), Sirover et al.
patent: 5296231 (1994-03-01), Yarosh et al.
patent: 5459039 (1995-10-01), Modrich et al.
Jiricny et al. NAR 16: 7843-785 1988.
Revzin et al. Biotechniques 7:346 1989.
Pang et al., J., of Bacteriol. 163: 1007-1015 1985.
Preibe et al., J. of Bacteriol 170: 190-196, 1988.
Chen et al. Science 237: 1197, 1987.
Myles et al. Chemical Research in Toxicology 2: 197-226 1989.
Su et al. JBC 263: 6829-6835 1988.
Lahue et al. Science 245: 160-169 1989.
Lu et al. Genomics 14: 249-255 1992.
Au et al. JBC 267: 12142-12148 1992.
Lu et al. Cell 54: 805-812 1988.
Wu et al. J. of Bacteriol. 173: 1902-1910 1991.
Modrich, Molecular Mechanisms of DNA - Protein Interaction, 1986, NIH Grant, Abstract (Source: Crisp).
Myers et al., "Detection of Single Based Substitutions by Ribonuclease Cleavage at Mismatches in RNA:DNA Duplexes," Science 230:1242-1246 (1985).
Nelson et al., "Genomic Mismatch Scanning A New Approach to Genetic Linkage Mapping," Nature Genetics 4:11-19 (1993).
Pang et al., "Identification and Characterization of the mutL and mutS Gene Products of Salmonella typhimurium LT2," J. Bacteriology 163:1007-1015 (1985).
Priebe et al., "Nucleotide Sequence of the hexA Gene for DNA Mistmatch Repair in Streptococus pneumoniae and Homology of hexA to mutS of Escherichia coli and Salmonella typhimurium ," J. Bacteriology 170:190-196 (1988).
Quinones et al., "Expression of the Escherichia coli dna Q (mutD) Gene is Inducible," Mol. Gene Genet. 211:106-112 (1988).
Rayssiguier et al., "The Barrier to Recombination Between Escherichia coli and Salmonella typhimuruim is Disrupted in Mismatch-Repair Mutants," Nature 342:396-401 (1989).
Reenan and Kolodner, "Isolation and Characterization of Two Saccharomyces cervesiae Genes Encoding Homologs of the Bacterial HexA and MutS Mismatch Repair Proteins," Genetics 132:963-973 (1992).
Shen and Huang, "Effect of Base Pair Mismatches on Recombination Via the RecBCD Pathway," Mol. Gen. Genet. 218:358-360 (1989).
Su and Modrich, "Escherichia coli mutS-encoded Protein Binds to Mismatched DNA Based Pairs," Proc. Natl. Acad. Sci. USA83:5057-5061 (1986).
Su et al., "Gap Formation is Associated With Methyl-Directed Mismatch Correction Under Conditions of Restricted DNA Synthesis," Genome 31:104-111 (1989).
Su et al., "Mispair Specificity of Methyl-directed DNA Mismatch Correction in Vitro," J. Biol. Chem. 263:6829-6835 (1988).
Wilchele et al., Analytical Biochem. 171:1-32 (1988).
Welsh et al., "Isolation and Characterization of the Escherichia coli mush Gene Product," J. Biol. Chem. 262:15624-15629 (1987).
Adams et al., "The Biochemistry of the Nucleic Acids," Chapman & Hall pp. 221-223 (1986).
Au et al., "Escherichia coli mutY Gene Encodes An Adenine Glycosylase Active on G-A Mispairs," Proc. Natl. Acad. Sci. USA 86:8877-8881 (1989).
Au et al., "Escherichia coli mutY Gene Product is Required for Specific A-G C-G Mismatch Correction," Proc. Natl. Acad. Sci. USA 85:9163-9166 (1988).
Au et al., "Initiation of Methyl-directed Mismatch Repair," J. Biol. Chem. 267:12142-12148 (1992).
Bianchi and Radding, "Insertions, Deletions and Mismatches in Heteroduplex DNA Made by RecA Protein," Cell 35:511-520 (1983).
Chen and Sigman, "Chemical Conversion of a DNA-Binding Protein Into a Site-Specific Nuclease," Science 237:1197-1201 (1987).
Cooper et al., "Methyl-Directed Mismatch Repair is Bidirectional," J. Biol. Chem. 268:11823-11829 (1993).
Cotton et al., "Reactivity of Cytosine and Thymine In Single-Base-Pair Mismatches with Hydroxylamine and Osmium Tetroxide and Its Application to the Study of Mutations," Proc. Natl. Acad. Sci. USA 85:4397-4401 (1988).
Dasgupta and Radding, "Polar Branch Migration Promoted by recA Protein: Effect of Mismatched Base Pairs," Proc. Natl. Acad. Sci. USA 79:762-766 (1982).
Fang and Modrich, "Human Strand-Specific Mismatch Repair Occurs by a Bidirectional Mechanism Similar to That of the Bacterial Reaction," J. Biol. Chem. 268:11838-11844 (1993).
Fujii and Shimada, "Isolation and Characterization of cDNA Clones Derived from the Divergently Transcribed Gene in the Region Upstream from the Human Dihydrofolate Reductase Gene," J. Biol. Chem. 264:10057-10064 (1989).
Grilley et al., "Isolation and Characterization of the Escherichia coli mutL Gene Product," J. Biol. Chem. 264:1000-1004 (1989).
Grilley et al., "Mechanisms of DNA-Mismatch Correction," Mutation Research 236:253-267 (1990).
Grilley et al., "Bidirectional Excision in Methyl-Directed Mismatch Repair," J. Biol. Chem. 268:11830-11837 (1993).
Hennighausen and Lubon, "Interaction of Protein With DNA In Vitro," Guide to Molecular Cloning Techniques, Berger and Kimmel eds., 152:721-735 (1987).
Holmes et al., "Strand-specific Mismatch Correction In Nuclear Extracts of Human and Drosophila Melanogaster Cell Lines," Proc. Natl. Acad. Sci. USA 87:5837-5841 (1990).
Jiricny et al., "Mistmatch-containing Oligonuycleotide Duplexes Bound By the E. coli mutS-encoded Protein," Nucleic Acids Research 16:7843-7853 (1988).
Lahue et al., "Requirement for d(GATC) Sequences in Escherichia coli mutHLS Mismatch Correctiun," Proc. Natl. Acad. Sci. USA 84:1482-1486 (1987).
Lahue and Modrich, "DNA Mismatch Correction in a Defined System," Science 245:160-164 (1989).
Lahue and Modrich, "Methyl-directed DNA Mismatch Repair in Escherichia coli," Mutation Research 198:37-43 (1988).
Lu et al., "Repair of DNA Base-pair Mismatches in Extracts of Escherichia coli," Cold Spring Harbor Laboratory, Cold Spring Harbor Symposia on Quantitative Biology, XLIX:589-596 (1984).
Lu and Chang, "Repair of Single Base-Pair Transversion Mismatches of Escherichia coli in Vitro: Correction of Certain A/G Mismatches is Independent of dam Methylation and Host mutHLS Gene Functions," Genetics 118:593-600(1988).
Lu and Chang, "A Novel Nucelotide Excision Repair for The Conversion of An A/G Mismatch to C/G Base Pair in E. coli," Cell 54:805-812 (1988).
Lu, "Influence of GATC Sequences on Escherichia coli DNA Mismatch Repair In Vitro," J. Bacteriology 169:1254-1259 (1987).
Lu and Hsu, "Detection of Single DNA Base Mutations with Mismatch Repair Enzymes," Genomics 14:249-255 (1992).
Lu et al., "Methyl-directed Repair of DNA Base-pair Mismatches in Vitro," Proc. Natl. Acad. Sci. USA 80:4639-4643 (1983).
Marx, "DNA Repair Comes Into Its Own," Science 266:728-730 (1994).
Modrich, "Mechanisms and Biological Effects on Mismatch Repair," Ann. Rev. Genet. 25:229-253 (1991).
Modrich et al. "DNA Mismatch Correction," Ann. Rev. Biochem. 56:435-466 (1987).
Modrich, "Mismatch, Repair, Genetic Stability and Cancer," Science 266:1959-1960 (1994).
Modrich, "Methyl-directed DNA Mismatch Correction," J. Biol. Chem. 264:6597-6600 (1989).
Au Karin G.
Cooper Deani Lee
Lahue Robert S.
Modrich Paul L.
Su Shin-San
Duke University
Jones W. Gary
Rees Dianne
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