Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-02-09
2009-12-29
Landsman, Robert (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600
Reexamination Certificate
active
07638490
ABSTRACT:
Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation of amount of feeding, body weight and fat weight after administration of relaxin-3. This invention includes: a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing the polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of the polypeptide; a kit for screening; and an agent with a substance which inhibits expression of the polypeptide, such as a feeding-suppressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.
REFERENCES:
patent: 2002-345468 (2002-12-01), None
patent: 00/24891 (2000-05-01), None
patent: 01/48189 (2001-07-01), None
patent: 01/68862 (2001-09-01), None
patent: 02/31111 (2002-04-01), None
patent: 02/061087 (2002-08-01), None
patent: 03/030930 (2003-04-01), None
patent: 2004/082598 (2004-09-01), None
patent: 2004/112575 (2004-12-01), None
patent: 2005/014616 (2005-02-01), None
patent: 2005/075641 (2005-08-01), None
patent: 2005/124361 (2005-12-01), None
Summerlee AJS et al. Endocrinology 139(5):2322-2328, 1998.
Sunn N, et al. PNAS 99(3):1701-1706, Feb. 5, 2002.
M Matsumoto, et al. The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. Gene. 248. 183-189. 2000.
S Takeda, et al. Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Letters 520 (2002) 97-101.
R Bathgate, et al. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. J. Biol. Chem. 277(2). pp. 1148-1157. 2002.
BMC McGowan, et al. Central relaxin-3 administration causes hyperphagia in male wistar rats. Endocrinology. 146 (8). pp. 3295-3300. 2005.
C Liu, et al. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). J. Biol. Chem. 280 (1). pp. 292-300. 2005.
C Liu, et al. Relaxin-3/Insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR) 135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. Mol. Pharmacol. 67 (1). pp. 231-240. 2005.
K Boels, HC Schaller. Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor. British Journal of Pharmacology (2003) 140, 932-938.
P. Sinnayah, et al. Water drinking in rats resulting from intravenous relaxin and its modification by other dispogenic factors. Endocrinology. 140 (11). pp. 5082-5086. 1999.
B Spiegelman, et al. Obesity and the regulation of energy balance. Cell. vol. 104. pp. 531-543. 2001.
C. Liu et al., Identification of relaxin-3/ INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135, 2003, J.Biol.Chem., 278(50), p. 50754-64.
C. Liu et al., Identification of relaxin-3/ INSL7 as a ligand for GPCR142, 2003, J.Biol.Chem., 278(50), p. 50765-70.
R.A. Bathgate et al., Relaxin: new peptides, receptors and novel actions, 2003, Trends Endocrinol Metab, 14(5), p. 207-13.
H. Kizawa et al., Production of recombinant human relaxin 3 in AtT20 cells, 2003, Regul. Pept., 113(1-3), pp. 79 to 84.
S. Sudo et al., H3 relaxin is a specifc ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2, 2003, J. Biol.Chem., 278(10), p. 7855-62.
C.S. Samuel et al., Physiological or pathological—a role for relaxin in the cardiovascular system?, 2003, Curr.Opin. Pharmacol., 3(2), p. 152-8.
International Search Report issued Aug. 29, 2007 in the International (PCT) Application of which the present application is the U.S. National Stage.
Liu, et al., “Identification of Relaxin-3/INSL7 as an Endogenous Ligand for the Orphan G-protein-coupled Receptor GPCR135,” The Journal of Biological Chemistry, vol. 278, No. 50, Dec. 12, 2003, pp. 50754-50764.
Arai Tohru
Harada Kokichi
Hida Takayuki
Kosasa Michiko
Sawai Toru
Eisai R&D Managment Co., Ltd.
Landsman Robert
Wenderoth , Lind & Ponack, L.L.P.
LandOfFree
Methods of affecting feeding and weight in mammals by... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of affecting feeding and weight in mammals by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of affecting feeding and weight in mammals by... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4144697