Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Reexamination Certificate
2006-08-08
2006-08-08
Padmanabhan, Sreenivasin (Department: 1616)
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
C424S046000, C424S434000, C424S455000, C424S464000, C514S002600, C514S003100, C514S866000, C514S946000
Reexamination Certificate
active
07087215
ABSTRACT:
Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for administering the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth, which has been demonstrated to achieve peak plasma levels of the pharmaceutical agent in about thirty minutes.
REFERENCES:
patent: 4156719 (1979-05-01), Sezaki et al.
patent: 4582835 (1986-04-01), Lewis et al.
patent: 4614730 (1986-09-01), Hansen et al.
patent: 4661492 (1987-04-01), Lewis et al.
patent: 4673679 (1987-06-01), Aungst et al.
patent: 4900730 (1990-02-01), Miyauchi
patent: 5004611 (1991-04-01), Leigh
patent: 5053389 (1991-10-01), Balschmidt et al.
patent: 5230884 (1993-07-01), Evans et al.
patent: 5240932 (1993-08-01), Morimoto et al.
patent: 5292499 (1994-03-01), Evans et al.
patent: 5306483 (1994-04-01), Mautone
patent: 5376646 (1994-12-01), Pittrof et al.
patent: 5451408 (1995-09-01), Mezei et al.
patent: 5492688 (1996-02-01), Byron et al.
patent: 5514670 (1996-05-01), Friedman et al.
patent: 5569450 (1996-10-01), Duan et al.
patent: 5591713 (1997-01-01), Igari et al.
patent: 5629011 (1997-05-01), Illum
patent: 5653987 (1997-08-01), Modi et al.
patent: 5656277 (1997-08-01), Berlati et al.
patent: 5665700 (1997-09-01), Cho et al.
patent: 5690954 (1997-11-01), Illum
patent: 5747066 (1998-05-01), Pittrof et al.
patent: 5747445 (1998-05-01), Backstrom et al.
patent: 5981591 (1999-11-01), Deihl
patent: 6017545 (2000-01-01), Modi
patent: 6042811 (2000-03-01), Duan et al.
patent: 6090407 (2000-07-01), Knight et al.
patent: 6110486 (2000-08-01), Dugger, III
patent: 6193997 (2001-02-01), Modi
patent: 6214375 (2001-04-01), Modi
patent: 6221378 (2001-04-01), Modi
patent: 6225343 (2001-05-01), Behl et al.
patent: 6255502 (2001-07-01), Penkler et al.
patent: 6261539 (2001-07-01), Adjei et al.
patent: 6271200 (2001-08-01), Modi
patent: 6294153 (2001-09-01), Modi
patent: 6312665 (2001-11-01), Modi
patent: 6375975 (2002-04-01), Modi
patent: 6432383 (2002-08-01), Modi
patent: 6436367 (2002-08-01), Modi
patent: 6451286 (2002-09-01), Modi
patent: 6485706 (2002-11-01), McCoy et al.
patent: 6495120 (2002-12-01), McCoy et al.
patent: 6524557 (2003-02-01), Backstrom et al.
patent: 2003/0017119 (2003-01-01), Rabinowitz et al.
patent: 0 200 383 (1986-12-01), None
patent: 0 272 097 (1988-06-01), None
patent: WO 96/36352 (1996-11-01), None
patent: WO 96/40057 (1996-12-01), None
patent: WO 97/42938 (1997-11-01), None
patent: WO 99/22703 (1999-05-01), None
patent: WO 99/40932 (1999-08-01), None
patent: WO 00/18371 (2000-04-01), None
patent: WO 0/037051 (2000-06-01), None
patent: WO 00/47203 (2000-08-01), None
patent: WO 00/56291 (2000-09-01), None
patent: WO 01/17506 (2001-03-01), None
patent: WO 01/87268 (2001-11-01), None
Worsley et al, Inhaled Fentanyl as a method of analgesia, 1990, The Association of Anesthetists of Gt Britain and Ireland, vol. 45, pp. 449-451.
Editor Alfonso R. Gennaro, Remington's Pharmaceutical Sciences, 17 Edition, 1985, pp. 293-297 & 1662-1677, Mack Publishing Company, Easton, Pennsylvania 18042.
Dieter Kohler, Systemic Therapy with Aerosols, Aerosols in Medicine: Principles, Diagnosis and Therapy, 2nd rev. ed., pp. 303-319, 1993 Elsevier Science Publishers BV.
Vincent HL Lee et al., Mucosal Penetration Enhancers for Facilitation of Peptide and Protein Drug Absorption, Critical Reviews in Therapeutic Drug Carrier Systems, pp. 91.139.140. 8(2):91-192 (1991).
John S. Patton. et al., Pulmonary Delivery of Peptides and Proteins, Advanced Drug Delivery Reviews, pp. 179-196, 8 (1992), Elsevier Science Publishers BV.
Hans Schreier et al., Pulmonary Delivery of Liposomes, Journal of Controlled Release, pp. 209-223, 24 (1993) Elsevier Science Publishers BV.
Amir H. Shojaei, Buccal Mucosa as a Route for Systemic Drug Delivery: A Review, J Pharm Pharmaceut Sci, 1 (1):1:15-30, 1998.
CK Oh et al., Biopharmaceutic Aspects of Buccal Absorption of Insulin, Meth Find Exp Clin Pharmacol 1990: 12(3):205-212.
Bruce J. Aungst, Comparison of the Effects of Various Transmucosal Absorption Promoters on Buccal Insulin Delivery, International Journal of Pharmaceutics, 53 (1989) 227-235.
Bruce J. Aungst et al., Comparison of Nasal, Rectal, Buccal, Sublingual and Intramuscular Insulin Efficiency and the Effects of a Bile Salt Absorption Promoter, The Journal of Pharmacology and Experimental Therapeutics, vol. 244, No. 1, pp. 23-27, 1988.
Bruce J. Aungst et al., Site Dependence of Absorption-Promoting Actions of Laureth-9, Na Salicylate, Na2EDTA and Aprotinin on Rectal, Nasal and Buccal Insulin Delivery, Pharmaceutical Research, vol. 5, No. 5, 1988. pp. 305-308.
Parkpoom Pengamnuay et al., Bile Salt-Fatty Acid Mixed Micelles as Nasal Absorption Promoters of Peptides, II. In Vivo Nasal Absorption of Insulin in Rats and Effects of Mixed Micelles on the Morphological Integrity of the Nasal Mucosa, Pharmaceutical Research, vol. 7, No. 4, 1990, pp. 370-375.
Generex Pharmaceuticals Incorporated
Haghighatian Mina
Hamilton Brook Smith & Reynolds P.C.
Padmanabhan Sreenivasin
LandOfFree
Methods of administering and enhancing absorption of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of administering and enhancing absorption of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of administering and enhancing absorption of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3676973