Methods of activating NKT cells

Details Methods of activating NKT cells Methods of activating NKT cells

2011-08-16

2011-08-16

Ewoldt, Gerald (Department: 1644)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C514S025000, C514S054000

Reexamination Certificate

active

07998739

ABSTRACT:
Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided.

REFERENCES:
patent: 6531453 (2003-03-01), Taniguchi et al.
patent: 2003/0157135 (2003-08-01), Tsuji et al.
patent: 2004/0127429 (2004-07-01), Tsuji
patent: 0988860 (2000-03-01), None
patent: 2006/029010 (2006-03-01), None
Zhou (Curr. Protein and Peptide Science, 7: 325-333, 2006).
Xia et al (Organic Letters, 8(24): 5493-5496, 2006).
Bendelac et al (Annual Review of Immunology, 25: 297-336, 2007).
Cantu et al. (Journal of Immunology, 2003, 170: 4673-4682).
Cochran et al (Immunity 2000, 12: 2341-250).
Vassan et al (Int. Immunol. 2007, 19(8): 943-951).
Beaudoin, L. et al., Immunity (2002) 17:725-736.
Bendelac, A. et al., Nat. Rev. Immunol. (2001) 1:177-186.
Bendelac, A., Nat. Immunol. (2004) 5:557-558.
Benlagha, K. et al., J. Exp. Med. (2000) 191:1895-1903.
Brigl, M. et al., Annu. Rev. Immunol. (2004) 22:817-890.
Brigl, M. et al., Nat. Immunol. (2003) 4:1230-1237.
Cantu, C. et al., J. Immunol. (2003) 170:4673-4682.
Chiu, Y.H. et al., Nat. Immunol. (2002) 3:55-60.
Conzelmann, E. et al., Adv. Exp. Med. Biol. (1980) 125:295-306.
Dabrowski, J. et al., Biochemistry (1980) 19:5652-5658.
De Libero, G. et al., News Physiol. Sci. (2003) 18:71-76.
De Libero, Springer Semin. Immunopathol. (2000) 22:219-238.
Fischer, K. et al., Proc. Natl. Acad. Sci. USA (2004) 101:10685-10690.
Galili, U. et al., Subcell Biochem. (1999) 32:79-106.
Gumperz, J.E. et al., Immunity (2000) 12:211-221.
Hogquist, K.A. et al., Cell (1994) 76:17-27.
Honey, K. et al., Nat. Immunol. (2002) 3:1069-1074.
Kang, S.J. et al., Nat. Immunol. (2004) 5:175-181.
Kawano, T. et al., Science (1997) 278:1626-1629.
Keusch, J.J. et al., J. Biol. Chem. (2000) 275:25308-25314.
Kitamura, H. et al., “The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells,” J. Exp. Med. (1999) 189:1121-1127.
Ohshima, T. et al., Proc. Natl. Acad. Sci USA (1997) 94:2540-2544.
Park, S.-H. et al., J. Immunol. (1998) 160:3128-3134.
Park, S.H. et al., Nature (2000) 406:788-792.
Prigozy, T.I. et al., Science (2001) 291:664-667.
Sandhoff, K. et al., Phils. Trans. R. Soc. Lond. B. Biol. Sci. (2003) 358:847-861.
Sango, K. et al., Nat. Genet. (1996) 14:348-352.
Sheikh, K.A. et al., Proc. Natl. Acad. Sci. USA (1999) 96:7532-7537.
Smyth, M.J. et al., Nature Immunology (2001) 1:459:460.
Stanic, A.K. et al., Proc. Natl Acad. Sci USA (2003) 100:1849-1854.
Teneberg, S. et al., Glycobiology (2004) 14:187-196.
Van Der Vliet, H.J.J. et al., “Effects of α-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Vα24+Vβ11+T cells,” Immunology (1999) 98:557-563.
Winau, F. et al., Nat. Immunol. (2004) 5:169-174.
Wu, D.Y. et al., J. Exp. Med. (2003) 198:173-181.
Yamashita, T. et al., Proc. Natl. Acad. Sci USA (2003) 100:3445-3449.
Zhou, D. et al., Science (2004) 303:523-527.
Zhou, X.T. et al., Org. Lett. (2002) 4:1267-1270.
Godfrey, D.I. et al., “The elusive NKT cell antigen—is the search over?” Science (2004) 306(5702):1687-1689.
Ogiso, M. et al., “Characterization of neutral glycosphingolipids in rat lens,” Exp. Eye Res. (1995) 60:193-198.
Zhou, D. et al., “Lysosomal glycosphingolipid recognition by NKT cells,” Science (2004) 306:1786-1789.
Smyth, M.J. et al., “NKT cells—conductors of tumor immunity?” Curr. Opin. Immunol. (2002) 14(2):165-171.
Van Dommelen, S.L.H. et al., “Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cells,” J. Virology (2003) 77(3):1877-1884.
Yu, K.O.A. et al., “Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides,” Proc. Natl. Acad. Sci. (2005) 102(9):3383-3388.
Goodman & Gilman's The Pharmacological Basis of Therapeutics, Tenth Edition, Hardman and Limbird, editors, The McGraw-Hill Companies, Inc., New York (2001) 54-56.
Gupta, R.K. et al., “Adjuvants—a balance between toxicity and adjuvanticity,” Vaccine (1993) 11(3):293-306.

Affiliated with

Also associated with

Rating

Methods of activating NKT cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of activating NKT cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of activating NKT cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2760716