Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-03-20
1994-06-28
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514186, 514460, A01N 5502, A01N 4316, A61K 31555, A61K 3135
Patent
active
053247205
ABSTRACT:
Inhibition of renal cancer, melanoma, colon cancer, lung cancer and leukemia cells by administration of compounds from the bafilomycin and hygrolidin groups of compounds.
REFERENCES:
patent: 854174 (1892-03-01), Holt et al.
patent: 4385065 (1983-05-01), Albers-Schoenberg
patent: 4390546 (1983-06-01), Goetz
patent: 4558139 (1985-12-01), Hagenmaier
Wilton et al "PD 118,576: A New Antitumor Macrolide Antibiotic" J of Antibiotics, vol. 28, No. 11, pp. 1449-1452, 1985.
Huang, et al., Discovery, Production and Purification of the Na.sup.+,D.sup.+ Activated ATPase Inhibitor, L-681,110 from the Fermentation Broth of Streptomyces SP. MA-5038, Journal of Antibiotics., vol. 37, No. 9, pp. 970-975 (1984).
Goetz, et al., L-155,175: A New Antiparasitic Macrolide Fermentation, Isolation and Structure, Journal of Antibiotics, vol. 38, No. 2, pp. 161-168 (1985).
M. R. Boyd, Status of the NCI Preclinical Antitumor Drug Discovery Screen, Principles and Practices of Oncology, vol. 3, No. 10 (1989).
Hensens, et al., Structure of the Sodium and Potassium Ion Activated Adenosinetriphosphatase Inhibitor L-681,110, J. Am. Chem. Soc., vol. 105, pp. 3672-3679 (1983).
Suzukake, et al., Inhibition of Pinocytosis by Hygrolidin Family Antibiotics, J. of Antibiotics, vol. 44, No. 3, pp. 344-348 (Mar. 1991).
Holt Tom G.
Monaghan Richard L.
Daniel Mark R.
DiPrima Joseph F.
Merck & Co. , Inc.
Muthard David A.
Nutter Nathan M.
LandOfFree
Methods of achieving antitumor activity using 16-membered-macrol does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of achieving antitumor activity using 16-membered-macrol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of achieving antitumor activity using 16-membered-macrol will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2377573