Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-03-20
1994-04-26
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514186, 514450, 514460, A01N 4302, A61K 31335
Patent
active
053067169
ABSTRACT:
Inhibition of renal cancer, melanoma, colon cancer, lung cancer and leukemia cells by administration of compounds from the bafilomycin and hygrolidin groups of compounds.
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patent: 4558139 (1985-12-01), Hagenmaier
Wilton et al "PD 118,576: A New Antitumor Macrolide Antibiotic" J. of Antibiotics vol. 28, No. 11, pp. 1449-1452, 1985.
Huang, et al., Discovery, Production and Purification of the Na.sup.+,D.sup.+ Activated ATPase Inhibitor, L-681,110 from the Fermentation Broth of Streptomyces SP. MA-5038, Journal of Antibiotics., vol. 37, No. 9, pp. 970-975 (1984).
Goetz, et al., L-155,175: A New Antiparasitic Macrolide Fermentation, Isolation and Structure, Journal of Antibiotics, vol. 38, No. 2, pp. 161-168 (1985).
M. R. Boyd, Status of the NCI Preclinical Antitumor Drug Discovery Screen, Principles and Practices of Oncology, vol. 3, No. 10 (1989).
Hensens, et al., Structure of the Sodium and Potassium Ion Activated Adenosinetriphosphatase Inhbitor L-681,110, J. Am. Chem. Soc., vol 105, pp. 3672-3679 (1983).
Suzukake, et al., Inhibition of Pinocytosis by Hygrolidin Family Antibiotics, J. of Antibiotics, vol. 44, No. 3, pp. 344-348 (Mar. 1991).
U.S. Ser. No. 07/854,167 filed Mar. 20, 1992 to Holt, et al.
Holt Tom G.
Monaghan Richard L.
Daniel Mark R.
DiPrima Joseph F.
Merck & Co. , Inc.
Muthard David A.
Nutter Nathan M.
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