Methods involving changing the constitutive and stimulated...

Details Methods involving changing the constitutive and stimulated... Methods involving changing the constitutive and stimulated...

1999-07-02

2001-09-25

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S045000, C424S464000, C424S489000, C424S430000, C424S431000, C424S432000, C424S434000

Reexamination Certificate

active

06294188

ABSTRACT:

1. GENERAL CONCEPTS OF THE INVENTION
This invention covers novel methods of treating several conditions of women by changing the constitutive and stimulated secretions of the local reproductive system including the uterine, uterine cervix, fallopian tubular secretions and vaginal secretions, secretions of the Bartholin or vestibular glands and urethral secretions. This invention also covers agents which can influence the function of the mucus genes found in the reproductive system, including, but not limited to the cervix, uterus, and Bartholin's glands and other parts of the reproductive system with mucus secreting cells. Both squamous epithelium of the lower genital tract (vagina; for example) and epithelial cells of the upper reproductive tract (the various parts of the uterus, for example) are included in this invention. Included are methods to influence or change the secretary effects of the mucus genes and mucus secreting cells and cells that influence the properties of secretory and cell surface mucins of all the above mentioned glands of the reproductive system. Changing the hydration, viscosity or other properties or stimulating the secretions can have potential uses in a variety of conditions and disorders, including, but not limited to contraception, infertility, menopause, dyspareunia, infections, and others related and unrelated conditions. Description of the function and anatomy of these organs can be found in Novak's Gynecology, 12
th
edition, eds. Berek, Adashi and Hillard, Williams and Wilkins, Baltimore, Md., 1996.


REFERENCES:
patent: 4139638 (1979-02-01), Neri et al.
patent: 4264582 (1981-04-01), Flora et al.
patent: 4344941 (1982-08-01), Wiechert et al.
patent: 4456600 (1984-06-01), Wiechert et al.
patent: 4501729 (1985-02-01), Boucher et al.
patent: 4558041 (1985-12-01), Wiechert et al.
patent: 4670427 (1987-06-01), Annen et al.
patent: 4684635 (1987-08-01), Orentreich et al.
patent: 4944949 (1990-07-01), Story et al.
patent: 5093133 (1992-03-01), Wisniewski et al.
patent: 5100918 (1992-03-01), Sunshine et al.
patent: 5292498 (1994-03-01), Boucher, Jr.
patent: 5294433 (1994-03-01), Singer et al.
patent: 5344651 (1994-09-01), Schwen et al.
patent: 5352699 (1994-10-01), Jackson
patent: 5364885 (1994-11-01), Ahluwalia et al.
patent: 5369126 (1994-11-01), Doran et al.
patent: 5541172 (1996-07-01), Labrie et al.
patent: 5635160 (1997-06-01), Stutts, III et al.
patent: 5654337 (1997-08-01), Roentsch et al.
patent: 5719197 (1998-02-01), Kanios et al.
patent: 5777134 (1998-07-01), Bakshi et al.
patent: 5811111 (1998-09-01), McAtee et al.
patent: 5837289 (1998-11-01), Grasela et al.
patent: 5853751 (1998-12-01), Masiz
patent: 5854230 (1998-12-01), Tannabe et al.
patent: 5863560 (1999-01-01), Osborne
patent: 5874095 (1999-02-01), Deckner et al.
patent: 5879701 (1999-03-01), Audett et al.
patent: 5885597 (1999-03-01), Botknecht et al.
patent: 5888523 (1999-03-01), Galask et al.
patent: 6015806 (2000-01-01), Labrie et al.
patent: 0 159 012 A2 (1985-10-01), None
Audie, et al., “Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization,”J. Histochem. Cytochem.41(10):1479-85 (1993).
Audie, et al., “Mucin gene expression in the human endocervix,”Hum. Reprod.10(1):98-102 (1995).
Chretien, “Ultrastructure and variations of human cervical mucus during pregnancy and the menopause,”Acta Obstet. Gynecol. Scand.57(4):337-48 (1978).
Dunson, et al., “Timing of oneset of contraceptive effectiveness in Norplant implant users. Part I. Changes in cervical mucus,”Fertil. Steril.69(2):258-66 (1998).
Fordney-Settlage, “A review of cervical mucus and sperm interactions in humans,”Int. J. Fertil.26(3):161-9 (1981).
Gipson, et al., “Mucin genes expressed by human female reproductive tract epithelia,”Biol. Reprod.56(4):999-1011 (1997).
Gorodeski & Hopfer, “Regulation of the paracellular permeability of cultured human cervical epithelium by a nucleotide receptor,”J. Soc. Gynecol. Investig.2(5):716-20 (1995).
Katz, “Human cervical mucus: research update,”Am. J. Obstet. Gynecol.165(6 Pt 2):1984-6 (1991).
Kopito, et al., “Water and electrolytes in human cervical mucus,”Fertil. Steril.24(7):499-506 (1973).
Moghissi, “The function of the cervix in fertility,”Fertil. Steril.23(4):295-306 (1972).
Petta, et al., “Timing of onset of contraceptive effectiveness in Depo-Provera users: Part I. Changes in cervical mucus,”Fertil. Steril.69(2):252-7 (1998).
Slomiany, et al., “Enhancement in the protective qualities of gastic mucus by ebrotidine during duodenal ulcer healing,”Gen. Pharmacol.26(5):1039-44 (1995).
Slomiany, et al., “Gastroprotective properties of ebrotidine. A review,”Arzneimittelforschung.47(4A):459-67 (1997).

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