Methods for using monoclonal antibodies specific for cell-surfac

Details Methods for using monoclonal antibodies specific for cell-surfac Methods for using monoclonal antibodies specific for cell-surfac

1995-06-07

1997-01-21

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

53038822, 53038873, 53038875, 43524027, A61K 39395, C07K 1628, C12N 520

Patent

active

055957374

ABSTRACT:
A shed form of leukocyte adhesion molecule-1 (LAM-1, L-selectin) is present in high levels in human plasma. Quantitative methods of detecting shed LAM-1 (sLAM-1) by Western blot and ELISA analysis are disclosed. Also disclosed are methods for the specific detection of cell-surface bound LAM-1 in the presence of shed LAM-1 and for immunotherapy using monoclonal antibodies reactive with cell-surface bound LAM-1 but not reactive with shed LAM-1.

REFERENCES:
patent: 4840793 (1989-06-01), Todd, III et al.
patent: 4959302 (1990-09-01), Cornaby et al.
patent: 5002873 (1991-03-01), St. John et al.
patent: 5098833 (1992-03-01), Lasky et al.
Harris & Emery, TIBTECH vol. N:44-46 1993.
Springer, "Adhesion receptors of the immune system," Nature 346:425-434 (1990).
Kishimoto et al., "Identification of a human peripheral lymph node homing receptor: A rapidly down-regulated adhesion molecule," Proc. Natl. Acad. Sci. USA 87:2244-2248 (1989).
Ley et al., "Lectin-Like Cell Adhesion Molecule1 Mediates Leukocyte Rolling in Mesenteric Venules in Vivo," Blood 77:2553-2555 (1991).
Spertini et al., "Leukocyte Adhesion Molecule (LAM-1, L-Selectin) Interacts with an Inducible Endothelial Cell Ligand to Support Leukocyte Adhesion," J. Immunol. 147:2565-2573 (1991).
Bowen et al., "Characterization of a Human Homologue of the Murine Peripheral Lymph Node Homing Receptor," J. Cell Biol. 109:421-427 (1989).
Siegelman et al., "Human homologue of mouse lymph node homing receptor: Evolutionary conservation at tandem cell interaction domains," Proc. Natl. Acad. Sci. USA 86: 5562-5566 (1989).
Tedder et al., "Isolation and Chromosomal Localization of cDNAs Encoding a Novel Human Lymphocyte Cell Surface Molecule, LAM-1," J. Exp. Med. 170: 123-133 (1989).
Gallatin et al., "A cell-surface molecule involved in organ-specific homing of lymphcytes," Nature 304: 30-34 (1983).
Lasky et al., "Cloning of a Lymphocyte Homing Receptor Reveals a Lectin Domain," Cell 56: 1045-1055 (1989).
Siegelman et al., "Mouse Lymph Node Homing Receptor cDNA Clone Encodes a Glycoprotein Revealing Tandem Interactions Domains," Science 243: 1165-1172 (1989).
Bevilacqua et al., "Identification of an inducible endothelial-leukocyte adhesion molecule," Proc. Natl. Acad. Sci. USA 84:9238-9243 (1987).
Bevilacqua et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science 243: 1160-1164 (1989).
Luscinskas et al., "Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium," J. Immunol. 142: 2257-2263 (1989).
Luscinskas et al., "Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1," J. Immunol. 146: 1617-1625 (1991).
Geng et al., "Raped neutrophil adhesion to activated endothelium mediated by GMP-140," Nature 323: 757-760 (1990).
Johnston et al., "Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation," Cell 56: 1033-1044 (1989).
Larsen et al., "PADGEM Protein: A receptor that mediates the Interaction of activated platelets with neutrophils and monocytes," Cell 59: 305-312 (1989).
Larsen et al., "PADGEM-Dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III(CD 15), " Cell 63: 467-474 (1990).
Collins et al., "Structure and Chromosomal Location of the Gene for Endothelial-Leukocyte Adhesion Molecule 1," J. Biol. Chem. 266: 2466-2473 (1991).
Johnston et al., "Structure of the Human Gene Encoding Granule Membrane Protein-140, a Member of the Selectin Family of Adhesion Receptors for Leukocytes,"J. Biol. Chem. 265: 21381-21385 (1990).
Ord et al., "Structure of the Gene Encoding the Human Leukocyte Adhesion Molecule-1 (TQ1, Leu-8) of Lymphocytes and Neutrophils," J. Biol. Chem. 265: 7760-7767 (1990).
Watson et al., "Genomic Organization of the Selectin Family of Leukocyte Adhesion Molecules on Human and Mouse Chromosome 1," J. Exp. Med. 172: 263-272 (1990).
Griffin et al., "Granulocyte-Macrophage Colony-Stimulating Factor and Other Cytokines Regulate Surface Expression of the Leukocyte Adhesion Molecule-1 on Human Neutrophils, Monocytes, and their Precursors," J. Immunol. 145: 576-584 (1990).
Tedder et al., "Expression of the Human Leukocyte Adhesion Molecule, LAM-1: Identity with the TQ1 and Leu-8 Differentiation Antigens," J. Immunol. 144: 532-540 (1990).
Tedder et al., "Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation," Eur. J. Immunol. 20: 1351-1355 (1990).
Imai et al., "Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor," J. Cell Biol. 113: 1213-1221 (1991).
Spertini et al., "Regulation of Leukocyte Adhesion Molecule-1 (TQ1, Leu-8) Expression and Shedding by Normal and Malignant Cells," Leukemia 5: 300-308 (1991).
Stamper et al., "Lymphocyte homing into lymph nodes: In vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules," J. Exp. Med. 144: 828-833 (1976).
Hallmann et al., "The peripheral lymph node homing receptor, LECAM-1, is involved in CD18-independent adhesion of human neutrophils to endothelium," Biochem. Biophys. Res. Comm. 174: 236-243 (1991).
Jutila et al., "Function and Regulation of the Neutrophil MEL-14 Antigen in vivo: Comparison with LFA-1 and MAC-1," J. Immunol. 143:3318-3324 (1989).
Lewinsohn et al., "Leukocyte-endothelial cell recognition: Evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes," J. Immunol. 138: 4313-4321 (1987).
Smith et al., "Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro," J. Clin. Invest. 87: 609-618 (1991).
Watson et al., "Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-lgG chimaera," Nature 349: 164-167 (1991).
Kansas et al., "Molecular Mapping of Functional Domains of The Leukocyte Receptor for Endothelium, LAM-1," J. Cell Biol. 114: 351-358(1991).
Stoolman et al., "Homing Receptors on Human and Rodent Lymphocytes-Evidence for a Conserved Carbohydrate-Binding Specificity," Blood 70: 1842-1850 (1987).
Yednock et al., "Receptors involved in Lymphocyte Homing: Relationship between a carbohydrate-binding Receptor and the MEL-14 Antigen," J. Cell Biol. 104: 725-731 (1987).
Yednock et al., "Phosphomannosyl-derivatized beads detect a receptor involved in lymphocyte homing," J. Cell Biol. 104: 713-724 (1987).
Siegelman et al., "The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: Role of the EGF domain in endothelial binding," Cell 61: 611-622 (1990).
Spertini et al., "Function and Evolutionary Conservation of Distinct Epitopes on the Leukocyte Adhesion Molecule-1 (TQ1, Leu-8) that Regulate Leukocyte Migration," J. Immunol. 147: 942-949 (1991).
Watson et al., "The complement binding-like domains of the murine homing receptor facilitate lectin activity," J. Cell Biol. 115: 235-243 (1991).
Jung et al., "Rapid Modulation of Homing Receptors (gp90.sup.MEL-14) Induced by Activators of Protein Kinase C," J. Immunol. 144: 130-136 (1990).
Kishimoto et al., "Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors," Science 245: 1238-1241 (1989).
Chin et al., "Lymphocyte Recognition of Lymph Node High Endothelium. I. Inhibition of an In Vitro Binding by a Component of Thoracic Duct Lymph," J. Immunol. 125: 1764-1769 (1980).
Chin et al., "Lymphocyte Recognition of Lymph Node High Endothelium, II. Characterization of an In Vitro Inhibitory Factor Isolated by Antibody Affinity Chromatography," J. Immunol. 125: 1770-1774 (1980).
Chin et al., "Lymphocyte Recognition of Lymph Node High Endothelium, V

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