Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Reexamination Certificate
2007-08-28
2007-08-28
Huff, Sheela J. (Department: 1643)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
C424S133100, C424S141100, C424S145100, C530S387100, C530S387300, C530S388100, C435S069600
Reexamination Certificate
active
10327598
ABSTRACT:
The present invention provides canine heavy chain and light chain (both λ and κ) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised of the presently disclosed canine variable domain framework sequences and CDRs specific for an antigen obtained from antibodies from other than canines (preferably mouse). The invention also provides methods of making caninized antibodies and using them. This disclosure specifically describes caninized antibodies that are useful in the treatment of canine allergy. The general process of caninization permits the development of useful therapeutics, which includes but is not limited to allergy, osteosarcomma's and lymphomma's.
REFERENCES:
patent: 5595861 (1997-01-01), Garza
patent: 5622842 (1997-04-01), Hollis et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 5852183 (1998-12-01), Maeda et al.
patent: 1991083579 (1991-04-01), None
patent: 1991123489 (1991-05-01), None
patent: 1992040894 (1992-02-01), None
patent: 1997169795 (1997-06-01), None
patent: WO/01/77332 (2001-10-01), None
William E. Paul. Fundamental Immunology, 3rd Edition, 1993, pp. 292-295.
Rudikoff et al. Proc. Natl. Acad. Sci., USA, 79:1979-1983, 1982.
Tang et al., “Cloning and characterization of cDNAs encoding four different anine immunoglobulin y Chains” Veterinary Immunology and Immunopathology, 80 (2001) 259-270.
McCumber and Capra, “The Complete Amino-Acid Sequence of a Canine Mu Chain”, Molecular Immunology, vol. 16, pp. 565-570 (1979).
Wasserman and Capra, “Primary Structure of the Variable Regions of Two Canine Immunoglobulin Heavy Chains”, Biochemistry, vol. 16, No. 14 (1977).
Wasserman and Capra, “The Amino Acid Sequence of the Light Chain Variable Region of a Canine Myeloma Immunoglobulin: Evidence that the VK Subgroups Predated Mammalian Speciation”, Immunochemistry, vol. 15, pp. 303-305 (1978).
Patel et al, “Sequence of the dog Immunoglobulin Alpha and Epilson Constant Region Genes” Immunogenetics 1995, 41(5), 282-6.
Wasserman et al., “Amino Acid Sequence of the Fc Region of a Canine Immunoglobulin M: Interspecies Homology for the IgM Class”, Science 200 (4346) 1159-1161 (1978).
Wasserman et al., “Primary Structure of the Variable Regions of Two Canine Immunoglobulin Heavy Chains”, Biochemistry 16 (14) 3160-3168 (1977).
Gebhard D. et al., “Canine IgE Monoclonal Antibody Specific for a Filiarial Antigen: Production by a Canine×Murine Heterohybridoma using B cells from a clinically affected lymph node” Immunology, 1995, vol. 85, pp. 429-434.
Aiyappa Ashok
Guo Hongliang
Krah, III Eugene Regis
Lawton Robert
Blanchard David J.
Huff Sheela J.
IDEXX Laboratories, Inc.
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