Methods for using benzoxazines for treating asthma

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

5142305, 544101, 544105, A61K 31535

Patent

active

057007985

ABSTRACT:
Compounds of formula I ##STR1## wherein X.sup.a, X.sup.b, R, R.sup.1 and R.sup.2 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful as potassium channel openers for the treatment of urinary incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

REFERENCES:
patent: 3192208 (1965-06-01), Easton et al.
patent: 3225042 (1965-12-01), Dillard et al.
patent: 3763153 (1973-10-01), Krapcho et al.
patent: 3821377 (1974-06-01), Krapcho et al.
patent: 4892872 (1990-01-01), Tahara et al.
patent: 5270308 (1993-12-01), Shiraishi et al.
patent: 5278158 (1994-01-01), Tsuzuki et al.
patent: 5486515 (1996-01-01), Brown et al.
K. Russell et al., "A Highly Potent Series of Fluoroalkyl Benzoxazine Pyridine-N-Oxide Potassium Channel Opener," Bioorganic & Medicinal Chemistry Letters, 3(12), 2727-2728, 1993.
Ashely E. Fenwick "The Synthesis of 2,2-Bis(Trifluoromethyl)Benzopyran Derivatives: A New Route to an Important Class of Potassium Channel", Tetrahedron Letters, (1993), 34, No. 11, 1815-1818.
Hiroshi Koga et al. "Synthesis and Antihypertensive Activity of KC-399, A Benzopyran K+ Channel Opener with long Duration of Action and Less Tachycardia", Bioorganic & Medicinal Chemistry Letters, (1993), 3, No. 10, 2005-2010.
Derek R. Buckle et al. "Relaxant Activity of 4-Amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-Amido-2H-1-benzopyrans on Guinea Pig Isolated Trachealis", J. Med. Chem., (1990), 33, 3028-3034.
R. C. Small et al. "Potassium Channel Opening Drugs and the Airways", Brazilian J Med Biol Res, (1992) 25, 983-998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for using benzoxazines for treating asthma does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for using benzoxazines for treating asthma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for using benzoxazines for treating asthma will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1802892

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.