Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2006-10-31
2006-10-31
Nickol, Gary B. (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007240, C435S372000, C435S373000
Reexamination Certificate
active
07129037
ABSTRACT:
This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
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Albert Matthew L.
Bhardwaj Nina
Darnell Robert
Inaba Kayo
Steinman Ralph M.
Klauber & Jackson
Nickol Gary B.
The Rockefeller University
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