Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Reexamination Certificate
2006-10-03
2006-10-03
Yu, Misook (Department: 1642)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
C424S085200, C424S141100
Reexamination Certificate
active
07115261
ABSTRACT:
The invention teaches methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-tumor immunotherapeutic agent, such as a anti-tumor antigen antibody/cytokine fusion protein having a cytokine and a recombinant immunoglobulin polypeptide chain sufficient to elicit a cytokine-specific biological response.
REFERENCES:
patent: 5262520 (1993-11-01), Plow et al.
patent: 5650150 (1997-07-01), Gillies
patent: 5753230 (1998-05-01), Brooks et al.
patent: 5766591 (1998-06-01), Brooks et al.
patent: 5780426 (1998-07-01), Palladino et al.
patent: 6147060 (2000-11-01), Zasloff et al.
patent: WO97/45137 (1997-12-01), None
Xiang et al. (Cancer Research, Nov. 1997, vol. 57, No. 21, pp. 4948-4955).
Folkman, J. “Angiogenesis in cancer, vascular, rheumatoid and other disease”, Nature Medicine, vol. 1, No. 1, pp. 27-31, 1995.
Holmgren, L et al. (1995) “Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression”Nature Medicine1:149-153, Abstract only.
Folkman, J. (1995) “Angiogenesis in cancer, vascular, rheumatoid and other disease”Nature Medicine1:27-31.
O'Reilly, M.S. et al., (1994) “Angiostatin: A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases by a Lewis Lung Carcinoma”Cell79:315-328.
Kerbel, Robert S. (1997) “A cancer therapy resistant to resistance”Nature390:335-336.
Boehm, Thomas et al. (1997) “Antiangiogenic therapy of experimental cancer does not induce acquire drug resistance”Nature390:404-407.
Volpert, Olga V. (1998) “A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1”PNAS(USA) 95:6343-6348.
Brooks, Peter C. et al., (1994) “Requirement of Vascular Integrin αvβ3 for Angiogenesis”Science264:569-571.
Friedlander, Martin et al., (1995) “Definition of Two Angiogenic Pathways by Distinct αv Integrins”Science270 :1500-1502.
Brooks, Peter C. et al., (1994) “Integrin αvβ3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels”Cell79:1157-1164.
Becker, Jurgen C. et al., (1996) “T Cell-mediated Eradication of Murine Metastatic Melanoma Induced by Targeted Interleukin 2 Therapy”J. Exp. Med.183:2361-2366.
Xiang, Rong et al. (1997) “Elimination of Established Murine Colon Carcinoma Metastases by Antibody-Interleukin 2 Fusion Protein Therapy”Cancer Research57:4948-4955.
Lode, Holger N. et al.(1998) “Natural Killer Cell-Mediated Eradication of Neuroblastoma Metastases to Bone Morrow by Targeted Interleukin-2 Therapy”Blood91(5):1706-1715.
Irie, Reiko F. et al. (1989) “Human Monoclonal Antibody to Ganglioside GM2 For Melanoma Treatment”The Lancet1, 786-787.
Handgretinger, R. et al. (1995) “A Phase I Study of Human/Mouse Chimeric Anti-ganglioside GD2 Antibody ch14.18 in Patients with Neuroblastoma”European J. Cancer31 A(2):261-267.
Riethmuller, Gert et al. (1994) “Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma”The Lancet343:1177-83.
Gillies, Stephen D. (1992) “Antibody-targeted interleukin 2 stimulates T-cell killing of autologous tumor cells”Immunology89:1428-1432.
Gillies, Stephen D. (1998) “Antibody-IL-12 Fusion Proteins Are Effective in SCID Mouse Models of Prostate and Colon Carcinoma Metastases”The Journal of Immunology160:6196-6203.
Brooks, Peter C. et al. (1995) “Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in humna skin”J. Clin. Invest.96:1815-1822.
Mauceri, Helena J. et al. (1998) “Combined effects of angiostatin and ionizing radiation in antitumor therapy”Nature394:287-291.
Teicher, B.A. et al., “Potentiation of Cytotoxic Cancer Therapies by TNP-470 Alone . . . ” Int. J. Cancer, 1994; 57:920-925.
Kakeji, Y. et al., “Preclinical Studies of the Combination of Angiogenic Inhibitors with Cytotoxic Agents” Invest. New Drugs, 1997; 15:39-48.
Cheresh David A.
Gillies Stephen D.
Lode Holger N.
Reisfeld Ralph A.
EMD Lexigen Research Center Corp.
Olson & Hierl Ltd.
The Scripps Research Institute
Yu Misook
LandOfFree
Methods for treatment of tumors and metastases using a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for treatment of tumors and metastases using a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treatment of tumors and metastases using a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3680555