Methods for treatment of obesity and effective fat loss...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S456000

Reexamination Certificate

active

10660256

ABSTRACT:
Methods for treating obesity, reducing total weight and reducing body fat mass by administering a composition comprising dihydroquercetins and root-derived aralosides A, B, C and D is disclosed.

REFERENCES:
patent: 4451465 (1984-05-01), White et al.
patent: 4772631 (1988-09-01), Holloway et al.
patent: 4977148 (1990-12-01), Holloway et al.
patent: 4999377 (1991-03-01), Caulkett et al.
patent: 5626849 (1997-05-01), Hastings et al.
patent: 5783603 (1998-07-01), Majeed et al.
patent: 5804596 (1998-09-01), Majeed et al.
patent: 6340482 (2002-01-01), Jones
patent: 6827950 (2004-12-01), Hong et al.
patent: 2002-187845 (2002-07-01), None
Babenkova et al., Vestnik oftalmologii, (Jul.-Aug. 1999) vol. 115, No. 4, pp. 22-24.
Brasaemle et al., (1997) “Post-translational Regulation of Perillipin Expression”,The Journal of Biological Chemistry, 272:9378-9387.
Brasaemle et al. (2000) “Perilipin A Increases Triacylglycerol Storage by Decreasing the Rate of Triacylglycerol Hydrolysis”,The Journal of Biological Chemistry, 275:38486-38493.
Chaudhry and Granneman (1999) “Differential regulation of functional responses by β-adrenergic receptor subtypes in brown adipocytes”,Am. J. Physiol., 277:R147-R153.
Clifford et al., (1998) “Dephosphorylation of perilipin by protein phosphatases present in rat adipocytes”,FEBS Letters, 435:125-129.
Clifford et al., (2000) “Translocation of Hormone-sensitive Lipase and Perilipin upon Lipolytic Stimulation of Rat Adipocytes”,The Journal of Biological Chemistry, 275:5011-5015.
Geodakyan et al., (1992) “High-performance liquid chromatographic method for determination of mangiferin, likviritin and dihydroquercetin in rat plasma and urine”,J. of Chromatography, 577:371-375.
Greenberg et al. (1991) “Perilipin, a Major Hormonally Regulated Adipocyte-specific Phosphoprotein Associated with the Periphery of Lipid Storage Droplets”,The Journal of Biological Chemistry, 266:11341-11346.
Greenberg et al., (1993) “Isolation of cDNAs for perilipins A and B: Sequence and expression of lipid droplet-associated proteins of adipocytes”,Proc. Natl. Acad. Sci. USA, 90:12035-12039.
Han et al., (1998) “Norepinephrine-Augmenting Lipolytic Effectors fromAsitlbe thunbergiiRhizomes”,J. Nat. Prod., 61:1006-1011.
Haraguchi et al., (1996) “Inhibition of aldose reductase by dihydrofavonols inEngelhardtia chrysolepisand effects on other enzymes”,Experientia, 52: 564-567.
Haraguchi et al., (1996) “Protection against Oxidative Damage by Dihydroflavonols inEngelhardtia chrysolepis”, Biosci. Biotech. Biochem. 60:945-948.
Heymsfield et al., (1998) “Garcinia cambogia(Hydroxycitric Acid) as a Potential Antiobesity Agent: A Randomized Controlled Trial”,JAMA, 280:1596-1600.
Holm et al., (2000) “Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Liposlysis”,Annu. Rev. Nutr., 20:365-393.
Igarashi et al., (1996) “Effect of Astilbin in Tea Processed from Leaves ofEngelhardtia chrysolepison the Serum and Live Lipid Concentrations and on the Erythrocyte and Liver Antioxidative Enzyme Activities of Rats”,Biosci. Biotech. Biochem., 60:513-515.
Kellner-Weibel et al., (2001) “Evidence that newly synthesized esterified cholesterol is deposited in existing cytoplasmic lipid inclusions”,Journal of Lipid Research, 42:768-777.
Leonhardt et al., (2002) “Hydroxycitrate Has Long-Term Effects on Feeding Behavior, Body Weight Regain and Metabolism after Body Weight Loss in Male Rats”,J. Nutr., 132:1977-1982.
Londos et al., (1995) “Perilipin: unique proteins associated with intracellular neutral lipid droplets in adipocytes and steroidogenic cells”,Biochem. Society Transactions, 23:611-615.
Martinez-Botas et al., (2000) “Absence of perilipin results in leanness and reverses obesity in Leprdb/dbmice”,Nature Genetics, 26:474-479.
Mauriege et al., (1999) “Regional and gender variations in adipose tissue lipolysis in response to weight loss”,J. of Lipid Research, 40:1559-1571.
Miyase et al., (1996) “Araliasaponins XII-XVIII, triterpene saponins from the roots of Aralia chinensis”,Phytochemistry42:1123-1130.
Miyase et al., (1996) “Araliasaponins I-Xi, triterpene saponins from the roots of Aralia decaisneana”,Phytochemistry, 41:1411-1418.
Morimoto et al., (1997) “Norepinephrine-induced Lipolysis in Rat Fat Cells from Visceral and Subcutaneous Sites: Role of Hormone-sensitive Lipase and Lipid Droplets”,J. of Lipid Research, 38:132-138.
Morimoto et al., (2000) “Mechanism of the stimulatory action of okadaic acid on lipolysis in rat fat cells”,J. of Lipid Research, 41:199-204.
Morimoto et al., (2000) “Substrate-Dependent Lipolysis Induced by Isoproterenol”,Biochem and Biophys Res Comm, 274:631-634.
Morimoto et al., (2001) “Relationships between lipolysis induced by various lipolytic agents and hormone-sensitive lipase in rat fat cells”,J. of Lipid Research, 42:120-127.
Muls et al., (2001) “The effects of orlistat on weight and on serum lipids in obese patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled, multicentre study”,International Journal of Obesity, 25:1713-1721.
Murphy et al., (2000) “New insights into the mechanisms of lipid-body biogenesis in plants and other organisms”,Biochemical Society Transactions, 28:710-711.
Osterlund T. (2001) “Structure-function relationships of hormone-sensitive lipase”,Eur. J. Biochem., 268:1899-1907.
Sakai et al., (1994) “Oleanolic acid saponins from root bark of Aralia elata”,Phytochemistry, 35:1319-1324.
Satoh et al., (1994) “Oleanolic acid saponins from root-bark of Aralia elata”,Phytochemistry, 36:147-152.
Sedykh et al., (1986) “The Influence of the Aralia Mandshurica Tincture, Aminalon of Their Combination for Memorization of Texts”,New Medicinal Preparation from Plants of Siberia and the Far East, p. 132.
Servetnick et al., (1995) “Perilipins Are Associated with Cholesteryl Ester Droplets in Seroidogenic Adrenal Cortical and Leydig Cells”,The Journal of Biological Chem, 270:16970-16973.
Snow J.M. (1995) “Coleus forskohliiWilld. (Lamiaceae)”,The Protocol Journal of Botanical Medicine, pp. 39-42.
Souquet et al., (2000) “Phenolic Composition of Grape Stems”,J. Agric. Food Chem., 48:1076-1080.
Souza et al., (1998) “Overexpression of Perilipin A and B Blocks the Ability of Tumor Necrosis Factor α to Increase Lipolysis in 3T3-L1 Adipocytes”,The Journal of Biological Chemistry, 273:24665-24669.
Tansey et al., (2001) “Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity”,PNAS, 98:6494-6499.
Theriault et al., (2000) “Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid”,Journal of Lipid Research, 41:1969-1979.
Tiukavkina et al., (1997) “Dihydroquercetin—a new antioxidant and biologically active food additive”,Vopr Pitan, 6:12-15.
Wang et al., (1994) “Chemical analysis of main medicinal species of genus Aralia”,CHung Kuo Chung Yao Tsa Chih, 19:6-8.
Yamamoto et al., (2000) “Anti-obesity effects of lipase inhibitor CT-11, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet”,International Journal of Obesity, 24:758-764.
Yoshikawa et al., (1995) “Medicinal foodstuffs. I. Hypoglycemic constituents from a garnish foodstuff “taranome,” the young shoot ofAraliaelata SEEM: elatosides G, H, I, J. and K”,Chem Pharm Bull, 43:1878-1882.
Yoshikawa et al., (1996) “Bioactive saponins and Glycosides. VI. Elatosides A and B, Potent Inhibitors of Ethanol Absorption, from the Bark ofAralia elataSEEM. (Araliaceae): The Structure

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