Methods for treatment of male-pattern baldness

Details Methods for treatment of male-pattern baldness Methods for treatment of male-pattern baldness

1989-11-20

1991-10-01

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514171, 514175, 514177, 514178, 514181, A61K 3156

Patent

active

050534033

ABSTRACT:
Synergistic compositions for inhibiting the action of androgens comprise the combination in a single topical preparation of a 5.alpha.-reductase enzyme inhibitor and an androgen receptor blocking agent in a pharmaceutically and dermatologically acceptable vehicle. The compositions may be topically applied to affected areas of the skin in the treatment or prevention of sebaceous gland hypertrophy, hirsutism and male-pattern baldness in mammals. The inhibitor and blocking agent are present in the composition in a weight ratio of about 1:20 to 5:1, with the inhibitor comprising up to about 0.1% w/v of the comopsition and the blocking agent comprising up to about 1% w/v of the composition.

REFERENCES:
patent: 4684635 (1987-08-01), Orentreich et al.
Aron-Brunetiere-"Aspects of Endocrinological Treatment", Hair Research (1981) pp. 312-317.
Matias, J. R., Malloy, V. & Orentreich, N., "Animal Models of Androgen-Dependent Disorders of the Pilosebaceous Apparatus," Arch. Dermatol. Res., 281: 247-53 (1989).
Nielsen, P. G., "Treatment of Moderate Idiopathic Hirsutism with a Cream Containing Canrenone" (an Antiandrogen), Dermatologica, 165, pp. 636-639 (1982).
Rentoul, J. R., "Management of the Hirsute Woman," Intl. J. Derm., 22, pp. 265-72 (1983).

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