Methods for treatment of beta-amyloid protein-induced ocular...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai

Reexamination Certificate

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C514S912000

Reexamination Certificate

active

07728043

ABSTRACT:
The invention provides methods for treating beta-amyloid protein-involved ocular disease including age-related macular degeneration and glaucoma, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated fromCurcumasp.,Zingibersp.,Ginkgo biloba, Salviasp., andRosmarinussp. and synthetic chemical analogues thereof, for the treatment of a beta-amyloid protein-involved ocular disease.

REFERENCES:
patent: 5089636 (1992-02-01), Kwak et al.
patent: 5266344 (1993-11-01), Mimura et al.
patent: 5587358 (1996-12-01), Sukigara et al.
patent: 5861415 (1999-01-01), Majeed et al.
patent: 6887898 (2005-05-01), Kim
patent: 2004/0101578 (2004-05-01), Kim et al.
patent: 02-193930 (1990-07-01), None
patent: 07206669 (1995-08-01), None
patent: 08-040970 (1996-02-01), None
patent: 11246398 (1999-09-01), None
patent: WO 97/03674 (1997-02-01), None
patent: WO 98/51302 (1998-11-01), None
patent: WO 00/70949 (2000-11-01), None
patent: WO 01/30335 (2001-05-01), None
Artico et al., “Geometrically and Confromationally Restrained Cinnamoyl Compounds as Inhibitors of HIV-1 Integrase: Synthesis, Bioligical Evaluation, and Molecular Modeling,”J. Med. Chem., 41:3948-3960 (1998).
Beard, et al., “Nonsteroidal Anti-Inflammatory Drug Use and Alzheimer's Disease: A Case-Control Study in Rochester, MN 1980-1984,”Mayo Foundation for Medical Education and Research73(10), 951-955 (1998).
Behl et al., “Hydrogen Peroxide Mediates Amyloid β Protein Toxicity,”Cell77, 817-827 (1994).
Carr, et al., “Current Concepts in the Pathogenesis of Alzheimer's Disease,”The American Journal of Medicine, 103(3A), 3S-10S (1997).
Chang et al., “The Effect of Chinese Medicinal HerbZingiberis rhizomaExtract on Cytokine Secretion by Human Peripheral Blood Mononuclear Cells,”J. Ethnopharmacology, 48:13-19 (1995).
Clostre, “Ginkgo bilobaextract (EGb 761): A State of Art at the Dawn of the Third Millennium,” Annales Pharmaceutiques Francaises, 57, No. Suppl. 1:1S8-1S88 (1999).
Conney et al., “Inhibitory Effect of Curcumin and Some Related Dietary Compounds on Tumor Promotion and Arachidonic Acid Metabolism in Mouse Skin,”Advances in Enzyme Regulation, Proceedings of the Thirty-First Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues held at Indiana University School of Medicine, Weber, ed., vol. 31, pp. 385-396 (1991).
Cuajungco, et al., “Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders,”Neurobiology of Disease4, 137-169 (1997).
Davis, et al., “The Amyloid Beta-Protein of Alzheimer's Disease is Chemotactic for Mononuclear Phagocytes,”Biochemical and Biophysical Research Communications189(2) 1096-1100 (1992).
Friedlich et al., “Involvement of Free Oxygen Radicals in β-Amyloidosis: An Hypothesis,”Neurobiology of Aging15(4), 443-455 (1994).
Gellerman et al., “Antimicrobial Effects of Anacardic Acids,”Canadian Journal of Microbiology, 15:1219-1223 (1969).
Ghanta et al., “A Strategy for Designing Inhibitors of β-Amyloid Toxicity,”The Journal of Biological Chemistry271(47), 29525-29528 (1996).
Goedert, “Tau protein and the neurofibrillary pathology of Alzheimer's disease,”TINS16(11) 460-465 (1993).
Green et al., “Nuclear Estrogen Receptor-Independent Neuroprotection by Estratrienes: A Novel Interaction with Glutathione,”Neuroscience84(1), 7-10 (1998).
Haass et al., “Cellular Processing of β-Amyloid Precursor. Protein and the Genesis of Amyloid β-Peptide,”Cell75 10-39-1042 (1993).
Harkany et al., “Cholinotoxic effects of β-amyloid(1-42)peptide on cortical projections of the rat nucleusBasalis magnocellularis,” Brain Research695, 71-75 (1995).
He et al., “High-Performance Liquid Chromatography-Electrospray Mass Spectrometric Analysis of Pungent Constituents of Ginger,”J. Chromatography A, 796:327-334 (1998).
Hefti, “Development of Effective Therapy for Alzheimer's Disease Based on Neurotrophic Factors,”Neurobiology of Aging15(2), S193-S194 (1994).
Henderson, “The epidemiology of estrogen replacement therapy and Alzheimer's disease,”American Academy of Neurology48(5), S. 7, 275-355 (1997).
Hensley et al., “A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease,”PNAS USA91, 3270-3274 (1994).
Hertel et al., “Inhibition of the electrostatic interaction between β-amyloid peptide and membranes prevents β-amyloid-induced toxicity,”PNAS USA94, 9412-9417 (1997).
Hidalgo et al., “Determination of the Carnosic Acid Content in Wild and CultivatedRosmarinus officinalis,” J. Agric. Food. Chem46, 2624-2627 (1998).
Hiserodt et al., “Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition ofMycobacterium aviumandMycobacterium tuberculosis,” J. Agric. Food Chem., 46:2504-2508 (1998).
Hopia et al., “Effect of Different Lipid Systems on Antioxidant Activity of Rosemary Constituents Camosol and Carnosic Acid with and without α-Tocopherol,”J. Agric. Food Chem44, 2030-2036 (1996).
Hoshi et al., “Nontoxic Amyloid β Peptide1-42Suppresses Acetylocholine Synthesis,”The Journal of Biological Chemistry272(4), 2038-2041 (1997).
Huang et al., “Novel Bipheny Ether Liganans from the Rhizomes ofCurcuma chuanyujin,” Chem. Pharm. Bull, 48(8):1228-1229 (2000).
Ihara et al., “Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease,”J. Biochem99, 1807-1810 (1986).
Itokawa et al., “Antitumor Principles fromGinkgo bilobaL.,”Chem. Pharm.Bull., 35(7):3016-3020 (1987).
Jitoe et al., “Antioxidant Activity of Tropical Ginger Extracts and Analysis of the Contained Curcuminoids,”J. Agric. Food Chem40, 1337-1340 (1992).
Jung et al., “Effects of Curcumin on the Microglial Activation,”Yakhak Hoeji, 44(5):448-454 (2000).
Kelloff et al., “Chemopreventive Drug Development: Perspectives and Progress,”Cancer Epidemiol. Biomarkers&Prev., 3:85-98 (1994).
Khopde et al., “Free Radical Scavenging Ability and Antioxidant Efficiency of Curcumin and its Substituted Analogue,”Biophysical Chemistry, 80:85-91 (1999).
Kiergis et al., “Activation of Macrophages by Alzheimer β Amyloid Peptide,”Biochemical and Biophysical Research Communications199(2), 984-991 (1994).
Kihara et al., “Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity,”Brain Research792, 331-334 (1998).
Kikuzaki et al., “Antioxidant Effects of Some Ginger Constituents,”Journal of Food Science58(6), 1407-1410 (1993).
Kim et al.,“Inhibition of β-Amyloid Neurotoxicity in PC12 Cells by CLZ-1, CLZ-2 and CLZ-3 Isolated FromCurcuma longa, Zingiberaceae: An Approach Toward A Rational Drug Discovery of Anti-Alzheimer Disease,”Society for Neuroscience Abstracts, 24(1-2):1457 (1998).
Kim et al., “Curcuminoids fromCurcuma longaL. (Zingiberaceae) that Protect PC12 Rat pheochromocytoma and Normal Human Umbilical Vein Endothelial Cells from βA(1042) Insult,”Neuroscience Letters, 303:57-61 (2001).
Kim et al., “Shogaols fromZingiber officinaleProtect IMR32 Human Neuroblastoma and Normal Human Umbilical Vein Endothelial Cells from β-Amyloid (25-35) Insult,”Letter . . . Planta Med2002 68, 375-376 (2002).
Kumar et al., “The Acute Neurotoxic Effect of β-Amyloid on Mature Cultures of Rat Hippocampal Neurons is Attenuated by the Anti-Oxidant U-78517F,”Intern. J. Neuroscience79, 185-190

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