Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-09-28
2000-03-14
Moezie, F. T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 12, 514 21, 424 9463, 424 9464, 435 696, A61K 3836
Patent
active
060373229
ABSTRACT:
A method of treatment for patients with vascular occlusion and thromboembolic disorders including the acquired disease state of thrombotic stroke, by administering activated protein C. The administration of aPC provides a highly selective therapeutic agent with a low potential for causing bleeding complications. The administration of aPC is beneficial in preventing the local extension of the microvascular and macrovascular occluding arterial thrombus, thereby reducing the neurological deficit resulting from the stroke.
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Chabbat et al., Thromb. Haemost. 65: A1814, 1991 "The Behaviour of Human Activated Protein C in the Plasma of Different Laboratory Animals".
Frederick J. Walker, Thromb. Res. 22; 321-327, 1981 "Regulation of Bovine Activated Protein C by Protein S: The Role of the Cofactor Protein in Species Specificity".
Xuhua He, Bjorn Dahlback, Thromb. Haemost 71:446-451, 1994 "Rabbit Plasma, unlike Its Human Counterpart, Contains no Complex between Protein S and C4b-Binding Protein".
Ralph E. Weinstein and Frederick J. Walker, Thromb. Res. 63:123-131, 1991 "Species Specificity of the Fibrinoloytic Effects of Activated Protein C".
Andras Gruber and John H. Griffin, Blood 79:2340-2328, 1992 "Direct Detection of Activated Protein C in Blood From Human Subjects".
Grinnell Brian W.
Howey Daniel C
Jackson Charles V
Apelgren Lynn D.
Barrett Brian P.
Caltrider Steven P.
Eli Lilly and Company
Moezie F. T.
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