Methods for treating various disease states by reducing adhesion

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, A61K 3817

Patent

active

059487585

ABSTRACT:
The invention relates to therapeutic methods of using a substantially pure protein comprising the .beta.-subunit of a human glycoprotein involved in cellular adhesion, or a biologically active fragment thereof, or analog thereof. These therapeutic methods are useful for treating auto immune diseases and allograft rejection.

REFERENCES:
Anderson, D. C. et al., "The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features", J. Infect. Dis. 152:668-689 (1985).
Barbosa, J. A. et al., "Gene mapping and somatic cell hybrid analyses of the role of human lymphocyte function-associated antigen-3 (LFA-3) in CTL-target cell interactions", J. Immunol. 136:3085-3091 (Apr. 1986).
Botstein, D. et al., "Construction of a Genetic Linkage Map in Man Using Restriction Fragment Length Polymorphisms", Am. J. Hum. Genet. 32:314-331 (1980).
Gromkowski, S. H. et al., "Functional distinctions between the LFA-1, LFA-2, and LFA-3 membrane proteins on human CTL are revealed with trypsin-pretreated target cells", J. Immunol. 134:244-249 (1985).
Hildreth, J. E. K. et al., "The human lymphocyte function-associated (HLFA) antigen and a related macrophage differentiation antigen (HMac-1): functional effects of subunit-specific monoclonal antibodies", J. Immunol. 134:3272-3280 (1985).
Hildreth, J. E. K. et al., "A human lymphocyte-associated antigen involved in cell-mediated lympholysis", Eur. J. Immunol. 13:202-207 (1983).
Kishimoto, T. K. et al., "Cloning of the .beta. Subunit of the Leukocyte Adhesion Proteins: Homology to an Extracellular Matrix Receptor Defines a Novel Supergene Family", Cell 48:681-690 (Feb. 1987).
Kohl, S. et al., "The genetic deficiency of leukocyte surface glycoprotein Mac-1, LFA-1, p150,95 in humans is associated with defective antibody-dependent cellular cytotoxicity in vitro and defective protection against herpes simplex virus infection in vivo", J. Immunol. 137:1688-1694 (Sep. 1986).
Krensky, A. M. et al., "Human cytolytic T-lymphocyte clones and their function-associated cell surface molecules", in: Hybridoma Technology in the Biosciences and Medicine, Chapter 35, pp. 559-573 (1985).
Krensky, A. M. et al., "LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation", J. Immunol. 132:2180-2182 (1983).
Krensky, A. M. et al., "The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions", J. Immunol. 131:611-614 (1983).
Kurzinger, K. et al., "Structural homology of a macrophage differentiation antigen and an antigen involved in T-cell-mediated killing", Nature 296:668-671 (1982).
Lasky, L. A. et al., "Cloning of a Lymphocyte Homing Receptor Reveals a Lectin Domain", Cell 56:1045-1055 (1989).
Livingston, D. M., "Immunoaffinity Chromatography of Proteins", Meth. Enzymol. 34:723-731 (1974).
Martin, P. J. et al., "Identification and functional characterization of two distinct epitopes on the human T-cell surface protein Tp50", J. Immunol. 131:180-185 (1983).
Miller, L. J. et al., "Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation", J. Immunol. 137:2891-2900 (Nov. 1986).
Plunkett, M. L. et al., "Purification and characterization of the lymphocyte function-associated-2 (LFA-2) molecule", J. Immunol. 136:4181-4187 (Jun. 1986).
St. John, T. et al., "Expression cloning of a lymphocyte homing receptor cDNA: ubiquitin is the reactive species", Science 231:845-850 (Feb. 1986).
Sanchez-Madrid, F. et al., "A human leukocyte differentiation antigen family with distinct .alpha.-subunits and a common .beta.-subunit: The lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1) and the p195,95 molecule", J. Exp. Med. 158:1785-1803 (1983).
Sanchez-Madrid, F. et al., "Mapping of antigenic and functional epitopes on the .alpha.-and .beta.-subunits of two related mouse glycoprotein involved in cell interactions, LFA-1 and Mac-1", J. Exp. Med. 158:586-602 (1983).
Sanchez-Madrid, F., "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3", Proc. Natl. Acad. Sci. U.S.A. 79:7489-7493 (1982).
Shaw, S. et al., "Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones", Nature 323:262-264 (Sep. 1986).
Shuster, D. E. et al., "Identification and prevalence of a genetic defect that causes leukocyte adhesion definciency in Holstein cattle", Proc. Natl. Acad. Sci. U.S.A. 89:9225-9229 (1992).
Springer, T. A. et al., "The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system", Ann. Rev. Immunol. 5:223-252 (1987).
Springer, T. A. et al., "Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon", Nature 314:540-542 (1985).
Springer, T. A. et al., "Inherited LFA-1, Mac-1 definciency and its molecular biology", in: Mononuclear Phagocytes and Inflammation, Van Furth, R. et al., eds., Nijhoff, Dordrecht: Neth., pp. 115-123 (1985).
Springer, T. A. et al., "Inherited definciency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis", J. Exp. Med. 160:1901-1918 (1984).
Suggs, S. V. et al., "Use of synthetic oligonucleotides as hybridization probes: Isolation of cloned cDNA sequences for human .beta..sub.2- microglobulin", Proc. Natl. Acad. Sci. U.S.A. 78:6613-6617 (1981).
Wolf, M. et al., "Monoclonal antibodies to T11, LFA-2, and LFA-3 antigens inhibit binding of human thymocytes to autologous thymic epithelial cells", Clin. Research 34:674A (Apr. 1986).
Young, R. A. et al., "Yeast RNA polymerase II genes: Isolation with antibody probes", Science 222:778-782 (1983).
Anderson, D.C. et al., "Leukocyte LFA-1, OKM1, p150,95 deficiency syndrome: functional and biosynthetic studies of three kindreds," Fed. Proc., FASEB 44(10):2671-2677 (Jul. 1985).
Fischer, A. et al., "Prevention of Graft Failure by an Anti-HLFA-1 Monoclonal Antibody in HLA-Mismatched Bone-Marrow Transplantation," Lancet:1058-1061 (Nov. 1986).
Sastre, L. et al., "A partial genomic DNA clone for the .alpha. subunit of the mouse complement receptor type 3 and cellular adhesion molecue Mac-1," Proc. Natl. Acad. Sci. U.S.A. 83:5644-5648 (Aug. 1986).
Hynes et al. Cell 48, 549-554, 1987.
Alberts et al. Molecular Biology of the Cell. Garland Publishing, Inc., pp. 264-266, 1983.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for treating various disease states by reducing adhesion does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for treating various disease states by reducing adhesion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treating various disease states by reducing adhesion will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1804586

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.