Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1994-03-02
1999-01-05
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
4241781, 4241561, 4241831, 4241421, 4241551, 4241811, 5303917, 5303919, 5303871, 53038815, 53038822, 5303888, 5303913, A61K 5110, A61K 39395, C07K 1600
Patent
active
058558667
ABSTRACT:
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunologically-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
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Burrows Francis J.
Thorpe Philip E.
Board of Regenis, The University of Texas System
Hartley Michael G.
Kight John
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