Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1998-10-23
1999-08-03
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
A61K 3166
Patent
active
059325631
ABSTRACT:
New methods for treating patients with a traumatic contusion-type spinal cord injury are provided. The method comprises the steps of providing a patient having a contusion-type injury and administering liposomes containing dichloromethylene diphosphonate (hereinafter referred to as "Cl.sub.2 MBP") . The liposomes are preferably administered to the patient by intravenous injection. The liposomes are administered prior to the onset of infiltration of the spinal cord by the peripheral macrophages. Preferably, the liposomes are administered to the patient multiple times preferably during a period extending from 0 hours to seven days after occurrence of the injury. In a preferred embodiment, the liposomes are multilamellar phosphatidylcholine liposomes.
REFERENCES:
patent: 4009270 (1977-02-01), Gainer, Jr.
patent: 5030656 (1991-07-01), O'Brien et al.
patent: 5189018 (1993-02-01), Goldman et al.
patent: 5360797 (1994-11-01), Johnson et al.
patent: 5662918 (1997-09-01), Winter et al.
"Effects of silica on the outcome from experimental spinal cord injury: implication of microphages in secondary tissue damage" by Blight, AR, Neuroscience, 60:263-273, 1994.
"Liposome-mediated monocyte depletion during wallerian degeneration defines the role of hematogenous phagocytes in myelin removal" by Bruck, et al., J. Neurosci. Res. 46: 477-484, 1996.
"Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord" by Giulian, et al., Ann Neurol. 227: 33-42, 1990.
"Liposome mediaated affection of monocytes" by Huitinga, et al., Immunobiology, 185: 11-19, 1992.
"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications" by van Rooijen, et al., J. Immunol. Methods, 174: 83-93, 1994.
"Impantation of stimulated homologous macrophages results in partial recovery of paraplegic rats" by Rapalino, et al., Nature Medicine, vol. 4 No. 7, Jul. 1998, pp. 814-821.
"Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat" by Barhodi, et al., Brain Researh 672, 1995, pp. 177-186.
"Phagoctyic Response in Photochemically Induced Infarction of Rat Cerebral Cortex" by Schroeter, et al., Stroke, vol. 28 No. 2, Feb. 1997, pp. 382-386.
"Suppression of Experimental Allergic Encephalomyelitis in Lewis Rats After Elimination of Macrophages" by Huitinga, et al., J. Exp. Med., vol.. 172, Oct. 1990, pp. 1025-1033.
"Quinolinic acid accumulation and functional deficits following experimental spinal cord injury" by Blight, et al., Brain, 118, 1995, pp. 735-752.
"The Role of Macrophages, Perivascular Cells, and Microglial Cells in the Pathogenesis of Experimental Autoimmune Encephalomyelitis" by Bauer, et al. GLIA, 15:437-446 (1995).
"Cellular Inflammatory Response After Spinal Cord Injury in Sprague-Dawley and Lewis Rats" by Popovich,, et al., The Journal of Comparative Neurology, 377:443-464 (1997).
"Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine" by van Rooijen, et al., Journal of Immunological Methods, 193 (1996) pp. 93-99.
Abstract 155, "Circulating Macrophages as Pathological Effector Cells after Spinal Cord Injury" by Popovich, et al., Abstracts of the International Society for Neuroimmunology Fifth International Congress, Montreal, Canada, Aug. 23-27, 1998.
Abstract 130, "Selective Depletion of Peripheral Macrophages Attenuates Myelin Loss and Improves Hindlimb Function in Spinal Injures Rats" by Popovich, et al., Journal of Neurotrauma, vol. 14, No. 10, Oct. 1997.
Huitinga Inge
Popovich Phillip G.
Stokes Bradford T.
Van Rooijen Nico
Henley III Raymond
Ohio State Research Foundation
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