Methods for treating psychosis associated with glucocorticoid re

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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A61K 3156

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active

061503495

ABSTRACT:
This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for amelirating psychotic major depression. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods.

REFERENCES:
patent: 4814333 (1989-03-01), Ravaris
Van der Lely, Derwent Drug File, abstract No. 1993-29824, 1993.
Piazza et al, Chemical Abstracts, abstract No. 126:84476, 1996.
Behl et al, Chemical Abstracts, abstract No. 126:55042, 1997.
Beck C.A. et al. (1993) "The Steroid Antagonist RU486 Exerts Different Effects on the Glucocorticoid and Progesterone Receptors" Department of Pathology and Program in Molecular Biology, University of Colorado Health Sciences Center (S.K.N.D.P.E.) vol. 123, No. 2, pp. 728-740.
Chrousos, G.P. et al. (1989) "Clinical Applications of RU 486, a Prototype Glucocorticoid and Progestin Antagonist." In:Baulieu, E.E. and Segal, S.J. eds. The Antiprogestin Steroid RU 486 and Human Fertility Control. New York: Plenum Press, pp. 273-284.
F. Cadepond, Ph.D. et al., (1997) "RU486 (Mifepristone): Mechanisms of Action and Clinical Uses" Anna. Rev. Med. 1997, 48:129-56.
Krishnan, K.R.R.et al. (1992) "RU 486 in depression" Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 16:913-920.
Murphy, B.E.P. et al. (1993) "Possible Use of Glucocorticoid Receptor Antagonists in the Treatment of Major Depression: Preliminary Results Using RU 486" J. Psychiatr. Neurosci., 18:209-213.
Murphy, B.E.P. s(1997) "Antiglucocorticoid therapies in major depression: A review" Psychoneuroendocrinology, 22:s125-132.
Nieman, L.K. et al. (1985) "Successful treatment of Cushing's Syndrome with the Glucocorticoid Antagonist RU 486" J. Clin. Endocrinol. Metab., 61:536-540.
Rothschild, A.J. et al. (1982) "The Dexamethasone Suppression Test as a Discriminator among Subtypes of Psychotic Patients" Brit. J. Psychiat. 141:471-474.
Rothschild, A.J. et al. (1985) "The effects of a single acute dose of dexamethasone on monoamine and metabolite levels in rat brain" Life Sci. 36:2491-2501.
Sartor, O.et al. (1996) "Mifepristone: Treatment of Cushing's Syndrome" Clin. Obstetrics and Gynecol. 39:506-510.
Schatzberg, A.F. et al. (1983) "The Dexamathasone Suppression Test: Identification of Subtypes of Depression" Am. J. Psychiat., 140:88-91.
Schatzberg, A.F. et al. (1985) "A corticosteriod/dopamine hypothesis for psychotic depression and related states" J. Psychiat. Res., 19:57-64.
Schatzberg, A.F. et al. (1988) "The Roles of Glucocorticoid and Dopaminergic Systems in Delusional (Psychotic) Depression" Annals N.Y. Acad. of Sci., 537:462-471.
Van der Lely, A.J. et al. (1991) "Rapid Reversal of Acute Psychosis in the Cushing Syndrome with the Cortisol-Receptor Antagonist Mifepristone (RU 486)" Ann. Intern. Med., 114:143-144.
Van der Lely, A.J. (1993) Pharmacy World & Science, 15:89-90.

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