Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-11-29
1997-06-24
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435 691, 435 694, A61F 200, A61K 4700, A61K 31685
Patent
active
056417500
ABSTRACT:
The present invention relates generally to methods for treating injury or degeneration of retinal neurons, and in particular photoreceptors, by administering glial cell line-derived neurotrophic factor (GDNF). The invention relates specifically to methods for treating retinal conditions or diseases in which vision is lost such as retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, peripheral vitreoretinopathies, photic retinopathies, surgery-induced retinopathies, viral retinopathies, ischemic retinopathies, retinal detachment and traumatic retinopathy.
REFERENCES:
patent: 3981303 (1976-09-01), Higuchi et al.
patent: 3986510 (1976-10-01), Higuchi et al.
patent: 3995635 (1976-12-01), Higuchi et al.
patent: 4188373 (1980-02-01), Krezanosk
patent: 4217898 (1980-08-01), Theeuwes
patent: 4474452 (1984-10-01), Haslam
patent: 4474751 (1984-10-01), Haslam et al.
patent: 4474752 (1984-10-01), Haslam et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 4853224 (1989-08-01), Wong
patent: 4863457 (1989-09-01), Lee
patent: 4865846 (1989-09-01), Kaufman
patent: 4882150 (1989-11-01), Kaufman
patent: 4892538 (1990-01-01), Aebischer et al.
patent: 5011472 (1991-04-01), Aebischer et al.
patent: 5106627 (1992-04-01), Aebischer et al.
patent: 5221696 (1993-06-01), Ke et al.
patent: 5252714 (1993-10-01), Harris et al.
patent: 5384333 (1995-01-01), Davis et al.
patent: 5422116 (1995-06-01), Yen et al.
Malik et al., "T6F-B Superfamily Members Promote Survival of Midbrain Dopaminergil Neurons and Protect Them Against MPP+ Toxicity", EMBO Journal, vol. 14(4) pp. 736-742 (1995).
"Transplantation of Photoreceptors to Light-Damaged Retina", M. S. Silverman and S. E. Hughes, Investigative Orthalodoxy and Visual Science, vol. 3/8, Aug., pp. 1684-1690 (1989).
LaVail et al., "Multiple Growth Factors, Lytokines, and Neurotrophineresine Photoreceptors from the Damaging Effects of Constant Light", Proc. Natl. Acad. Sci., vol. 89, Dec., pp. 11249-11253 (1992).
Aebischer et al. (1991), `Long-Term Cross-Species Brain Transplantation of a Polymer-Encapsulated Dopamine-Secreting Cell Line`, Exper. Neurol. 111:269-275.
Batchelor et al. (1989), `Nerve Growth Factor Receptor and Choline Acetyltransferase Colocalization in Neurons Within the Rat Forebrain: Response to Fimbria-Fornix Transection`, J. Comp. Neurol. 284:187-204.
Beck et al. (1995), `Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain`, Nature 373:339-341.
Bothwell (1995), `Functional Interactions of Neurotrophins and Neurotrophin Receptors`, Ann. Rev. Neurosci. 18:223-253.
Chamow et al. (1994), `Modification of CD4 Immunoadhesin with Monomethoxypoly (ethylene glycol) Aldehyde via Reductive Alkylation`, Bioconjugate Chem. 5:133-140.
Chao et al. (1995), `p75 and Trk: a two-receptor system`, TINS 18:321-326.
Cunningham and Wells (1989), `High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis`, Science 224:1081-1085.
Dayhoff (1972), Atlas of Protein Sequence and Structure 5:124.
Faktorovich et al. (1990), `Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor`, Nature 347:83-86.
Francis (1992), `Protein modification and fusion proteins`, Focus on Growth Factors 3(2):4-10.
Gouras et al. (1990), `Transplantation of retinal cells`, Neuro-Ophthalmol. 10:165-176.
Gurny, R. et al. (1987), `Design and Evaluation of Controlled Release Systems for the Eye`, Journal of Controlled Release 6:367-373.
Hefti (1994), `Neurotrophic Factor Therapy for Nervous System Degernative Diseases`, J. Neurobiol. 25:1418-1435.
Henderson et al. (1994), `GDNF: A Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle`, Science 266:1062-1064.
Hoffer et al. (1994), `Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo`, Neurosci. Lett. 182:107-111.
Hudson et al. (1995), `Glial Cell Line-derived Neurotrophic Factor Augments Midbrain Dopaminergic Circuits In Vivo`, Brain Res. Bull. 36:425-432.
Kastner et al. (1994), `Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats`, Mol. Brain Res. 26:325-330.
Kiss et al. (1988), `Immunohistochemical Localization of Cells Containing Nerve Growth Factor Receptors in the Different Regions of the Adult Rat Forebrain`, Neurosci. 27:731-748.
Krieglstein et al. (1995), `TGF-.beta. superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP.sup.+ toxicity`, EMBO J. 14:736-742.
Lapchak et al. (1993), `Neurotrophins in the Central Nervous System`, Rev. Neurosci. 3:1-10.
LaVail et al. (1992), `Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light`, Proc. Natl. Acad. Sci. USA 89:11249-11253.
Li and Turner (1988), `Inherited Retinal Dystrophy in the RCS Rat: Prevention of Photoreceptor Degeneration of Pigment Epithelial Cell Transplantation`, Exp. Eye Res. 47:911-917.
Lin et al. (1993), `GDNF: A Glail Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons`, Science 260:1130-1132.
Louis et al. (1992), `Receptor-Mediated Toxicity of Norepinephrine on Cultured Catecholaminergic Neurons of the Rat Brain Stem.sup.1`, J. Pharmacol. Exp. Therap. 262:1274-1283.
Louis et al. (1993), `CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death`, Science 259:689-692.
Malik et al. (1992), `Polyethylene Glycol (PEG)-modified Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) with Conserved Biological Activity`, Exp. Hematol. 20:1028-1035.
Miller et al. (1994), `Central Adminstration of rhGDNF Causes Augmentation of Dopaminergic Activity In Vivo`, Soc. Neurosci. Abstr. 20:1300.
Mullen and La Vail (1976), `Inherited Retinal Dystrophy: Primary Defect in Pigment Epithelium Determined with Experimental Rat Chimeras`, Science 192:799-801.
Olson, Lars (1994), `Neurotrophins in Neurodegenerative Disease: Theoretical Issues and Clinical Trials`, Neurochem. Inc. 25:1-3.
Oppenheim et al. (1995), `Developing motor neurons rescued form programmed and axotomy-induced cell death by GDNF`, Nature 373:344-346.
Poulsen et al. (1994), `TGF.beta.2 and TGF.beta.3 Are Potent Survival Factors for Midbrain Dopaminergic Neurons`, Neuron 13:1245-1252.
Schaar et al. (1994), `Multiple Astrocyte Transcripts Encode Nigral Trophic Factors in Rat and Human`, Exp. Neurol. 130:387-393.
Schaar et al. (1993), `Regional and Cell-Specific Expression of GDNF in Rat Brain`, Exp. Neurol. 124:368-371.
Silverman and Hughes (1989), `Transplantation of Photoreceptors to Light-Damaged Retina`, Invest. Ophthalmol. Vis. Sci. 30:1684-1690.
Spring et al. (1994), `Brief Communication Expression of GDNF mRNA in Rat and Human Nervous Tissue`, Exp. Neurol. 127:167-170.
Stromberg et al. (1993), `Brief Communication Glial Cell Line-Derived Neurotrophic Factor is Expressed in the Developing but not Adult Striatum and Stimulates Developing Dopamine Neurons in Vivo`, Exp. Neurol. 124:401-412.
Thoenen (1991), `The changing scene of neurotrophic factors`, Trends. Neurosci. 14:165-170.
Tomac et al. (1995), `Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo`, Nature 373:335-339.
Tresco et al. (1992), `Polymer Encapsulated Neurotransmitter Secreting Cells`, ASAIO 38:17-23.
Vernero et al. (1993), `TrkA NGF receptor expression by non-cholinergic thalamic neurons`, Neuroreport 4:959-962.
Winn et al. (1991), `Behavioral Recovery following Intrastriatal Implantation of Microencapsulated PC12 Cells`, Exper. Neurol. 113:322-329.
Woolf et al. (1989), `Nerve Growth Factor Receptor is Associated With Cholinergic Neurons of the Basal Forebrain But Not the Pontomesencephalon`, Neuroscience 30:143-152.
Yan and matheson (1995), `In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons`, Nature 373:341-344.
Zurn et al. (1994), `Glial cell-line-derived neurotrophic factor (GDNF), a new neurotrophic fact
Amgen Inc.
Curry Daniel R.
Levy Ron K.
Odre Steven M.
Schain Howard E.
LandOfFree
Methods for treating photoreceptors using glial cell line-derive does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for treating photoreceptors using glial cell line-derive, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treating photoreceptors using glial cell line-derive will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-149157