Methods for treating pain

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4242471, A61K 3908

Patent

active

061139157

ABSTRACT:
Methods for treating pain by intrathecal administration to a human patient of a therapeutically effective amount of a neurotoxin such as botulinum toxin type A are disclosed.

REFERENCES:
patent: 5766605 (1998-06-01), Sanders et al.
Clinical Toxinology Web Site: http://www.wch.sa.gov.au/paedm/clintox/venoms.sub.-- neurotoxins.html., accessed Feb. 24, 2000, Feb. 1998.
Yaksh et al. Chronic Catheterization of the Spinal Subarachnoid Space; Physiology & Behavior, vol. 17, pp. 1031-1036, 1976.
Bigalke, H., et al.; Botulinum A Neurotoxin Inhibits Non-Cholinergic Synaptic Transmission in Mouse Spinal Cord Neurons in Culture; Brain Research, 360 (1985); 318-324.
Bigalke, H., et al.; Tetanus Toxin and Botulinum A. Toxin Inhibit Release and Uptake of Various Transmitters, as Studied with Particulate Preparations from Rat Brain and Spinal Cord; Naunyn-Schmiedeberg's Arch. Pharmacol (1981); 316:244-251.
Dixon, W. J.; Efficient Analysis of Experimental Observations; Ann. Rev. Pharmacol. Toxicol. (1980); 20:441-462.
Dubuisson, D., et al.; The Formalin Test: A Quantitative Study of the Analgesic Effects of Morphine, Meperidine, and Brain Stem Stimulation in Rats and Cats; Pain (1977); 4:161-174.
Duc, C., et al.; Ultrastructural Localization of SNAP-25 Within the Rat Spinal Cord and Peripheral Nervous System; The Journal of Comparative Neurology (1995); 356:152-163.
Habermann, E.; Inhibition by Tetanus and Botulinum A Toxin of the Release of (.sup.3 H)noradrenaline and (.sup.3 H)GABA from Rat Brain Homogenate; Experientia 44 (1988); 224-226.
Habermann, E.; I-Labeled Neurotoxin from Clostridium Botulinum A: Preparation, Binding to Synaptosomes and Ascent to the Spinal Cord; Naunyn Schmiedeberg's Arch. Pharmacol.; 281, 47-56 (1974).
Habermann, E., et al.; Tetanus Toxin and Botulinum A and C Neurotoxins Inhibit Noradrenaline Release from Cultured Mouse Brain; Journal of Neurochemistry; vol. 51; No. 2 (1988); 522-527.
Hagenah, R., et al.; Effects of Type A Botulinum Toxin on the Cholinergic Transmission at Spinal Renshaw Cells and on the Inhibitory Action at Ia Inhibitory Interneurones; Naunyn-Schmiedeberg's Arch. Pharmacol.; 299, 267-272 (1977).
Johnson, E., et al.; Biomedical Aspects of Botulinum Toxin; J. Toxicol.-Toxin Reviews; Feb. 18, 1999; 18(1):1-15.
Jung, H. H., et al.; Expression of Neurotransmitter Genes in Rat Spinal Motoneurons After Chemodenervation with Botulinum Toxin; Neuroscience (1997); vol. 78, No. 2; 469-479.
Kim, S. H., et al.; An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat; Pain, 50 (1992); 355-363.
Mochida, S., et al.; Impairment of Syntaxin by Botulinum Neurotoxin C.sub.1 or Antibodies Inhibits Acetylcholine Release but not Ca.sup.2+ Channel Activity; Neuroscience (1995); vol. 65; No. 3; 905-915.
Nelson, P.G., et al.; Mouse Spinal Cord in Cell Culture. IV. Modulation of Inhibitory Synaptic Function; Journal of Neurophysiology; vol. 40, No. 5; Sep. 1977; 1178-1187.
Osen-Sand, A., et al.; Inhibition of Axonal Growth by SNAP-25 Antisense Oligonucleotides in vitro and in vivo; Nature; July 29, 1993; vol 364; 445-448.
Pearce, L. B., et al.; Pharmacologic Characterization of Botulinum Toxin for Basic Science and Medicine; Toxicon (1997); vol. 35, No. 9; 1373-1412.
Ransom, B.R., et al.; Mouse Spinal Cord in Cell Culture. I. Morphology and Intrinsic Neuronal Electrophysiologic Properties; Journal of Neurophysiology; vol. 40, No. 5; Sep. 1977; 1132-1150.
Ransom, B.R., et al.; Mouse Spinal Cord in Cell Culture. II. Synaptic Activity and Circuit Behavior; Journal of Neurophysiology; vol. 40, No. 5; Sep. 1977; 1151-1162.
Ransom, B.R., et al.; Mouse Spinal Cord in Cell Culture. III. Neuronal Chemosensitivity and its Relationship to Synaptic Activity; Journal of Neurophysiology; vol. 40, No. 5; Sep. 1977; 1163-1177.
Sanchez-Prieto, J., et al.; Botulinum Toxin A Blocks Glutamate Exocytosis from Guinea-Pig Cerebral Cortical Synaptosomes; Eur. J. Biochem. (1987); 165:675-681.
Simpson, L.; Botulinum Toxin: Potent Poison, Potent Medicine; Hospital Practice; Apr. 15, 1999; 34(4):87-91.
Tsuda, M., et al.; In vivo Pathway of Thermal Hyperalgesia by Intrathecal Administration of .alpha.,.beta.-methylene ATP in Mouse Spinal Cord: Involvement of the Glutamate-NMDA Receptor System; Br. J. Pharmacol (1999); 127(2):449-456.
Wiegand, H., et al.; The Action of Botulinum A Neurotoxin on the Inhibition by Antidromic Stimulation of the Lumbar Monosynaptic Reflex; Naunyn-Schmiedeberg's Arch. Pharmacol. (1977); 298:235-238.
Williamson, L. C., et al.; Clostridial Neurotoxins and Substrate Proteolysis in Intact Neurons; The Journal of Biological Chemistry; Mar. 29, 1996; vol. 271:13; 7694-7699.
Williamson, L. C., et al.; Differential Effects of Tetanus Toxin on Inhibitory and Excitatory Neurotransmitter Release from Mammalian Spinal Cord Cells in Culture; Journal of Neurochemistry; 1992; vol. 59:6; 2148-2157.
Woolf, C. J., et al.; Neuropathic Pain: Aetiology, Symptoms, Mechanisms, and Management; The Lancet; Jun. 5, 1999; vol. 353; 1959-1964.
Yaksh, T. L., et al.; Chronic Catheterization of the Spinal Subarachnoid Space; Physiology & Behavior (1976); vol. 17:1031-1036.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for treating pain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for treating pain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treating pain will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2209274

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.