Methods for treating inflammatory bowel disease with leukotriene

Details Methods for treating inflammatory bowel disease with leukotriene Methods for treating inflammatory bowel disease with leukotriene

1993-02-26

1995-02-21

Henley, III, Raymond J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514312, 514314, 514925, A61K 3147

Patent

active

053915550

ABSTRACT:
Described are methods for ameliorating symptoms associated with inflammatory bowel disease such as ulcerative colitis and Crohn's disease (regional enteritis) with four specific quinoline leukotriene synthesis inhibitors.

REFERENCES:
patent: 4970215 (1990-11-01), Mohs et al.
patent: 5091392 (1992-11-01), Raddatz et al.
Rask-Madsen et al., "5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease," Agents Action, Special Conference Issue, pp. C37-C46 (1992).
Wallace and Keenan, "An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis," Leukotriene Inhibition in Experimental Colitis, pp. G527-G534 (1990).
Staerk Laursen et al., "Selective 5-lipoxygenase inhibition in ulcerative colitis," Lancet 335, pp. 683-685 (1990).
Okayasu et al., "A Novel Method in the Induction of Reliable Experimental Acute and Chronic Ulcerative Colitis in Mice," Gastroenterology 98, pp. 694-702 (Mar. 1990).

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