Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-05-13
1999-06-01
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514309, 514617, 514619, 514622, 514825, 514898, A61K 3147, A61K 3135, A61K 31165
Patent
active
059088613
ABSTRACT:
The present invention is directed to a method for treating inflammation or inflammatory disease in an animal or mammal, which comprises the steps of administering an effective amount of an pADPRT inhibitory compound to said animal or mammal.
REFERENCES:
patent: 5262564 (1993-11-01), Kun et al.
patent: 5464871 (1995-11-01), Kun et al.
patent: 5473074 (1995-12-01), Kun et al.
patent: 5482975 (1996-01-01), Kun et al.
patent: 5484951 (1996-01-01), Kun et al.
patent: 5516941 (1996-05-01), Kun et al.
patent: 5583155 (1996-12-01), Kun et al.
CA 116:262534, Clemens et al., Mar. 1992.
CA 113:40476, Friary, Jan. 1990.
Anderson, et al., "Selective Inhibition of Cyclooxygenase (COX)-2 Reverses Inflammation and Expression of COX-2 and Interleukin 6 in Rat Adiuvant Arthritis." J. Clin. Invest.--97(11):2672-2679 (1996).
Baeuerle, et al., "Function and Activation of NF-.sub.k B in the Immune System," Ann. Rev. Immunol.--12:141-179 (1994).
Bauer, et al., "Modification of Growth Related Enzymatic Pathways and Apparent Loss of Tumorigenicity of a ras-Transformed Bovine Endothelial Cell Line by Treatement with 5-Iodo-6-Amino-1,2-Benzopyrone (INH.sub.2 BP)," Int. J. Oncol.--8:239-252 (1996).
Berger, "Oxidant-Induced Cytotoxicity: A Challenge for Metabolic Modulation," Am. J. Respir. Cell Mol. Biol.--4:1-3 (1991).
Beutler, "TNF, Immunity and Inflammatory Disease: Lessons of the Past Decade," J. Investigative Medicine--43(3): 227-235 (1995).
Brahn, et al., Animal Models of Rheumatoid Arthritis, Clin. Orthop. Rel. Res.--265:52-53 (1991).
Buki, et al., "Identification of Domains of Poly(ADP-Ribose) Polymerase for Protein Binding and Self-Association, " J. Biol. Chem.--270(7):337-3377 (1995).
Cochrane, et al., "Mechanisms of Oxidant Injury of Cells," Molec. Aspects Med.--12:137-147 (1991).
Conner, et al., "Suppression of Adjuvant-Induced Arthritis by Selective Inhibition of Inducible Nitric Oxide Synthase," Eur. J. Pharmacol.--273:15-24 (1995).
Cowley, et al., "Activation of MAP Kinase Kinase is Necessary and Sufficient for PC12 Differentiation and for Transformation of NIH 3T3 Cells," Cell--77:841-852 (1994).
Crow, et al., "The Role of Peroxynitrite in Nitric Oxide-Mediated Toxicity," Current Top Microbiol. Immunol.--196:57-73 (1995).
Farrell, et al., "Increased Concentration of Nitrite in Synovial Fluid and Serum Samples Suggest Increased Nitric Oxide Synthesis in Rheumatic Diseases," Ann. Rhem Dis.--51:1219-1222 (1992).
Ferrell, "Tripping the Switch Fantastic: How a Protein Kinase Cascade Convert Graded Inputs Into Switch-Like Outputs," TIBS--21:460-466 (1996).
Giroir, et al., "Mediators of Septic Shock: New Approaches for Interrupting the Endogenous Inflammatory Cascade," Critical Car. Med.--21(5):780-789 (1993).
Grabowski, et al., "Nitric Oxide Production in Cells Derived from the Human Joint," Br. J. Rheumatol.--35:207-212 (1996).
Griffin, et al., "The in vitro Effect of Benzamide and Phenobarbital on Liver Enzymes: Poly(ADP-Ribose) Polymerase, Cytochrome P-450, Styrene Oxide Hydrolase, Glutathione S-transferase and UDP-Glucuronyl Transferase," Biochem. Biophys. Res. Comm.--122(2):770-775 (1984).
Hauschildt, et al., "Induction of Nitric oxide Synthase in L929 Cells by Tumour-Necrosis Factor .alpha. is Prevented by Inhibitors of Poly(ADP-Ribose) Polymerase," Biochem. J.--288:255-260 (1992).
Hauselmann, et al., "Nitric Oxide and Proteoglycan Biosynthesis by Human Articular Chondrocytes in Alginate Culture," FEBS Lett.--352:361-364 (1994).
Kaur, et al., "Evidence for Nitric Oxide-Medicated oxidative Damage in Chronic Inflammation--Nitrotyrosine in Serum and Synovial Fluid from Rheumatoid Patients," FEBS Lett.--350:9-12 (1994).
Kawai, et al., "Enhancement of Rat Urinary Bladder Tumorigenesis by Lipopolysaccharide-Induced Inflammation," Cancer Res.--53:5172-5175 (1993).
Kyriakis, et al., "Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation," J. Biol. Chem.--271(40):24313-24316 (1996).
L'Allemain, "Deciphering the Map Kinase Pathway," Prog. Growth Factor Res.--5:291-334 (1994).
Levitzki, et al., "Signal-Transduction Therapy--A Novel Approach to Disease Management," Eur. J. Biochem.--226:1-13 (1994).
Liles, et al., "Review: Nomenclature and Biologic Significance of Cytokines Involved in Inflammation and the Host Immune Response," J. Infect Dis.--172:1573-1580 (1995).
Lindahl, et al., "Post-Translational Modification of Poly(ADP-Ribose) Polymerase Induced by DNA Strand Breaks," Trends Biochem. Sci.--20:405-411 (1995).
Liu, et al., "Woodchuck Hepatitis Virus Surface Antigen Induces Nitric Oxide Synthesis in Hepatocytes: Possible Role in Hepatocarcinogenesis," Carcinogenesis--15(12):2875-2877 (1994).
Lowenstein, et al., "Macrophase Nitric Oxide Synthase Gene: Two Upstream Regions Mediate Induction by Interferon .gamma. and Lipopolysaccharide," Proc. Natl. Acad. Sci.--90:9730-9734 (1993).
Marczin, et al., "Tyrosine Kinase Inhibitors Suppress Endotoxin--and IL-1.beta.-Induced NO Synthesis in Aortic Smooth Muscle Cells," Am. J. Physiol.--265:H1014-1018 (1993).
Martin, et al., "Role of Interferon Regulatory Factor 1 in Induction of Nitric Oxide Synthase," J. Exp. Med.--180:977-984 (1994).
Matsuda, et al., "Signaling Pathways Mediated by the Mitogen-Activated Protein (MAP) Kinase Kinase/MAP Kinase Cascade," J. Leukocyte Biology--56:548-553 (1994).
McCartney-Francis, et al., "Suppression of Arthritis by an Inhibitor of Nitric Oxide Synthase," J. Exp. Med.--178:749-754 (1993).
Miesel, et al., "Effects of Allopurinol on in vivo Suppression of Arthritis in Mice and ex vivo Modulation of Phagocytic Production of Oxygen Radicals in Whole Human Blood," Inflammation--18(6):597-612 (1994).
Muller, et al., "Nuclear Factor Kappa .beta., a Mediator of Lipopolysaccharide Effects," Immunobiol.--187:233-256 (1993).
Murrell, et al., "Nitric Oxide: An Important Articular Free Radical," J. bone Joint Sur.-Am.--78:265-274 (1996).
Nathan, "Nitric Oxide as a Secretory Product of Mammalian Cells," FASEB J.--6:3051-3064 (1992).
Novogrodsky, et al., "Prevention of Lipopolysaccharide-Induced Lethal Toxicity by Tyrosine Kinase Inhibitors," Science--264:1319-1322 (1994).
Ohshima, et al., "Chronic Infections and Inflammatory Processes as Cancer Risk Factors: Possible Role of Nitric Oxide in Carcinogenesis," Mutation Res.--305:253-264 (1994).
Oyanagui, "Nitric Oxide and Superoxide Radical are Involved in Both Initiation and Development of Adjuvant Arthritis in Rats," Life Sci.--54(17):PL285-L289 (1994).
Pang, et al., "Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor," J. Biol. Chem.--270(23):13585-13588 (1995).
Pellat-Deceunynck, et al., "Nicotinamide Inhibits Nitric Oxide Synthase mRNA Induction in Activated Macrophages," Biochem. J.--297:53-58 (1994).
Pryor, et al., "The Chemistry of Peroxynitrite: A Product from the Reaction of Nitric Oxide with Superoxide," Am. J. Physiol.--L699-L772 (1995).
Rosin, et al., "Inflammation, Chromosomal Instability, and Cancer: The Schistosomiasis Model," Cancer Res.--54:1929s-1933s (1994).
Saklatvala, et al., "Interleukin 1 and Tumour Necrosis Factor Activate the Mitogen-Activated Protein (MAP) Kinase Kinase in Cultured Cells," FEBS--334(2):189-192 (1993).
Sakurai, et al., "Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression in Inflammatory Arthritides," J. Clin. Invest.--96:2357-2363 (1995).
Singh, et al., "Regulation of Cytokine-Inducible Nitric Oxide Synthase in Cardiac Myocytes and Microvascular Endothelial Cells," J. Biol. Chem.--271(2):1111-1117 (1996).
Southan, et al., "Spontaneous Rearrangement of Aminoalkylisothioureas into Mercaptoalkylguanidines, a Novel Class of Nitric Oxide Synthase Inhibitors with Selectivity Towards the Inducible Isoform," Br. J. Pharmacol.--(1996).
Stefanovic-Racic, et al., "Nitric Oxide and Arthritis," Arthr. Rhemat.--36(8):1036-1044 (1993).
Stefanovic-Racic, et al., "N-Monomethyl Arginine, an Inhibitor of Nitric oxide Synthase, Suppresses the Development of Adjuvant Arthritis in Rats," Arthr. Rhemat.--37:1062-1069 (1994).
Stichtenoth, et al., "Urinary Nitrate Excretio
Halluin Albert P.
Jordan Kimberly
Octamer, Inc.
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