Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-11-04
2000-05-02
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3144
Patent
active
060573449
ABSTRACT:
Methods are disclosed utilizing the optically pure (-) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (-) isomer of amlodipine is also useful for the treatment of angina without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.
REFERENCES:
patent: 4572909 (1986-02-01), Campbell et al.
patent: 4806557 (1989-02-01), Campbell et al.
patent: 4879303 (1989-11-01), Davison et al.
Goldmann, S. et al., "Determination of the Absolute Configuration of the Active Amlodipine Enantiomer as (-)-S: A Correction", Journal of Medicinal Chemistry 35(18):3341-3344 (1992).
Alker, D. et al., "Long-acting dihydropyridine calcium antagonists. 9. Structure Activity Relationships Around Amlodipine", Eur. J. Med. Chem. 26: 907-913 (1991).
Basco, L.K. and Le Bras, J., "Plasmodium falciparum: In Vitro Drug Interaction between Chloroquine and Enantiomers of Amlodipine", Experimental Parasitology 72: 262-270 (1991).
Deloron, P. et al., "In Vitro and In Vivo Potentiation of Chloroquine against Malaria Parasites by an Enantiomer of Amlodipine", Antimicrobial Agents and Chemotherapy 35(7): 1338-1342 (1991).
Eriksson, U.G. et al., "Stereoselective Metabolism of Felodipine in Liver Microsomes from Rat, Dog, and Human", Drug Metabolism and Disposition 19(5): 889-894 (1991).
Goldmann, S. and Stoltefuss, J., "1,4-Dihydroyridines: Effects of Chirality and Conformation on the Calcium Antagonist and Calcium Agonist Activities", Angew. Chem. Int. Ed. Engl. 30: 1559-1578 (1991).
Nayler, W.G. and Gu, X.H., "(-)[.sup.3 H]Amlodipine Binding to Rat Cardiac Membranes", Journal of Cardiovascular Pharmacology 17: 587-592 (1991).
Okamoto, Y. et al., "Optical resolution of dihydropyridine enantiomers by high-performance liquid chromatography using phenylcarbamates of polysaccharides as chiral stationary phase", Journal of Chromatography 513: 375-378 (1990).
Soons, P.A. et al., "Enantioselective Determination of Felodipine and Other Chiral Dihydropyridine Calcium Entry Blockers in Human Plasma", Journal of Chromatography 528: 343-356 (1990).
Abernethy, D.R., "The Pharmacokinetic Profile of Amlodipine", American Heart Journal 1100-1103 (1989).
Burges, R.A. et al., "Pharmacologic Profile of Amlodipine", The American Journal of Cardiology 64: 10-20 (1989).
Glasser, S.P. et al., "Safety and Efficacy of Amlodipine Added to Hydrochlorothiazide Therapy in Essential Hypertension", American Journal of Hypertension, Inc. 2(3)(1): 154-157 (1989).
The Merck Index, Eleventh Edition, Monograph 509 (1989).
Osterloh, I., "The safety of amlodipine", American Heart Journal 1114-1120 (1989).
Isenrign, H.P., "Antifungal Morpholine Derivatives: Chemistry and Structure-Activity Relationships", Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents, R.A. Fromtling (Ed.), J.R. Prous Science Publishers, S.A., pp. 543-554 (1987).
Arrowsmith, J.E. et al., "Long-Acting Dihydropyridine Calcium Antagonists. 1. 2-Alkoxymethyl Derivatives Incorporating Basic Substituents", J. Med. Chem. 29: 1696-1702 (1986).
A.R. Gennaro, Ed., "Remington's Pharmaceutical Sciences, 18th Ed." published by Mack Publishing Co. (Easton, PA), pp. 853-854 (1990).
Ariens, E.J., "Stereoselectivity in Pharmacodynamics and Pharmacokinetics", Schweiz. Med. Wochenschr. 120: 131-134 (1990).
Ariens, E.J., "Racemic Therapeutics--Ethical and Regulatory Aspects", Eur. J. Clin. Pharmacol. 41:89-93 (1991).
J. Luksa et al., "Pharmacokinetic Behaviour of R-(+)-and S-(-)-Amlodipine After Single Enantiomer Administration," Journal of Chromatography B, 703:185-193 (1997).
H. Laufen et al., "Enantioselective Disposition of Oral Amlodipine in Healthy Volunteers," Chirality, 6:531-536 (1994).
Jarvis William R. A.
Sepracor Inc.
LandOfFree
Methods for treating hypertension, and angina using optically pu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for treating hypertension, and angina using optically pu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treating hypertension, and angina using optically pu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1594171