Methods for treating human proliferative diseases, with a...

Details Methods for treating human proliferative diseases, with a... Methods for treating human proliferative diseases, with a...

2005-04-28

2008-11-04

Rao, Manjunath (Department: 1647)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C424S146100, C424S130100, C424S138100, C424S141100, C514S027000, C514S043000, C514S079000

Reexamination Certificate

active

07445794

ABSTRACT:
The present invention generally relates to systems and methods for treating inflammatory and proliferative diseases, and wounds, using a combination of (1) fatty acid metabolism inhibitors and (2) glycolytic inhibitors and/or UCP and/or Fas inhibitors or antibodies. More particularly, the invention combines an oxirane carboxylic acid compound, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and/or an antibody against UCP and/or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers (i.e., cancers resistant to conventional cancer drug therapies).

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