Methods for treating HIV infected subjects

Details Methods for treating HIV infected subjects Methods for treating HIV infected subjects

2007-06-19

2007-06-19

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C424S093100, C424S093700, C424S534000, C424S577000, C424S578000, C435S002000, C435S375000, C435S377000

Reexamination Certificate

active

11029188

ABSTRACT:
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

REFERENCES:
patent: 4654210 (1987-03-01), Kung et al.
patent: 5004681 (1991-04-01), Boyse et al.
patent: 5081029 (1992-01-01), Zarling et al.
patent: 5500348 (1996-03-01), Nishimura et al.
patent: 5521288 (1996-05-01), Linsley et al.
patent: 5601819 (1997-02-01), Wong et al.
patent: 5696079 (1997-12-01), Lane et al.
patent: 5858358 (1999-01-01), June et al.
patent: 5872222 (1999-02-01), Chang
patent: 5883223 (1999-03-01), Gray
patent: 6010902 (2000-01-01), Ledbetter et al.
patent: 6129916 (2000-10-01), Chang et al.
patent: 6352694 (2002-03-01), June et al.
patent: 6534055 (2003-03-01), June et al.
patent: 6797514 (2004-09-01), Berenson et al.
patent: 6887466 (2005-05-01), June et al.
patent: 6905680 (2005-06-01), June et al.
patent: 6905681 (2005-06-01), June et al.
patent: 2002/0076407 (2002-06-01), June et al.
patent: 2004/0001829 (2004-01-01), June et al.
patent: 2006/0013832 (2006-01-01), June et al.
patent: 0 360 205 (1990-03-01), None
patent: 0 440 373 (1991-08-01), None
patent: 0440373 (1991-08-01), None
patent: 0 448 057 (1991-09-01), None
patent: 0440376 (1992-04-01), None
patent: 02-502424 (1990-08-01), None
patent: 04-502009 (1992-04-01), None
patent: WO88/07077 (1988-09-01), None
patent: WO-90/05541 (1990-05-01), None
patent: WO90/05541 (1990-05-01), None
patent: WO 90/05541 (1990-05-01), None
patent: WO 92/00092 (1992-01-01), None
patent: WO-92/00092 (1992-01-01), None
patent: WO 93/19767 (1993-10-01), None
patent: WO 94/12196 (1994-06-01), None
patent: WO 94/29436 (1994-12-01), None
patent: WO 95/33823 (1995-12-01), None
Asjo et al., “A Novel Mode of Human Immunodeficiency Virus Type 1 (HIV-1) Activation: Ligation of CD28 Alone induce HIV-1 Replication in Naturally Infected Lymphocytes” Journal of Virology, 1993, vol. 67, No. 7, pp. 4395-4398.
Azuma et al., “Functional Expression of B7/BB1 on Activated T Lymphocytes” J. of Exp. Med., vol. 177. pp. 845-850 (1993).
Baroja et al., “Cooperation Between an Anti-T Cell (Anti CD28) Monoclonal Antibody and Monocyte-produced IL-6 in the Induction of T Cell Responsiveness to IL-2” The Journal of Immunology, vol. 141, No. 5, pp. 1502-1507 (1988).
Baroja et al., “The Anti-T Cell Monoclonal Antibody 9.3 (Anti-CD28) Provides and Helper Signal and Bypasses the Need for Accessory Cells in T Cell Activation wtith Immobilized Anti CD3 and Mitogens,” Cellular Immunology, vol. 120, pp. 205-217 (1989).
Boucheix, C. et al., “Molecular Cloning of the CD9 Antigen,” The Journal of Biological Chemistry, vol. 266, No. 1, pp. 117-122 (1991).
Carroll et al., “Stimulus-response Coupling in Human Platelets Activated by Monoclonal Antibodies to the CD9 Antigen, a 24 kDa Surface Membrane Glycoprotein,” Biochem. J., vol. 266, pp. 527-535 (1990).
Chow et al. Nature, vol. 361, pp. 650-654 (1993).
Damle et al. “Differential Regulatory Signals Delivered by Antibody binding to the CD28 (Tp44) Molecule During the Activation of Human T Lymphocytes” Journals of Immunology, vol. 140, No. 6, pp. 1753-1761 (1988).
Damle and Doyle, “Stimulation Via the CD3 and CD28 Molecules Induces Responsiveness to IL-4 in CD4+CD29+CD45R-Memory T Lymphocytes” Journal of Immunology, vol. 143, No. 6, pp. 1761-1767 (1989).
Diegel et al., “Regulation of HIV Production by Blood Mononuclear Cells from HIV-infected Donors: II. HIV-1 Production Depends on T-Cell-Monocyte Interaction,” AIDS Research and Human Retroviruses. vol. 9, No. 5, pp. 465-473 (1993).
Fahey et al. Clin. Exp. Immunol. vol. 88, pp. 1-5 (1992).
Galvin et al. “Murin B7 Antigen Provides a Sufficient Costimulatory Signal for Antigen-Specific and MHC-Restricted T Cell Activation” Journal of Immunology, vol. 149, No. 12, pp. 3802-3808 (1992).
Garbrecht, et al. J. Immunol. Methods. vol. 107, pp. 137-142 (1988).
Geppert and Lipsky, “Accessory Cell Independent Proliferation of Human T4 Cells Stimulated by Immobilized Monoclonal Antibodies to CD3,” The Journal of Immunology, vol. 138, No. 6, pp. 1660-1666 (1987).
Groux et al., “Activation-induced Death by Apoptosis in CD4+ T Cells from Human Immunodeficiency Virus-Infected Asymptomatic Individuals,” J. Exp. Med., vol. 175, pp. 331-340 (1992).
Guinan et al. Blood, vol. 84,pp. 3261-3282 (1994).
Hansen et al. “Monoclonal Antibodies Identifying a Nove T-Cell Antigen and Ia Antigens of Human Lymphocytes” Immunogenetics, vol. 10, pp. 247-260 (1980).
Hara et al., “Human T Cell Activation” J. Exp. Med., vol. 161, pp. 1513-1524 (1985).
Harding et al., “CD28-mediated signalling co-stimulates murine T cells and prevents induction of energy in T-cell clones” Nature, vol. 356, pp. 607-609 (1992).
Haynes, Ann. Med. vol. 28, pp. 39-41 (1996).
Hirsch, New England J. Med., vol. 328, pp. 1686-1695 (1993).
Jong et al. “Regulation of T-Cell Differentiation by CD2 and CD28 Accessory Molecules” Immunology, vol. 74, pp. 175-182 (1991).
June et al. “Evidence for the Involvement of Three Distinct Signals in the Induction of IL-2 Gene Expression in Human T Lymphocytes” Journal of Immunology, vol. 143, No. 1, pp. 153-161 (1989).
June et al. “Role of the CD28 Receptor in T-Cell Activation” Immunology Today, vol. 11, No. 6, pp. 211-216 (1990).
June et al. “T-Cell Proliferation Involving the CD28 Pathway is Associated with Cyclosporine-Resistant Interleukin 2 Gene Expression” Molecular and Cellular Biology, vol. 7, No. 12, pp. 4472-4481 (1987).
Kalinski et al., “Functional Maturation of Human Naïve T Helper Cells in the Absence of Accessory Cells,” The Journal of Immunology, vol. 154, pp. 3753-3760 (1995).
King et al., “CD28 Activation Promotes Th2 Subset Differentiation by Human CD4+ Cells,” Eur. J. Immunol., vol. 25, pp. 587-595 (1995).
Kmiec. American Scientist. vol. 87, pp. 240-247 (1999).
Koulova et al. “Identification of the Anti-CD3-Unresponsive Subpopulation of CD4+, CD45RA+ Peripheral T Lymphocytes” Journal of Immunology, vol. 145, No. 7, oo. 2035-2043 (1990).
Lanza et al., “cDNA Cloning and Expression of Platelet p24/CD9” Journal of Biological Chemsitry, vol. 266, No. 16, pp. 10638-10645 (1991).
Ledbetter et al., “Antibodies to Tp67 and Tp44 Augment and Sustain Proliferative Response of Activated T Cells” Journal of Immunology, bol. 135, No. 4, pp. 2231-2236 (1985).
Ledbetter et al., “Antibody Binding to CD5 (Tp67) and Tp44 T Cell Surface Molecules; Effects on Cyclic Nucleotides, Cytoplasmic Free Calcium, and cAMP-Mediated Suppression” Journal of Immunology, vol. 137, No. 10, pp. 3299-3305 (1986).
Ledbetter et al., PNAS, vol. 85, pp. 8628-8632 (1988).
Ledbetter et al. “CD28 Ligation in T-Cell Activation: Evidence for Two Signal Transduction Pathways” Blood, vol. 75, No. 7, pp. 1531-1539 (1990).
Ledbetter et al., “Crosslinking of Surface Antigens Causes Ionized Calcium in T Lymphocytes” Proceedings of the National Academy of Sciences, vol. 84, pp. 1384-1388 (1987).
Ledbetter et al. “Role of CD2 cross-linking in cytoplasmic calcium responses and T Cell activation” Eur. J. Immunol., vol. 18, pp. 1601-1608 (1988).
Lederman et al.,

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