Drug – bio-affecting and body treating compositions – Dentifrices – Ammonia – amine – or derivative thereof
Patent
1987-01-27
1989-11-07
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Dentifrices
Ammonia, amine, or derivative thereof
424 58, 4241951, 424640, 424641, 514900, 514901, 514902, A61K 722, A61K 726, A61K 3324, A61K 3330
Patent
active
048791067
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a composition for preparing a medicament for topical treatment of paradentium diseases. More particularly, the present invention relates to a pharmaceutical composition which is already known per se, and which has shown an unforeseeable and efficient activity in the medical treatment of diseases of the oral mucous membranes, especially in the treatment of gingivitis and alveolar pyorrhea.
As is well known, gingivitis is a general term comprising the inflammations of gums resulting from various causes, for instance from toxic, bacterial causes, from dyscrasia, from avitaminosis etc., which are supported and promoted by salivary tartar or by other constitutional factors.
The inflammatory or swollen state is generally concomitant with a high tendency to bleeding, which results from even very low traumatic causes, such as those due to the commonly performed hygienic care of the oral cavity.
The treatments which are generally recommended for gingivitis consist in the employment of special toothpastes, of mouth-washes or of liquid solutions for gums to be applied locally. None of the known products showed suitable to give a rapid and definitive solution to the problem of such diseases of paradentium, as they allow to obtain at most a temporary relief from the swollen or inflammatory state and from bleeding, and, in addition, repeated and constant applications of such products are necessary in most cases.
As is likewise already known, pyorrhea is a degenerative and inflammatory disease affecting teeth and paradentium, aetiology of such disease being not well known. Among the factors which originate the disease, a major importance seems to be ascribable to debilitating diseases, avitaminoses, metabolic and endocrine alterations.
According to the prevalence of the degenerative or of inflammatory phenomena, a purulent inflammatory and a necrotic-degenerative are distinguished. The first one is characterized by chronic putrefaction phenomena affecting the gums, the peridental tissues and the alveolar walls with the formation of pyorrhoic pockets or cavities from which a purulent material comes out. The gums show a tendency to become loose and teeth become increasingly unsteady till they are lost.
In the ischemic and degenerative form, which is called "dry pyorrhea", no alterations affect the gums, but an always increasing unsteadiness occurs of teeth till they are lost.
The medical treatment employed up to the present time consists in treating the general diseases possibly present, and in caring for a scrupulous hygiene of the mouth. Sometimes suitable prostheses are employed for keeping the teeth steady by linking the same to each other, or teeth are devitalized so as to cause the arthrosis of the dental alveolar articulation.
As a consequence, though some preparations are commercially available at the present time which are recommended as coadjuvant agents in the therapy of pyorrhea, no drugs exist which are able to cure such disease, and alveolar pyorrhea is considered as in incurable affection which very often makes it necessary to replace teeth by a dental prosthesis.
Thus, the object of the present invention is to provide a composition suitable to be employed for obtaining a medicament for treatment of pyorrhea, gingivitis, and in general of any affection of paradentium.
After different and ineffectual attempts, it was surprisingly discovered that a composition comprising the ammonium salt of sulfoichthyolic acid, zinc oxide and titanium dioxide, the fluid extract of Hamamelis and a pharmaceutically acceptable carrier caused a remarkably rapid and complete recovery of patients affected with various forms of paradentium diseases.
A composition of the kind mentioned above was already known but it has never been applied to the medical topical treatment of the affections of the oral mucous membrane, and it is to be remarked that the surprising specific efficiency of said composition, clearly observed and specified within the scope of the present invention, was really unforeseeable.
REFERENCES:
patent: 4425325 (1984-01-01), Ritchey et al.
Martindale--The Extra Pharmacopoeia, The Pharmaceutical Press, Twenty-eighth Edition (1982) pp. 286, 496, 509, 510.
Bushnell Richard
Lipovsky Joseph A.
Robinson Douglas W.
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