Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-07-28
1982-11-16
Rosen, Sam
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424250, 424258, 424267, 424270, 424273R, 424273B, A61K 3144
Patent
active
043594654
ABSTRACT:
The present invention relates to the novel cytoprotective use for known heterocyclyalkylsulfinylbenzimidazoles, and novel, substantially non-antisecretory unit dose pharmaceutical compositions thereof.
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patent: 4045563 (1977-08-01), Berntsson et al.
patent: 4073998 (1978-04-01), Robert
patent: 4081553 (1978-03-01), Robert
patent: 4097603 (1978-06-01), Robert
C. Johansson, et al., "Mucosal Protection by Prostaglandin E.sub.2 ", The Lancet, Feb. 2, 1979, p. 317.
M. M. Cohen, "Mucosal Cytoprotection by Prostaglandin E.sub.2 ", The Lancet, Dec. 9, 1978, pp. 1253-1254.
Robert, A., "Cytoprotection Against Acidified Aspirin: Comparison of Prostaglandin, Cimetidine, and Probanthine", Gastroenterology 76: 1227 (May 1979).
Kauffman, G. L., et al., "Cimetidine Does Not Inhibit Indomethacin-Induced Small Bowel Ulceration in the Rat", Proc. of the Exp. Biol. Med. 161: 512-4 (1979).
Robert, A., "Method of Treatment and Prophylaxis of Gastric Hypersection and Gastric Duodenal Ulcers Using Prostaglandin Analogs", Prostaglandin Symposium of the Worcester Foundation for Experimental Biology, Oct. 16-17, 1967, Inter-Science, New York, 1978, p. 47.
Lars Olbe, et al., "Properties of a New Class of Gastric Acid Inhibitors", Scand. J. Gastroenterol., 14: 131-135 (1979, Supp 55).
Merck Index, 9th Edition, (APP-1 A-3).
Physicians' Desk Reference, 34th Edition (1980), pp. 1636-1641.
Hattan L. R.
Rosen Sam
The Upjohn Company
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