Methods for treating cancers and pathogen infections using antig

Details Methods for treating cancers and pathogen infections using antig Methods for treating cancers and pathogen infections using antig

1996-04-30

1998-12-29

Degen, Nancy

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435 721, 435 723, 435 724, 435 693, A01N 6300

Patent

active

058537198

ABSTRACT:
Disclosed are cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells (e.g., dendritic cells or macrophage) that have been loaded with RNA derived from tumors or pathogens. By administering the RNA-loaded antigen-presenting cells to a patient, tumor formation or pathogen infections can be treated or prevented. Alternatively, the RNA-loaded cells can be used as stimulator cells in the ex vivo expansion of CTL. Such CTL can then be used in a variation of conventional adoptive immunotherapy techniques.

REFERENCES:
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Vanden Bosch, et al. 1986. I+I 53(3): 611-615. "T-Cell-Independent Macrophage Activation in Mize Induced with rRNA from Listeria...".
Kim et al, "Interleukin-secreting Mouse Fibroblasts Transfected with Genomic DNA from Murine Melanoma Cells Prolong the Survival of Mice with Melanoma", Cancer Research 54:2531-2535 (1994).
Bhoopalam et al, "Surface Immunoglobulins of Circulating Lymphocytes in Mouse Plasmacytoma. II. The Influence of Plasmacytoma RNA Surface Immunoglobulins of Lymphocytes", Blood 39(4):465-471 (1972).
Villarreal et al, "Common Mechanisms of Transformation by Small DNA Tumor Viruses", Washington, D.C.: American Society of Microbiology, Chapter 1, pps. 1-17 (1989).

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