Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-09-05
2006-09-05
Wilson, Michael C. (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Reexamination Certificate
active
07101705
ABSTRACT:
Disclosed are cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells (e.g., dendritic cells or macrophage) that have been loaded with RNA derived from tumors or pathogens. By administering the RNA-loaded antigen-presenting cells to a patient, tumor formation or pathogen infections can be treated or prevented. Alternatively, the RNA-loaded cells can be used as stimulator cells in the ex vivo expansion of CTL. Such CTL can then be used in a variation of conventional adoptive immunotherapy techniques.
REFERENCES:
patent: 4918164 (1990-04-01), Hellstrom et al.
patent: 5256536 (1993-10-01), Miyada et al.
patent: 5662907 (1997-09-01), Kubo et al.
patent: 5827642 (1998-10-01), Riddell et al.
patent: 5830877 (1998-11-01), Carson et al.
patent: 5831068 (1998-11-01), Nair et al.
patent: 5853719 (1998-12-01), Nair et al.
patent: 6130087 (2000-10-01), Srivastava et al.
patent: 6306388 (2001-10-01), Nair et al.
patent: 6387701 (2002-05-01), Nair et al.
patent: 6670186 (2003-12-01), Nair et al.
patent: WO 94/04171 (1994-03-01), None
patent: WO 94/04557 (1994-03-01), None
patent: WO 97/41210 (1997-11-01), None
Kim et al, “Interleukin-secreting Mouse Fibroblasts Transfected with Genomic DNA from Murine Melanoma Cells Prolong the Survival of Mice with Metanoma”, Cancer Research 54:2531-2535 (1994).
Bhoopalam et al, “Surface Immunoglobulins of Circulating Lymphocytes in Mouse Plasmacytoma. II. The Influence of Plasmacytoma RNA on Surface Immunoglobins of Lymphocytes”, Blood 39(4):465-471 (1972).
Villarreal et al, “Common Mechanisms of Transformation by Small DNA Tumor Viruses”, Washington, D.C.: American Society of Microbiology, Chapter 1, pp. 1-17 (1989).
Inada et al, “Comparison of the Ability of Lactate-Dehydrogenase Elevating Virus and Its Viron . . . ”, J. Virol. 67(9):5698-5703 (1993).
van den Bosch et al, “T-Cell-Independent Macrophage Activation in Mice Induced with rRNA from Listeria . . . ”, Infec. & Immun. 53(3):611-615 (1986).
Celluzzi et al, “Peptide-pulsed Dendritic Cells Induce Antigen-specific, CTL-mediated Protective Tumor Immunity”, J. Exp. Med. 183:283-287 (1996).
Nair et al, “Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines”, Eur. J. Immunol. 27:589-597 (1997).
Kormanec and Farkasovsky, “Isolation of Total RNA from Yeast and Bacteria and Detection of rRNA in Northern Blots”, Bio Techniques 17(5):838-842 (1994).
Porter et al, “A rapid membrane-based viral RNA isolation method for the polymerase chain reaction”, Nucleic Acids Research 19(14):4011 (1991).
Rouse et al, “Induction In Vitro of Primary Cytotoxic T-Lymphocyte Responses with DNA Encoding Herpes Simplex Virus Proteins”, Journal of Virology 68(9):5685-5689 (1994).
Riddell et al, “Class 1 MHC-Restricted Cytotoxic T Lymphocyte Recognition of Cells Infected With Human Cytomegalovirus Does Not Require Endogenous Viral Gene Expression”, The Journal of Immunology 146(8):2795-2804 (1991).
Boczkowski et al, “Dendritic Cells Pulsed wityh RNA are Potent Antigen-Presenting Cells In Vitro and In Vivo”, J. Exp. Med. 284:465-472 (1996).
Rabinovich et al, “Vaccine Technologies: View to the Future”, Science 265:1401-1404 (1994).
Morel et al, “Does preventive vaccination with engineered tumor cells work in cancer-prone transgenic mice?”, Cancer Gene Therapy 5(2):92-100 (1998).
Gomez-Navarro et al, “Gene Therapy for Cancer”, European Journal of Cancer 35(6):867-885 (1999).
Sprent et al, “Lymphocyte Life-Span and Memory”, Science 265:1395-1399 (1994).
Oldstone et al, “How Viruses Escape from Cytotoxic T Lymphocytes: Molecular Parameters and Players”, Virology 234:179-185 (1997) Article No. VY978674.
Pardoll, “Cancer Vaccines”, Nature Medicine Vaccine Supplement 4(5):525-531 (1998).
Cohen et al, “Bumps on the Vaccine Road”, Science 265:1371 (1994).
Gura, “Cancer Models”, Systems for Identifying New Drugs Are Often Faulty, Science 278:1041-1042 (1997).
Crusinberry et al, “Immunotherapy of Renal Cell Cancer”, Seminars in Surgical Oncology 7:221-229 (1991).
Rosenberg et al, “Use of Tumor-Infiltrating Lymphocytes and Intereleukin-2 in the Immunotherapy of Patients With Metastatic Melanoma”, The New England Journal of Medicine 319(25):1676-1680 (1998).
Donis-Keller, H., “Site specific enzymatic cleavage of RNA”, Nucleic Acids Research 7(1):179-192 (1979).
Friedman, H., “Discussion Paper: Protective Immunity in Leukemic Mice Treated with Specific “Immunogenic” RNA”, Annals New York Academy of Sciences 277(00):708-715 (1976).
Greenup et al, “Anti-Tumor Cytotoxicity of Poly(A)-Containing Messenger RNA Isolated From Tumour-Specific Immunogenic RNA”, Br. J. Cancer 38:55-63 (1978).
Aarons et al, “Immune RNA Therapy as an Effective Adjuvant Immunotherapy After Surgery: An Animal Model”, Journal of Surgical Oncology 23:21-26 (1983).
Porgador et al, “Combined Vaccination with Major Histocompatibility Class I and Interleukin 2 Gene-transduced Melanoma Cells Synergizes the Cure of Postsurgical Established Lung Metastases”, Cancer Research 55:4941-4949 (1995).
Rötschke et al, “Exact prediction of a natural T cell epitope”, Eur. J. Immunol. 21:2891-2894 (1991).
van den Bosch et al, “T-Cell-Independent Macrophase Activation in Mice Induced with rRNA fromListeria monocytogenesand Dimethyldioctadecylammonium Bromide”, Infection and Immunity 53(3):611-615 (1986).
Boon et al, “Human Tumor Antigens Recognized by T Lymphocytes”, J. Exp. Med. 183:725-729 (1996).
Rifkind et al, “Delayed Hypertensitivity to Fungal Antigens in Mice. II. Molecular Classes in Immunogenic RNA Extracts that Transfer Delayed Hypersensitivity”, The Journal of Infectious Diseases 133(5):523-532 (1976).
Rifkind et al, “Delayed Hypersensitivity to Fungal Antigens in Mice. III. Characterization of the Active Component in Immunogenic RNA Extracts”, The Journal of Infectious Diseases 133(5):533-537 (1976).
Nair et al, “Cells Treated with TAP-2 Antisense Oligonucleotides Are Potent Antigen-Presenting Cells In Vitro and In Vivo”, The Journal of Immunology 156:1772-1780 (1996).
Inada et al, “Comparison of the Ability of Lactate Dehydrogenase-Elevating Virus and Its Virion RNA To Infect Murine Leukemia Virus-Infected or -Uninfected Cell Lines”, Journal of Virology 67(9):5698-5703 (1993).
Duke et al, “In Vitro Induction of Antibody Formation With Immunogenic RNA”, Annals New York Academy of Sciences 207:145-159 (1973).
Garvey et al, “Characterization of RNA-Antigen Complexes”, Annals New York Academy of Sciences 207:258-278 (1973).
Dodd et al, “Immunogenic RNA in the Immunotherapy of Cancer: The Transfer of Antitumor Cytotoxic Activity and Tuberculin Sensitivity to Human Lymphocytes Using Xenogeneic Ribonucleic Acid”, Annals New York Academy of Sciences 207:454-467 (1973).
Walker et al, “Cationic lipids direct a viral glycoprotein into the class I major histocompatibility complex antigen presentation pathway”, Proc. Natl. Acad. Sci. USA 89:7915-7918 (1992).
Vyas et al, “Specific Immunotherapy Proposed for Hepatitis B Virus Infection”, Develop. biol. Standard. 30:350-356 (1975).
Wu et al, “Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens”, Proc. Natl. Acad. Sci. USA 92:11671-11675 (1995).
Lin et al, “Treatment of Established Tumors with a Novel Vaccine That Enhances Major Histocompatibility Class II Presentation of Tumor Antigen”, Cancer Research 56:21-26 (1996).
Machado et al, “Dialyzable trans
Boczkowski David J.
Gilboa Eli
Nair Smita K.
Duke University
Nixon & Vanderhye P.C.
Wilson Michael C.
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