Methods for treating breast cancer using a mammary cell...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

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C424S185100, C514S002600, C514S021800

Reexamination Certificate

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10193524

ABSTRACT:
Mammastatin has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49 kDa, phosphorylated forms. Mammary cancer cells are inhibited in their growth by the administration of phosphorylated Mammastatin.

REFERENCES:
patent: 4379839 (1983-04-01), Spiegelman
patent: 4753894 (1988-06-01), Frankel et al.
patent: 6451765 (2002-09-01), Ervin, Jr.
patent: WO 89/11491 (1989-11-01), None
patent: WO 89/11492 (1989-11-01), None
Byers, T. (CA Journal, vol. 49, No. 6, Nov./Dec. 1999).
Blat, C. et al., “Inhibitor Diffusible Factor IDF45, A G1 Phase Inhibitor,”Fed. of Europe. Biochem. Soc.,vol. 203, No. 2, pp. 175-180 (Jul. 1986).
Bohmer et al., “Specific Neutralizing Antiserum Against a Polypeptide Growth Inhibitor for Mammary Cells Purified from Bovine Mammary Gland,”Biochem. Biophys. Acta., vol. 846, pp. 145-154 (1985).
Bohmer, F.D. et al., “Identification of a Polypeptide Growth Inhibitor from Bovine Mammary Gland,”J. Biol. Chem., vol. 262, No. 31, pp. 15137-15143 (Nov. 5, 1987).
Bohmer, F.D. et al., “Purification of a Growth Inhibitor for Ehrlich Ascites Mammary Carcinoma Cell from Bovine Mammary Gland,”Exper. Cell Research, vol. 150, pp. 466-476 (1984).
Bronzert, D. et al., “Estrogen Inhibitor of a M, 39,000 Glycoprotein Secreted by Human Breast Cancer Cells,”Cancer Research, vol. 47, pp. 1234-1238 (Mar. 1987).
Budzic, G.P. et al., “A Possible Purification of Mullerian Inhibiting Substance and a Model for its Mechanism of Action”,Devel. Mech.: Normal and Abnormal, Alan R. Liss, Inc., pp. 207-223 (1985).
Burgess, A.W. et al., “The Effect of Colony Stimulating Factor on the Synthesis of Ribonucleic Acid by Mouse Bone Marrow Cells in Vitro,”J. Cell Physiol., vol. 90, pp. 471-484 (1976).
Dalchau et al., “The Purfication of Antigens and other Studies with Monoclonal Antibody Affinity Columns: the Complementary New Dimension of Monoclonal Antibodies,”Monoclonal Antibodies in Clinical Medicine, pp. 519-552 (1982).
Database Dissertation Abstracts Session No. AA19542835 (1995).
Dell'Aquila et al., “A Factor from Plasma-Derived Human Serum that Inhibits the Growth of the Mammary Cell Line MCF-7: Characterization and Purification,”Journal of the National Cancer Institute, vol. 72, pp. 291-298 (1984).
Dell'Aquila et al., “Characterization and Purification of a Factor from Plasma Derived Human Serum which Inhibits the Growth of the Mammary Cell Line MCF-7,”Dissertation Abs. International, vol. 45, No. 6, pp. 1649B-1650B (Dec. 1984).
Dickson, R.B. et al., “Activation of Growth Factor Secretion in Tumorigenic States of Breast Cancer Induced by 17-beta-estradiol or v-Ha-ras Oncogene,”PNAS USA, vol. 84, pp. 837-841 (Feb. 1987).
Ervin et al., “A 40KD Autocrine Growth Inhibitor Produced by Human Mammary Cells,”Proceedings of AACR, vol. 29, No. 230, p. 58 (1998).
Ervin, P.R. et al., “Expression and Testing of Recombinant Mammastatin,”Proceedings of the American Association for Cancer Research, Annual Meeting, vol. 37, p. 399 (Abstract #2722) (Mar. 1996).
Ervin, P.R. et al., “Phosphoralation of the Growth Inhibitor Mammastatin in Normal but not Transformed Human Mammary Cells,”Proceedings of the American Association for Cancer Research, Annual Meeting, vol. 34, p. 150 (Abstract #893) (1993).
Ervin, P.R. et al., “Production of Mammastatin, a Tissue Specific Inhibitor by Normal Human Mammary Cells,”Science, vol. 244, pp. 1585-1587 (Jun. 30, 1989).
Ervin, P.R. et al., “The Active Species of Mammastatin as Expressed in Normal Mammary Cells but not in Mammary Carcinomas,”Proceedings of the American Association for Cancer Research, Annual Meeting, vol. 36, p. 627 (Abstract #3731) (1995).
Ervin, P.R., “Further Characterization and Cloning of the Growth Inhibitor Mammastatin,”PHD Thesis from the University of Michigan, pp. 1-131 (1995).
Freemont et al., “Human Skeletal-Muscel Aldolase: N-Terminal Sequence Analysis of CNBr- and o-lodosobenzoic Acid Cleavage Fragments,”Archives of Biochemsitry and Biophysics, vol. 228, No. 1, pp. 342352 (Jan. 1984).
Garner, I., “Isolation of Total and Poly A+ RNA from Animal Cells,”Methods of Molecular Biology, vol. 28, pp. 4147 (1994).
Goding, J.W., “Monoclonal Antibodies: Principles and Practice,”Academic Press, New York, pp. 5697 (1983).
Goding, J.W., “Monoclonal Antibodies: Principles and Practice,”Academic Press, New York, pp. 250261 (1983).
Holley, R.W. et al., “Purification of Kidney Epithelial Cell Growth Inhibitors,”PNAS USA, vol. 77, No. 10, pp. 59895992 (Oct. 1980).
Hsu, Y. et al., “Growth Control in Cultured 3T3 Fibroblast: Neutralization and Idenification of a Growth-Inhibitory Factor by a Monoclonal Antibody,”PNAS USA, vol. 81, pp. 21072111 (Apr. 1984).
Hsu, Y. et al., “Growth Control in Cultured 3T3 Fibroblasts. V. Purification of an M, 13,000 Polypeptide Responsible for Growth Inhibitory Activity,”J. Cell. Biol, vol. 102, pp. 362-369 (Feb. 1986).
Huff, K.K. et al., “Secretion of an Insulin-like Growth Factor-I-related Protein by Human Breast Cancer Cells,”Cancer Research, vol. 46, pp. 4613-4619 (Sep. 1986).
Hunter, T., “Cell Growth Control Mechanisms,”Nature, vol. 322, pp. 1416 (Jul. 1986).
Jerala, “Simultaneous Synthesis of Degenerate Oligo-nucleotides of Variable Length,”Biotechniques, vol. 13, p. 564 (1992).
Kasukabe, T. et al., “Purification of a Novel Growth Inhibitory Factor for Partially Differentiated Myeloid Leukemic Cells,”J. Biol. Chem., vol. 263, No. 11, pp. 5431-5435 (Apr. 1988).
Kohler et al., “Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity,”Nature, vol. 256, pp. 459-497 (1975).
Kroczek, R.A., “Review: Southern and Northern analysis,”Journal of Chromatography, vol. 618, pp. 133-145 (1993).
Lasken, R.S. et al., “A fidelity assay using “dideoxy” DNA sequencing: A measurement of sequence dependence and frquency of forming 5-bromouracil guanine base mispairs,”Proceedings of the National Academy of Science U.S.A, vol. 82, No. 5, pp. 1301-1305 (1985).
Lippman, M.E. et al., “Autocrine and Paracrine Growth Regulation of Human Breast Cancer,”Breast Cancer Res. Treat., vol. 7, pp. 59-70 (1986).
Marx, J.L., “The Yin and Yang of Cell Growth Control,”Res. News, vol. 30, pp. 1093-1095 (May 1986).
McGrath et al., “Calcium Regulation of Normal Human Mammary Epithelial Cell Growth in Culture,” In Vitro, vol. 20, pp. 652-662 (1984).
McMahon, J.B. et al., “Distribution and Subcellular Localization of a Hepatic Proliferation Inhibitor in Rat Liver,”J. Biol. Chem., vol. 259, No. 3, pp. 1803-1806 (Feb. 1984).
Nakayama, K. et al., “Construction of an ASD+ Expression-Cloning Vector: Stable Maintenance and High Level Expression of Cloned Genes in a Salmonella Vaccine Strain,”Bio/Technology, vol. 6, pp. 693-697 (Jun. 1988).
Nguyen, B. et al., “The Biology of Growth Regulation in Normal and Malignant Breast Epithelium: From Bench to Clinic,”Critical Reviews and Oncology/Hematology, vol. 20, pp. 223-236 (1995).
Nicola, N.A. et al., “The Colony-Stimulating Factors and Myeloid Leukemia,”Cancer Surveys, vol. 4, No. 4, pp. 789-811 (1985).
Pigott et al., “Inhibition of Growth of a Human Mammary Cell Line by Normal Human Serum,” In Vitro, vol. 14, p. 360 (1978).
Sachs, L., “Growth, Differentiation and the Reversal of Malignancy,”Scientific American, pp. 40-47 (Jan. 1986).
Saxon, P.J et al., “Selective Transfer of Individual Human Chromosom

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