Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Reexamination Certificate
2002-01-08
2009-06-09
Huynh, Phuong (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
C424S131100, C424S133100, C424S136100, C424S145100, C530S387100, C530S387200, C530S388100, C530S388230, C530S388240
Reexamination Certificate
active
07544357
ABSTRACT:
The invention provides a method for treating an autoimmune disease in a subject by administering an interferon antagonist and a Flt3 ligand (Flt3L) antagonist. The invention also provides compositions containing one or more interferon antagonists, and one or more Flt3L antagonists, an in vitro assay for determining a subject's risk for developing an autoimmune disease, and kits for use, inter alia, with the assay.
REFERENCES:
patent: 4362155 (1982-12-01), Skurkovich
patent: 4414150 (1983-11-01), Goeddel
patent: 4423147 (1983-12-01), Secher et al.
patent: 4456748 (1984-06-01), Goeddel
patent: 4474754 (1984-10-01), Shimizu et al.
patent: 4534906 (1985-08-01), Johnston
patent: 4605394 (1986-08-01), Skurkovich
patent: 4650674 (1987-03-01), Aggarwal et al.
patent: 4678751 (1987-07-01), Goeddel
patent: 4727138 (1988-02-01), Goeddel et al.
patent: 4762791 (1988-08-01), Goeddel et al.
patent: 4824432 (1989-04-01), Skurkovich et al.
patent: 4828830 (1989-05-01), Wong
patent: 4851219 (1989-07-01), Sherwin
patent: 4902618 (1990-02-01), Berg
patent: 4925793 (1990-05-01), Goeddel et al.
patent: 4944941 (1990-07-01), Ammann
patent: 4973556 (1990-11-01), Bove et al.
patent: 4987071 (1991-01-01), Cech et al.
patent: 5055289 (1991-10-01), Frincke et al.
patent: 5082658 (1992-01-01), Palladino
patent: 5096705 (1992-03-01), Goeddel et al.
patent: 5168053 (1992-12-01), Altman et al.
patent: 5196323 (1993-03-01), Bodo et al.
patent: 5227158 (1993-07-01), Jardieu
patent: 5248499 (1993-09-01), Czarniecki et al.
patent: 5254678 (1993-10-01), Haseloff et al.
patent: 5460811 (1995-10-01), Goeddel et al.
patent: 5554512 (1996-09-01), Lyman et al.
patent: 5582824 (1996-12-01), Goeddel et al.
patent: 5595888 (1997-01-01), Gray et al.
patent: 5827694 (1998-10-01), Capon et al.
patent: 5831023 (1998-11-01), Capon et al.
patent: 5843423 (1998-12-01), Lyman et al.
patent: 5886153 (1999-03-01), Mogensen et al.
patent: 5888511 (1999-03-01), Skurkovich et al.
patent: 5889151 (1999-03-01), Mogensen et al.
patent: 5919452 (1999-07-01), Le et al.
patent: 5919453 (1999-07-01), Benoit et al.
patent: 5959085 (1999-09-01), Garrone et al.
patent: 6136309 (2000-10-01), Novick et al.
patent: 6200780 (2001-03-01), Chen et al.
patent: 6274378 (2001-08-01), Steinman et al.
patent: 6291661 (2001-09-01), Graddis et al.
patent: 6299869 (2001-10-01), Chen et al.
patent: 6299877 (2001-10-01), Chen et al.
patent: 6300475 (2001-10-01), Chen et al.
patent: 6333032 (2001-12-01), Skurkovich et al.
patent: 6458932 (2002-10-01), Novick et al.
patent: 6475983 (2002-11-01), Eid et al.
patent: 6630143 (2003-10-01), Lyman et al.
patent: 6660523 (2003-12-01), Blom et al.
patent: 6673908 (2004-01-01), Stanton, Jr.
patent: 6713609 (2004-03-01), Chuntharapai
patent: 6787634 (2004-09-01), Benoit et al.
patent: 7087726 (2006-08-01), Chuntharapai et al.
patent: 7179465 (2007-02-01), Benoit et al.
patent: 2002/0160974 (2002-10-01), Banchereau et al.
patent: 2003/0018174 (2003-01-01), Kim et al.
patent: 2003/0021764 (2003-01-01), Maroun
patent: 2003/0147889 (2003-08-01), Tovey
patent: 2003/0166228 (2003-09-01), Chuntharapai
patent: 2004/0132139 (2004-07-01), Escary
patent: 2004/0191840 (2004-09-01), Benoit et al.
patent: 2005/0013799 (2005-01-01), Skurkovich et al.
patent: 2005/0013800 (2005-01-01), Skurkovich et al.
patent: 2005/0013813 (2005-01-01), Maroun
patent: 2007/0014724 (2007-01-01), Witte et al.
patent: 0254647 (1988-01-01), None
patent: 0 325 471 (1989-07-01), None
patent: 360257 (1990-03-01), None
patent: 0 627 487 (1997-07-01), None
patent: WO 93/04699 (1993-03-01), None
patent: WO 95/07716 (1995-03-01), None
patent: WO 97/41229 (1997-11-01), None
patent: WO 01/49851 (2001-07-01), None
patent: WO 01/54721 (2001-08-01), None
patent: WO 2004/094473 (2004-11-01), None
patent: WO 2005/059106 (2005-06-01), None
patent: WO 2006/037247 (2006-04-01), None
Ngo et al.,The Protein Folding Problem and Tertiary Structure Prediction, pp. 491-495, 1994.
Mason et al, Molecular Endocrinology 8(3): 325-332, 1994.
Hron et al, J Immunology 173: 2134-2142, 2004.
Van Noort et al, International Review of Cytology 178: 127-205, 1998.
Paquette et al, J Leukocyte Biology 64: 358-367, Sep. 1998.
Santini et al, J Exp Med 191(10): 1777-1788, May 15, 2000.
Blom, et al. (2000) “Generation of interferon aplpha-producing Predendritic Cell (Pre-DC)2 from Human CD34 Hematopoietic Stem Cells”Journal of Experimental Medicine, v. 192 (12): 1785-1795.
Pulendran et al. (2000) “Flt3-Ligand and Granulocyte Colony Stimulating Factor Mobilize Distinct Human Dendritic Cell Subsets in Vivo”Journal of Immunology. 165(1): 566-572.
Gill et al. (2002) “Blood dendritic cells and DC-poietins in systemic lupus erythematosus”Human Immunology, v. 63 (12): 1172-1180.
Blanco, P. et al. “Induction of Dendritic Cell Differentiation by IFN-a in Systemic Lupus Erythematosus”. Nov. 16, 2001, vol. 294, Science, pp. 1540-1543.
Brod, S. et al. “Ingested IFN-α Preserves Residual β Cell Function in Type 1 Diabetes”. Journal of Interferon And Cytokine Research 21:1021-1030 (2001) Mary Ann Liebert, Inc.
Prud'homme, G. et al: “Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors”. The Journal of Gene Medicine, J Gene Med 2000; 2: 222-232.
Shou-Nee, S. et al. “Serum interferon in systemic lupus erythematosus”.British Journal of Dermatology(1987) 117, 155-159.
Suit, B.E. et al: “Detection of anti-interferon antibodies in systemic lupus erythematosus”.Clinical and Experimental Rheumatology1: 133-135, 1983.
Wang, S. et al. “A Unique Combination of Inflammatory Cytokines Enhances Apoptosis of Thyroid Follicular Cells and Transforms Nondestructive to Destructive Thyroiditis in Experimental Autoimmune Thyroiditis”. The Journal of Immunology, 2002, 168: 2470-2474.
Wussow, von P. et al: “Presence of interferon and anti-interferon in patients with systemic lupus erythematosus”. Rheumatol International (1988) 8: 225-230.
Ytterberg, S. et al: “Serum Interferon Levels In Patients With Systemic Lupus Erythematosus”. Arthritis and Rheumatism, vol. 25, No. 4 (Apr. 1982).
Huang, Xiaojian et al. Islet Expression of Interferon-α Precedes Diabetes in both the BB Rat and Streptozotocin-Treated Mice. Immunity 1:469-478 (1994).
Soos, Jeanne M. et al. Oral feeding of interferon T can prevent the acute and chronic relapsing forms of experimental allergic encephalomyelitis. Journal of Neuroimmunology 75:43-50 (1997).
PCT Notification of Transmittal of International Search Report or The Declaration for PCT/US02/00343, dated Dec. 4, 2002.
Banchereau, J.; Brier, F.; Caux, C.; Davoust, J.; Lebecque, S.; Liu, Y.J. “Immunology of Dendritic Cells”Annual Review of Immunologyvol. 18, pp. 767-811 (2000).
Blazar, B.R.; McKenna, H.J.; Panoskaltsis-Mortari, A.; Taylor, P.A.; “Flt3 Ligand (FL) Treatment of Murine Donors Does Not Modify Graft-Versus-Host Disease (GVHD) But FL Treatment of Recipients Post-Bone Marrow Transplantation Accelerates GVHD Lethality”Biology of Blood and Marrow Transplantationvol. 7, Issue 4, pp. 197-207 (2001).
Chakrabarti, D.; Hultgren, B.; Stewart, T.A. “IFN-α Induces Autoimmune T Cells Through the Induction of Intracellular Adhesion Molecule-1 and B7.2”Journal of Immunologyvol. 157, pp. 522-528 (1996).
Chuntharapai, A.; Lai, J.; Huang, X.; Gibbs, V.; Kim, K.J.; Presta, L.G.; Stewart, T.A. “Characterization and Humanization of Monoclonal Antibody That Neutralizes Human Leukocyte Interferon: a Candidate Therapeutic for IDDM and SLE”Cytokinevol. 15, No. 5.
Panem, Sandra, et al., “Antibodies to α-Interferon in a Patient with Systemic Lupus Erythematosus”, J. Immunology, 1982, p. 1-3, vol. 129, No. 1.
Alkan and Braun (1986)Ciba Found. Symp. 119; 264-278, entitled “Epitope Mapping of Human Recombinant Interferon alpha Molecules by Monoclonal Antibodies.”
Baechler et al. (2003)Proc. Nat'l. Acad. Sci
Banchereau Jacques F.
Blanco Patrick
Palucka Anna Karolina
Baylor Research Institute
Brinks Hofer Gilson & Lione
Huynh Phuong
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