Methods for treating asthma using optically pure (-)-zileuton

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3138

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active

056293372

ABSTRACT:
Methods are disclosed utilizing optically pure (-)-zileuton for the treatment of asthma in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of zileuton.

REFERENCES:
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Siris et al. "Effect of Zileuton (A-64077) on the 5-Lipoxygenase activity of human whole blood ex vivo" Agents and Actions, 34, 117-120 (1991).
Weinblatt et al. "Zileuton, A 5-Lipoxygenase Inhibitor in Rheumatoid Arthritis" J. Rheum. 19, 1537-1541 (1992).
Laursen et al. "Selective 5-lipoxygenase inhibition in ulcerative colitis" Lancet 335, 683-685 (1990).
Israel et al. "The Effects of a 5-Lipoxygenase Inhibitor on Asthma Induced By Cold, Dry Air" N. Eng. J. Med. 323, 1740-1744 (1990).
Collawn et al. "Phase II Study of the Safety and Efficacy of a 5-Lipoxygenase Inhibitor in Patients with Ulcerative Colitis" Amn. J. Gastro. 87, 342-346 (1992).
Knapp "Reduced Allergen-Induced Nasal Congestion and Leukotriene Synthesis With An Orally Active 5-Lipoxygenase Inhibitor" N. Eng. J. Med. 323, 1745-1748 (1990).

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