Methods for treating arthritis by administering an apoptosis reg

Details Methods for treating arthritis by administering an apoptosis reg Methods for treating arthritis by administering an apoptosis reg

1996-08-30

1999-12-21

Crouch, Deborah

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 435455, A61K 4800, C12N 500, C12N 1500

Patent

active

060049421

ABSTRACT:
The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.

REFERENCES:
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Roessler et al., "Adenoviral-mediated Gene Transfer to Rabbit Synovium In Vivo", Journal of Clinical Investigation, Aug., 1993, vol. 92, pp. 1085-1092.
Firestein et al., "Apoptosis in Rheumatoid Arthritis Synovium", Arthritis and Rheumatism, Abstracts of Scientific Presentations, Sep. 1994, vol. 37, No. 9 (Supplement), p. s311, Abstract 899.
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Evans and Robbins, 1996, "Pathways to gene therapy in rheumatoid arthritis," Curr. Opin. Rheumatol. 8(3):230-4.
Makarov et al., 1996, "Suppression of experimenmtal arthritis by gene transfer of interleukin 1 receptor antagonists cDNA," Proc. Nat'l. Acad. Sci. 93(1):402-6.
Chernajovsky et al., 1995, "Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tomor necrosis factor recreptor," Gene Ther. 2(10):731-5.
Hanania et al., 1995, "Recent Advances in the Application of Gene Therapy to Human Disease," Am. J. Med. 99(5):537-552.
Evans and Robbins, 1995, "Progress toward the Treatment of Arthritis by Gene Therapy," Ann. Med. 27(5):543-546.
Zang et al., 1997, "Amelioration of Collagen-induced Arthritis by CD95 (Apo-1/Fas)-ligand Gene Transfer," J. Clin. Invest. 100(8):1951-1957.
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