Methods for treating and diagnosing cancer with WNT...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S185100, C424S192100

Reexamination Certificate

active

07618936

ABSTRACT:
This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.

REFERENCES:
patent: 6844422 (2005-01-01), Niehrs et al.
patent: 2002/0192216 (2002-12-01), Lamb et al.
patent: 2003/0040051 (2003-02-01), Bhanot et al.
patent: 2004/0126359 (2004-07-01), Lamb et al.
patent: 2004/0171153 (2004-09-01), Andrews et al.
patent: 2005/0049195 (2005-03-01), Zou
patent: 1489168 (2004-12-01), None
patent: 9913350.6 (1999-06-01), None
patent: WO 97/39357 (1997-10-01), None
patent: WO 99/22000 (1999-05-01), None
patent: WO 00/74706 (2000-12-01), None
patent: WO 02/077204 (2002-10-01), None
patent: WO 02/080952 (2002-10-01), None
patent: WO 02/090992 (2002-11-01), None
patent: WO 2004/058949 (2003-12-01), None
patent: WO 2004/026908 (2004-04-01), None
patent: WO 2004/058949 (2004-07-01), None
Bowie et al (Science, 1990, 247:1306-1310).
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4).
Dermer (Bio/Technology, 1994, 12:320).
Taniguchi et al, Oncogene 2005, 24:7946-7952.
Lin et al (Human Gene Therapy, 2007, 18:379 abstract only).
He, Biao et al.; “A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells”; 2004,Neoplasia, vol. 6, No. 1, pp. 7-14.
Hsieh, Jen-Chih et al.; “A new secreted protein that binds to Wnt proteins and inhibits their activites”; 1999,Nature, vol. 398, pp. 431-436.
Wissmann, Christoph et al.; “WIFI, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer”; 2003,J. Pathol., vol. 201, pp. 204-212.
He Biao et al, “Blockade of Wnt-1 signaling induces adoptosis in human colorectal cancer cells containing downstream mutations”, Oncogene, vol. 24, No. 18, Apr. 18, 2005, pp. 3054-3058, XP002470043, ISSN:0950-9232.
Laird PW, “The Power and The Promise of DNA Methylation Markers”, Nature Reviews. Cancer, Nature Publishing Group, London, GB, Vol. 3, No. 4, Apr. 2003, pp. 253-266, XP009044309, ISSN: 1474-175X.
Mazieres J et al, “Wnt signaling in ling cancer”, Cancer Letters, New York, NY, US, vol. 222, No. 1, May 10, 2005, pp. 1-10, XP004856230, ISSN: 0304-3835.
Cebrat, Malgorzata et al.; “Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells”; 2004, Cancer Letters, vol. 206, pp. 107-113.
Chen, Shaoqiong et al.; “Wnt-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor-mediated Transcription”; 2001,The Journal of Cell Biology, vol. 152, pp. 87-96.
Herman, James G. et al.; “Gene Silencing in Cancer in Association with Promoter Hypermethylation”; 2003,The New England Journal of Medicine, vol. 349, pp. 2042-2054.
Iiyas, Mohammad; “Wnt signalling and the mechanistic basis of tumour development”; 2005,Journal of Pathology, vol. 205, pp. 130-144.
Mazieres, Julien et al.; “Wnt Inhibitory Factor-1 is Silenced by Promoter Hypermethylation in Human Lung Cancer”; 2004,Cancer Research, vol. 64, pp. 4717-4720.
Ohigashi, T. et al.; “Inhibition of Wnt Signaling Downregulates Akt Activity and Induces Chemosensitivity in PTEN-Mutated Prostate Cancer Cells”; 2005,The Prostate, vol. 62, pp. 61-68.
Reguart, Noemi et al.; “Cloning and characterization of the promoter of human Wnt inhibitory factor-1”; 2004,Biochemical and Biophysical Research Communications, vol. 323, pp. 229-234.
Taniguchi, Hiroaki et al.; “Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers”; 2005,Oncogene, pp. 1-7.
You, Zongbing et al.; “Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis”; 2002,The Journal of Cell Biology, vol. 157, No. 3, pp. 429-440.
Zochbauer-Muller, Sabine et al.; “Aberrant Promoter Methylation of Multiple Genes in Non-Small Cell Lung Cancers”; 2001,Cancer Research, vol. 61, pp. 249-255.

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