Methods for treating an artery or vein in a human subject

Details Methods for treating an artery or vein in a human subject Methods for treating an artery or vein in a human subject

2006-06-20

2006-06-20

Gitomer, Ralph (Department: 1655)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

Reexamination Certificate

active

07063838

ABSTRACT:
The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes preventively dilating a section of conduit to minimize the risk of obstruction formation.

REFERENCES:
patent: 4636195 (1987-01-01), Wolinsky et al.
patent: 4803294 (1989-02-01), Mueller et al.
patent: 4968614 (1990-11-01), Takiguchi et al.
patent: 4985361 (1991-01-01), Takiguchi et al.
patent: 5041091 (1991-08-01), Herring
patent: 5116615 (1992-05-01), Gokeen et al.
patent: 5162205 (1992-11-01), Takiguichi et al.
patent: 5212068 (1993-05-01), Takiguchi et al.
patent: 5397694 (1995-03-01), Atkinson et al.
patent: 5489261 (1996-02-01), Franzblau et al.
patent: 5710035 (1998-01-01), Greene et al.
patent: 5834449 (1998-11-01), Thompson et al.
patent: 5922322 (1999-07-01), Bini
patent: 5944710 (1999-08-01), Dev et al.
patent: 6074659 (2000-06-01), Kunz et al.
patent: 6074664 (2000-06-01), Roreger et al.
patent: 6143744 (2000-11-01), Broka et al.
patent: 6347247 (2002-02-01), Dev et al.
patent: WO 96/18725 (1996-06-01), None
Singleton, P. et al., Dictionary of Microbiology and Molecular Biology, 1991. John Wiley and Sons, p. 320.
Anidjar et al. Annals of Vascular Surgery, 1994. vol. 8, pp. 1128-136.
Ooyama et al. The Molecular Biology and Pathology of Elastic Tissues. 1993. Wiley Chichester, pp. 307-320.
Strindberg et al. Journal of Investigative Surgery, 1998. vol. 11, pp. 185-198.
L. Maillard et al.,Gene Therapy, 5:1023-1030 (1998).
C. Carsten et al.,Journal of Vascular Surgery, 33(6):1255-1262 (2001).
M. Matsushita et al.,Eur. Surg. Res., 31:305-313 (1999).
M. Hasegawa,Biorheology, 20:531-545 (1983).
D. Dobrin et al.,Surgery, 104(3):568-571 (1988).
S. Anidjar et al.,J. Vasc. Surg., 16(2):139-147 (1992).
S. Anidjar et al.,Circulation, 82(3):973-981 (1990).
N. Origuchi et al.,International Angiology, 17(2):113-119 (1998).
N. Fujiwara et al.,Am. J. Neuroradiol., 22:698-703 (2001).
J. White,Journal of Vascular Surgery, 153-154 (1994).
J.V. White et al.,Ann. NY Acad. Sci., 800:97-120 (Nov. 18, 1996).
Altes et al.,AJR, 174:349-354 (Feb. 2000).
L. Miskolczi et al.,Neurosurgery, 43(3):595-600 (1998).
L. Erlendsson et al.,Comparative Biochemistry and Physiology, Part B, 120:549-557 (1998).
S. Anidjar et al.,Ann. Vasc. Surg., 8(2):127-136 (1994).
P. Dobrin et al.,Arch. Surg., 119:405-409 (1984).
R. Geary et al.,J. Vasc. Surg., 27(1):96-108 (1998).
G. Hammond et al.,J. Surgical Research, 12:313-317 (1972).
J. Kabemba et al.,Surgery, 73(3):438-443 (1973).
L. Miskolezi et al.,Neurosurgery, 41(1):220-229 (1997).
Y. Muto et al.,Japan J. Surg., 16(3):225-230 (1986).
T. Ooyama et al.,The Molecular Biology and Pathology of Elastic Tissues, Wiley, Chichester (Ciba Foundation Symposium 192), pp. 307-320 (1995).
M. Osman et al.,J. Lab Clin. Med., 105(2):254-258 (1985).
R. Senior et al.J. Biol. Chem.266(12):7870-7875 (1991).
J. White et al.,J. Vasc. Surg., 17(2):371-381 (1993).
T. Abbruzzese et al.,Surgery, 124:328-335 (1998).
M. Arakawa et al.,Japanese Journal of Clinical and Experimental Medicine, 62(3):1-15 (1985).
H. Cloft et al.;Radiology, 213:223-238 (1999).
G. Strindberg et al.,Journal of Investigative Surgery, 11(3):185-197 (1998).
A. Lafont et al.,Seminars in Interventional Cardiology, 2(3):177-182 (1997).
J. Curci et al.Journal of Vascular Surgey, 385 (Feb. 1999).
G. Moore et al.,Journal of Vascular Surgery, 29:522-532 (1999).
T. Kitoh et al.,American Journal of Physiology, 265(1 Pt 2):H273-80 (1993).
D. Petrinec et al.Journal of Vascular Surgery, 23(2):336-46 (1996).
Johnson MS et al., The Porcine Hemodialysis Access Model, Journal of Vascular and Interventional Radiology 2001;12:969-977.
Strauss BH et al., Extracellular Matrix Remodeling After Balloon Angioplasty Injury in a Rabbit Model of Restenosis, Circulation Research 1994;75:650-658.
Wilensky RL et al., Vascular Injury, Repair, and Restenosis After Percutaneous Transluminal Angioplasty in the Atherosclerotic Rabbit, Circulation 1995;92:2995-3005.
Dobrin PB & Mrkvicka R, Cardiovasc. Surg. 2(4): 484-488 (1994).
Trubel W et al., Eur. J. Vasc. Endovasc. Surg. 10: 415-423 (1995).

Affiliated with

Also associated with

Rating

Methods for treating an artery or vein in a human subject does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for treating an artery or vein in a human subject, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treating an artery or vein in a human subject will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3669835