Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-08-01
1996-09-17
Burn, Brian
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424570, 514811, 514812, 514813, A61K 3817
Patent
active
055568378
ABSTRACT:
The present invention is broadly directed to treatment of an addictive disease or disorder. In particular, the invention relates to inhibiting or reversing the biochemical and neurophysiological changes that correlate with behavioral changes of addictive diseases or disorders. The method of the invention comprises administering to a subject suspected of suffering from an addictive disease or disorder an amount of brain-derived factor (BDNF) or neurotrophin-4 (NT-4), or both, effective to reverse behavioral changes that are associated with the addictive disease or disorder. In a specific Example, administration of BDNF or NT-4 inhibits or reverses increased expression of tyrosine hydroxylase and glial ibrillary acidic protein in the ventral tegmental area of the brain, and inhibits or reverses increased levels of cyclic-AMP-dependent protein kinase activity in the nucleus accumbens.
REFERENCES:
patent: 5169764 (1992-12-01), Shooter et al.
patent: 5180820 (1993-01-01), Barde et al.
patent: 5229500 (1993-07-01), Barde et al.
Berhow et al., 1994, Soc. Neurosci. Abst. 20:454.18.
Fandl et al., 1994, J. Biol. Chem. 269:755-759.
Hyman et al., 1994, J. Neurosci. 14:335-347.
Lindsay et al., 1994, TINS 17:182-90.
Beitner-Johnson et al., 1993, Soc. Neurosci. Abst. 19:663.
Ip et al., 1993, J. Neuroscience 13:3394-3405.
Ip et al., 1993, Neuron 10:89-102.
Nestler et al., 1993, Neuron 11:995-1006.
Lindsay et al., 1993, Experimental Neurology 124:103-118.
Wong et al., 1993, European J. Neuroscience 5:466-474.
Ip et al., 1992, Proc. Natl. Acad. Sci. USA 89:3060-3064.
Langer, 1990, Science 249:1527-1533.
Lindsay and Rohrer, 1985, Develop. Biol. 112:30-48.
Barde et al., 1982, EMBO J. 1:549-553.
Barde et al., 1980, Proc. Natl. Acad. U.S.A. 77:1199-1203.
Beitner-Johnson Dana
Berhow Melissa T.
Lindsay Ronald M.
Nestler Eric J.
Russell David S.
Burn Brian
Regeneron Pharmaceuticals Inc.
Yale University
LandOfFree
Methods for treating addictive disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for treating addictive disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treating addictive disorders will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-413092