Methods for treating a disease in which Rho kinase is involved

Details Methods for treating a disease in which Rho kinase is involved Methods for treating a disease in which Rho kinase is involved

2009-06-19

2010-12-21

Chung, Susannah (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S346100, C548S356100

Reexamination Certificate

active

07855222

ABSTRACT:
A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof:wherein the ring X is a benzene ring or a pyridine ring; R1and R2are hydrogen or alkyl or together form a cycloalkene ring; R3is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5is a halogen atom or a hydrogen atom.

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