Methods for the treatment of retroviral infections

Details Methods for the treatment of retroviral infections Methods for the treatment of retroviral infections

1990-12-31

1992-08-25

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 4241951, 530370, A61K 3702

Patent

active

051419238

ABSTRACT:
The present invention provides novel methods for the treatment of retroviral infection, particularly HIV disease. According to the present invention, human HIV infected hosts were selected who had been on a stable dose of an anti-retroviral agent, such as zidovudine, for up to two years prior to administration of the ribosomal inhibiting protein trichosanthin, and who had failed anti-retroviral therapy, as manifest by decrease in CD4+ cells on at least two serial measurements, or loss of over 50 CD4+ cells/mm.sup.3 /year. These patients remained on the same dose of anti-retroviral agent (AZT or ddI) and received trichosanthin, 1.2 mg weekly, then monthly. A significant number of patients demonstrated improved CD4+ cell counts following administration of trichosanthin as compared to CD4+ cell counts prior to adminstration of the drug.

REFERENCES:
patent: 4795739 (1989-01-01), Lifson et al.
patent: 4869903 (1989-09-01), Lifson et al.
patent: 4937074 (1990-06-01), Venkateswaran et al.

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